PDB entry 6fiq

View 6fiq on RCSB PDB site
Description: DDR1, 1-(1H-indazole-5-carbonyl)-5'-methoxy-1'-[2-oxo-2-[(2S)-2-(trifluoromethyl)pyrrolidin-1-yl]ethyl]spiro[piperidine-4,3'-pyrrolo[3,2-b]pyridine]-2'-one, 1.790A, P212121, Rfree=23.8%
Class: transferase
Keywords: rtk, receptor tyrosine kinase, collagen, discoidin domain;, transferase
Deposited on 2018-01-19, released 2018-11-28
The last revision prior to the SCOPe 2.07 freeze date was dated 2018-11-28, with a file datestamp of 2018-11-23.
Experiment type: XRAY
Resolution: 1.79 Å
R-factor: N/A
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: epithelial discoidin domain-containing receptor 1
    Species: Homo sapiens [TaxId:9606]
    Gene: DDR1, CAK, EDDR1, NEP, NTRK4, PTK3A, RTK6, TRKE
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6fiqa_
  • Heterogens: DJW, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >6fiqA (A:)
    pgavgdgpprvdfprsrlrfkeklgegqfgevhlcevdspqdlvsldfplnvrkghpllv
    avkilrpdatknarndflkevkimsrlkdpniirllgvcvqddplcmitdymengdlnqf
    lsahqledkaaegapgdptisypmllhvaaqiasgmrylatlnfvhrdlatrnclvgenf
    tikiadfgmsrnlyagdyyrvqgravlpirwmawecilmgkfttasdvwafgvtlwevlm
    lcraqpfgqltdeqvienageffrdqgrqvylsrppacpqglyelmlrcwsreseqrppf
    sqlhrflaedalntvhhhhhh
    

    Sequence, based on observed residues (ATOM records): (download)
    >6fiqA (A:)
    prvdfprsrlrfkeklgegqfgevhlcevdspqdpllvavkilrpdatknarndflkevk
    imsrlkdpniirllgvcvqddplcmitdymengdlnqflsahqledkaaegapgdptisy
    pmllhvaaqiasgmrylatlnfvhrdlatrnclvgenftikiadfgmsrnlyagdyyrvq
    gravlpirwmawecilmgkfttasdvwafgvtlwevlmlcraqpfgqltdeqvienagef
    frdqgrqvylsrppacpqglyelmlrcwsreseqrppfsqlhrflaedalntv