PDB entry 6fil

View 6fil on RCSB PDB site
Description: DDR1, 2-[8-(1H-indazole-5-carbonyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl]-N-methylacetamide, 1.730A, P212121, Rfree=24.5%
Class: transferase
Keywords: rtk, receptor tyrosine kinase, collagen, discoidin domain;, transferase
Deposited on 2018-01-19, released 2018-11-28
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-03-27, with a file datestamp of 2019-03-22.
Experiment type: XRAY
Resolution: 1.73 Å
R-factor: N/A
AEROSPACI score: 0.4 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: epithelial discoidin domain-containing receptor 1
    Species: Homo sapiens [TaxId:9606]
    Gene: DDR1, CAK, EDDR1, NEP, NTRK4, PTK3A, RTK6, TRKE
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6fila_
  • Heterogens: D6W, IOD, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6filA (A:)
pgavgdgpprvdfprsrlrfkeklgegqfgevhlcevdspqdlvsldfplnvrkghpllv
avkilrpdatknarndflkevkimsrlkdpniirllgvcvqddplcmitdymengdlnqf
lsahqledkaaegapgdptisypmllhvaaqiasgmrylatlnfvhrdlatrnclvgenf
tikiadfgmsrnlyagdyyrvqgravlpirwmawecilmgkfttasdvwafgvtlwevlm
lcraqpfgqltdeqvienageffrdqgrqvylsrppacpqglyelmlrcwsreseqrppf
sqlhrflaedalntvhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6filA (A:)
dfprsrlrfkeklgegqfgevhlcevdsppllvavkilrpdatknarndflkevkimsrl
kdpniirllgvcvqddplcmitdymengdlnqflsahqledkaaegapgdptisypmllh
vaaqiasgmrylatlnfvhrdlatrnclvgenftikiadfgmsrnlyagdyyrvqgravl
pirwmawecilmgkfttasdvwafgvtlwevlmlcraqpfgqltdeqvienageffrdqg
rqvylsrppacpqglyelmlrcwsreseqrppfsqlhrflaedalnt