PDB entry 6ffa

View 6ffa on RCSB PDB site
Description: FMDV Leader protease bound to substrate ISG15
Class: hydrolase
Keywords: Leader protease, deISGylase, deubiquitinase, HYDROLASE
Deposited on 2018-01-05, released 2018-02-21
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-03-14, with a file datestamp of 2018-03-09.
Experiment type: XRAY
Resolution: 1.5 Å
R-factor: N/A
AEROSPACI score: 0.48 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Lbpro
    Species: Foot-and-mouth disease virus [TaxId:12110]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03305 (0-End)
      • conflict (97)
    Domains in SCOPe 2.08: d6ffaa_
  • Chain 'B':
    Compound: Ubiquitin-like protein ISG15
    Species: Homo sapiens [TaxId:9606]
    Gene: ISG15, G1P2, UCRP
    Database cross-references and differences (RAF-indexed):
    • Uniprot P05161 (1-77)
      • initiating methionine (0)
      • engineered mutation (77)
    Domains in SCOPe 2.08: d6ffab_
  • Heterogens: GOL, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6ffaA (A:)
meltlyngekktfysrpnnhdncwlnailqlfryveepffdwvysspenltleaikqled
ltglelheggppalviwnikhllhtgigtasrpsevcvvdgtdmcladfhagiflkgqeh
avfacvtsngwyaiddedfypwtpdpsdvlvfvpydqeplngewkak

    Sequence, based on observed residues (ATOM records): (download) 
    >6ffaA (A:)
meltlyngekktfysrpnnhdncwlnailqlfryveepffdwvysspenltleaikqled
ltglelheggppalviwnikhllhtgigtasrpsevcvvdgtdmcladfhagiflkgqeh
avfacvtsngwyaiddedfypwtpdpsdvlvfvpyd

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6ffaB (B:)
mdeplsilvrnnkgrsstyevrltqtvahlkqqvsglegvqddlfwltfegkpledqlpl
geyglkplstvfmnlrlx