SCOPe 2.08: Structural Classification of Proteins

PDB entry 6fer

View 6fer on RCSB PDB site
Description: Crystal Structure of human DDR2 kinase in complex with 2-[4,5-difluoro-2-oxo-1'-(1H-pyrazolo[3,4-b]pyridine-5-carbonyl)spiro[indole-3,4'-piperidine]-1-yl]-N-(2,2,2-trifluoroethyl)acetamide
Class: transferase
Keywords: rtk, receptor tyrosine kinase, collagen, discoidin domain;, transferase
Deposited on 2018-01-03, released 2018-11-28
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-03-27, with a file datestamp of 2019-03-22.
Experiment type: XRAY
Resolution: 2.87 Å
R-factor: N/A
AEROSPACI score: 0.16 (click here for full SPACI score report)

Chains and heterogens:

Chain 'A':
Compound: Discoidin domain-containing receptor 2
Species: Homo sapiens [TaxId:9606]
Gene: DDR2, NTRKR3, TKT, TYRO10
Database cross-references and differences (RAF-indexed):
- Uniprot Q16832 (0-End)
Domains in SCOPe 2.08: d6fera_
Chain 'B':
Compound: Discoidin domain-containing receptor 2
Species: Homo sapiens [TaxId:9606]
Gene: DDR2, NTRKR3, TKT, TYRO10
Database cross-references and differences (RAF-indexed):
- Uniprot Q16832 (0-End)
Domains in SCOPe 2.08: d6ferb_
Chain 'C':
Compound: Discoidin domain-containing receptor 2
Species: Homo sapiens [TaxId:9606]
Gene: DDR2, NTRKR3, TKT, TYRO10
Database cross-references and differences (RAF-indexed):
- Uniprot Q16832 (0-End)
Domains in SCOPe 2.08: d6ferc_
Chain 'D':
Compound: Discoidin domain-containing receptor 2
Species: Homo sapiens [TaxId:9606]
Gene: DDR2, NTRKR3, TKT, TYRO10
Database cross-references and differences (RAF-indexed):
- Uniprot Q16832 (0-End)
Domains in SCOPe 2.08: d6ferd_
Chain 'E':
Compound: Discoidin domain-containing receptor 2
Species: Homo sapiens [TaxId:9606]
Gene: DDR2, NTRKR3, TKT, TYRO10
Database cross-references and differences (RAF-indexed):
- Uniprot Q16832 (0-End)
Domains in SCOPe 2.08: d6fere_
Chain 'F':
Compound: Discoidin domain-containing receptor 2
Species: Homo sapiens [TaxId:9606]
Gene: DDR2, NTRKR3, TKT, TYRO10
Database cross-references and differences (RAF-indexed):
- Uniprot Q16832 (0-End)
Domains in SCOPe 2.08: d6ferf_
Chain 'G':
Compound: Discoidin domain-containing receptor 2
Species: Homo sapiens [TaxId:9606]
Gene: DDR2, NTRKR3, TKT, TYRO10
Database cross-references and differences (RAF-indexed):
- Uniprot Q16832 (0-End)
Domains in SCOPe 2.08: d6ferg_
Chain 'H':
Compound: Discoidin domain-containing receptor 2
Species: Homo sapiens [TaxId:9606]
Gene: DDR2, NTRKR3, TKT, TYRO10
Database cross-references and differences (RAF-indexed):
- Uniprot Q16832 (0-End)
Domains in SCOPe 2.08: d6ferh_
Chain 'I':
Compound: Discoidin domain-containing receptor 2
Species: Homo sapiens [TaxId:9606]
Gene: DDR2, NTRKR3, TKT, TYRO10
Database cross-references and differences (RAF-indexed):
- Uniprot Q16832
Domains in SCOPe 2.08: d6feri_
Chain 'J':
Compound: Discoidin domain-containing receptor 2
Species: Homo sapiens [TaxId:9606]
Gene: DDR2, NTRKR3, TKT, TYRO10
Database cross-references and differences (RAF-indexed):
- Uniprot Q16832 (0-End)
Domains in SCOPe 2.08: d6ferj_
Chain 'K':
Compound: Discoidin domain-containing receptor 2
Species: Homo sapiens [TaxId:9606]
Gene: DDR2, NTRKR3, TKT, TYRO10
Database cross-references and differences (RAF-indexed):
- Uniprot Q16832
Domains in SCOPe 2.08: d6ferk_
Chain 'L':
Compound: Discoidin domain-containing receptor 2
Species: Homo sapiens [TaxId:9606]
Gene: DDR2, NTRKR3, TKT, TYRO10
Database cross-references and differences (RAF-indexed):
- Uniprot Q16832
Domains in SCOPe 2.08: d6ferl_
Heterogens: D6Q

PDB Chain Sequences:

Chain 'A':
Sequence, based on SEQRES records: (download)

>6ferA (A:)
vaveefprklltfkeklgegqfgevhlcevegmekfkdkdfaldvsanqpvlvavkmlra
danknarndflkeikimsrlkdpniihllavcitddplcmiteymengdlnqflsrhepp
nssssdvrtvsytnlkfmatqiasgmkylsslnfvhrdlatrnclvgknytikiadfgms
rnlysgdyyriqgravlpirwmswesillgkfttasdvwafgvtlwetftfcqeqpysql
sdeqvientgeffrdqgrqtylpqpaicpdsvyklmlscwrrdtknrpsfqeihllllqq
gdehhhhhh