PDB entry 6ffb

View 6ffb on RCSB PDB site
Description: 17beta-hydroxysteroid dehydrogenase 14 variant s205 - mutant q148a - in complex with a nonsteroidal inhibitor
Deposited on 2018-01-05, released 2019-01-30
The last revision was dated 2020-07-29, with a file datestamp of 2020-06-29.
Experiment type: XRAY
Resolution: 1.65 Å
R-factor: N/A
AEROSPACI score: 0.5 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 17-beta-hydroxysteroid dehydrogenase 14
    Species: Homo sapiens [TaxId:9606]
    Gene: HSD17B14, DHRS10, SDR3, SDR47C1, UNQ502/PRO474
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9BPX1
      • engineered mutation (149)
      • variant (206)
  • Heterogens: NAD, NA, BGC, F45, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6ffbA (A:)
ghmatgtryagkvvvvtgggrgigagivrafvnsgarvvicdkdesggraleqelpgavf
ilcdvtqeddvktlvsetirrfgrldcvvnnaghhpppqrpeetsaqgfrqllelnllgt
ytltklalpylrksqgnvinisslvgaigaaqavpyvatkgavtamtkalaldespygvr
vncispgniwtplweelaalmpdprasiregmlaqplgrmgqpaevgaaavflaseanfc
tgiellvtggaelgygckasrstpvdapdipsgs

    Sequence, based on observed residues (ATOM records):
    >6ffbA (A:)
gtryagkvvvvtgggrgigagivrafvnsgarvvicdkdesggraleqelpgavfilcdv
tqeddvktlvsetirrfgrldcvvnnaghhpppqrpeetsaqgfrqllelnllgtytltk
lalpylrksqgnvinisslvgaigaaqavpyvatkgavtamtkalaldespygvrvncis
pgniwtplweelaalmpdprasiregmlaqplgrmgqpaevgaaavflaseanfctgiel
lvtggaelgypdi