PDB entry 6fj3

View 6fj3 on RCSB PDB site
Description: high resolution crystal structure of parathyroid hormone 1 receptor in complex with a peptide agonist.
Deposited on 2018-01-19, released 2018-11-21
The last revision was dated 2020-07-29, with a file datestamp of 2020-06-29.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: N/A
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Parathyroid hormone/parathyroid hormone-related peptide receptor,Parathyroid hormone/parathyroid hormone-related peptide receptor,GlgA glycogen synthase,Parathyroid hormone/parathyroid hormone-related peptide receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: PTH1R, PTHR, PTHR1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q03431 (Start-38)
    • Uniprot Q03431 (39-322)
      • engineered mutation (125)
      • engineered mutation (174)
      • engineered mutation (234)
      • engineered mutation (246)
      • engineered mutation (268)
      • engineered mutation (293)
    • Uniprot Q9V2J8 (323-518)
    • Uniprot Q03431 (519-601)
      • engineered mutation (528)
      • engineered mutation (547)
      • engineered mutation (561)
      • engineered mutation (579)
  • Chain 'B':
    Compound: parathyroid hormone
    Species: Equus caballus [TaxId:9796]
    Gene: PTH
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q27IM2 (0-33)
      • conflict (0)
      • conflict (2)
      • engineered mutation (9)
      • conflict (10)
      • engineered mutation (11)
      • engineered mutation (13)
      • conflict (17)
      • engineered mutation (33)
  • Heterogens: MAN, OLA, ACY, PG4, CL, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6fj3A (A:)
gpalvdaddvmtkeeqifllhraqaqcekrlkevlqrpagrpclpewdhilcwplgapge
vvavpcpdyiydfnhkghayrrcdrngswelvpghnrtwanysecvkfltnetrerevfd
rlgmictvgysvslasltvavlilayfrrlhctrnyihmhlflsfmlravsifvmdavly
sgatldeaerlteeelraiaqappppataaagyagcrvavtfflyflatnyywiavegly
lhslifkaffsekkylwgftvfgwglpaifvavwvsvratlantgcwdlssgnnkwiiqv
pilasivlnfilfinivrvlatkgidcsfwnesyltgsrderkksllskfgmdegvtfmf
igrfdrgqkgvdvllkaieilsskkefqemrfiiigkgdpelegwarsleekhgnvkvit
emlsrefvrelygsvdfviipsyfepfglvaleamclgaipiasavgglrdiitnetgil
vkagdpgelanailkalelsrsdlskfrenckkramsfsdtrqqyrklakstlvlmplfg
vhyivfmltpytevsgtlwqvrmhyemlfnsfqgffvaiaycfcngevqaeikkswsrwt
la

    Sequence, based on observed residues (ATOM records):
    >6fj3A (A:)
vmtkeeqifllhraqaqcekrlkevlqrpagrpclpewdhilcwplgapgevvavpcpdy
iydfnhkghayrrcdrngswelvpghnrtwanysecvkfltnetrerevfdrlgmictvg
ysvslasltvavlilayfrrlhctrnyihmhlflsfmlravsifvmdavlysyagcrvav
tfflyflatnyywiaveglylhslifkaffsekkylwgftvfgwglpaifvavwvsvrat
lantgcwdlssgnnkwiiqvpilasivlnfilfinivrvlatkgidcsfwnesyltgsrd
erkksllskfgmdegvtfmfigrfdrgqkgvdvllkaieilsskkefqemrfiiigkgdp
elegwarsleekhgnvkvitemlsrefvrelygsvdfviipsyfepfglvaleamclgai
piasavgglrdiitnetgilvkagdpgelanailkalelsrsdlskfrenckkramsfsd
trqqyrklakstlvlmplfgvhyivfmltpytevsgtlwqvrmhyemlfnsfqgffvaia
ycfcngevqaeikkswsrwtla

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records:
    >6fj3B (B:)
xvaeiqlmhqrakwlnslervewlrkklqdvhny