PDB entry 6ffm
View 6ffm on RCSB PDB site
Description: Crystal Structure of Human KEAP1 BTB Domain in Complex with isoxazoline-based inhibitor
Class: signaling protein
Keywords: 3-bromo-4 5-dihydroisoxazole, BTB domain, antioxidant response, Signaling protein
Deposited on
2018-01-08, released
2018-11-14
The last revision prior to the SCOPe 2.08 freeze date was dated
2018-11-14, with a file datestamp of
2018-11-09.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: N/A
AEROSPACI score: 0.27
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Kelch-like ECH-associated protein 1
Species: Homo sapiens [TaxId:9606]
Gene: KEAP1, INRF2, KIAA0132, KLHL19
Database cross-references and differences (RAF-indexed):
- Uniprot Q14145 (Start-135)
- engineered mutation (127)
Domains in SCOPe 2.08: d6ffma_ - Heterogens: D8N, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>6ffmA (A:)
ghmgnrtfsytledhtkqafgimnelrlsqqlcdvtlqvkyqdapaaqfmahkvvlasss
pvfkamftnglreqgmevvsiegihpkvmerliefaytasismgekcvlhvmngavmyqi
dsvvracadflvqqld
Sequence, based on observed residues (ATOM records): (download)
>6ffmA (A:)
rtfsytledhtkqafgimnelrlsqqlcdvtlqvkyqdapaaqfmahkvvlassspvfka
mftnglreqgmevvsiegihpkvmerliefaytasismgekcvlhvmngavmyqidsvvr
acadflvqqld