PDB entry 6fek

View 6fek on RCSB PDB site
Description: Oncogenic point mutation of RET receptor tyrosine kinase
Class: oncoprotein
Keywords: tyrosine kinase, oncogene, mutation, ONCOPROTEIN
Deposited on 2018-01-02, released 2018-02-28
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-05-02, with a file datestamp of 2018-04-27.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: N/A
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: proto-oncogene tyrosine-protein kinase receptor ret
    Species: Homo sapiens [TaxId:9606]
    Gene: RET, CDHF12, CDHR16, PTC, RET51
    Database cross-references and differences (RAF-indexed):
    • Uniprot P07949 (5-End)
      • expression tag (0-4)
      • conflict (13-14)
      • engineered mutation (189)
    Domains in SCOPe 2.08: d6feka1, d6feka2
  • Heterogens: FMT, ADN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6fekA (A:)
gplslsvdafkilaapkwefprknlvlgktlgegefgkvvkatafhlkgragyttvavkm
lkenaspselrdllsefnvlkqvnhphviklygacsqdgpllliveyakygslrgflres
rkvgpgpderaltmgdlisfawqisqgmqylaemklvhrdlaarnilvaegrkmkisdfg
lsrdvyeedfyvkrsqgripvkwmaieslfdhiyttqsdvwsfgvllweivtlggnpypg
ipperlfnllktghrmerpdncseemyrlmlqcwkqepdkrpvfadiskdlekmmvkrr

    Sequence, based on observed residues (ATOM records): (download) 
    >6fekA (A:)
gplslsvdafkilaapkwefprknlvlgktlgegefgkvvkatafhlkgragyttvavkm
lkenaspselrdllsefnvlkqvnhphviklygacsqdgpllliveyakygslrgflres
rkvgpgpderaltmgdlisfawqisqgmqylaemklvhrdlaarnilvaegrkmkisdfg
lsrdvyeedfyvkrsqgripvkwmaieslfdhiyttqsdvwsfgvllweivtlggnpypg
ipperlfnllktghrmerpdncseemyrlmlqcwkqepdkrpvfadiskdlekmmv