PDB entry 6fcx

View 6fcx on RCSB PDB site
Description: structure of human 5,10-methylenetetrahydrofolate reductase (mthfr)
Deposited on 2017-12-21, released 2018-05-16
The last revision was dated 2018-07-04, with a file datestamp of 2018-06-29.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: N/A
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Methylenetetrahydrofolate reductase
    Species: Homo sapiens [TaxId:9606]
    Gene: MTHFR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P42898 (Start-607)
      • variant (392)
      • variant (557)
      • expression tag (608-614)
  • Chain 'B':
    Compound: Methylenetetrahydrofolate reductase
    Species: Homo sapiens [TaxId:9606]
    Gene: MTHFR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P42898 (Start-607)
      • variant (392)
      • variant (557)
      • expression tag (608-611)
  • Heterogens: FAD, SAH, CIT, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6fcxA (A:)
mdperherlrekmrrrlesgdkwfsleffpprtaegavnlisrfdrmaaggplyidvtwh
pagdpgsdketssmmiastavnycgletilhmtccrqrleeitghlhkakqlglknimal
rgdpigdqweeeeggfnyavdlvkhirsefgdyfdicvagypkghpeagsfeadlkhlke
kvsagadfiitqlffeadtffrfvkactdmgitcpivpgifpiqgyhslrqlvklsklev
pqeikdviepikdndaairnygielavslcqellasglvpglhfytlnremattevlkrl
gmwtedprrplpwalsahpkrreedvrpifwasrpksyiyrtqewdefpngrwgnssspa
fgelkdyylfylkskspkeellkmwgeeltseasvfevfvlylsgepnrnghkvtclpwn
deplaaetsllkeellrvnrqgiltinsqpningkpssdpivgwgpsggyvfqkayleff
tsretaeallqvlkkyelrvnyhlvnvkgenitnapelqpnavtwgifpgreiiqptvvd
pvsfmfwkdeafalwieqwgklyeeespsrtiiqyihdnyflvnlvdndfpldnclwqvv
edtlellnaenlyfq

    Sequence, based on observed residues (ATOM records):
    >6fcxA (A:)
erherlrekmrrrlesgdkwfsleffpprtaegavnlisrfdrmaaggplyidvtwhpag
dpgsdketssmmiastavnycgletilhmtccrqrleeitghlhkakqlglknimalrgd
pfnyavdlvkhirsefgdyfdicvagypkghpeagsfeadlkhlkekvsagadfiitqlf
feadtffrfvkactdmgitcpivpgifpiqgyhslrqlvklsklevpqeikdviepikdn
daairnygielavslcqellasglvpglhfytlnremattevlkrlgmwtedprrplpwa
lsahpkrreedvrpifwasrpksyiyrtqewdefpngrwgnfgelkdyylfylkskspke
ellkmwgeeltseasvfevfvlylsgepnrnghkvtclpwndeplaaetsllkeellrvn
rqgiltinsqpningkpssdpivgwgpsggyvfqkaylefftsretaeallqvlkkyelr
vnyhlvnvkgenitnapelqpnavtwgifpgreiiqptvvdpvsfmfwkdeafalwieqw
gklyeeespsrtiiqyihdnyflvnlvdndfpldnclwqvvedtlellnaenlyfq

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6fcxB (B:)
mdperherlrekmrrrlesgdkwfsleffpprtaegavnlisrfdrmaaggplyidvtwh
pagdpgsdketssmmiastavnycgletilhmtccrqrleeitghlhkakqlglknimal
rgdpigdqweeeeggfnyavdlvkhirsefgdyfdicvagypkghpeagsfeadlkhlke
kvsagadfiitqlffeadtffrfvkactdmgitcpivpgifpiqgyhslrqlvklsklev
pqeikdviepikdndaairnygielavslcqellasglvpglhfytlnremattevlkrl
gmwtedprrplpwalsahpkrreedvrpifwasrpksyiyrtqewdefpngrwgnssspa
fgelkdyylfylkskspkeellkmwgeeltseasvfevfvlylsgepnrnghkvtclpwn
deplaaetsllkeellrvnrqgiltinsqpningkpssdpivgwgpsggyvfqkayleff
tsretaeallqvlkkyelrvnyhlvnvkgenitnapelqpnavtwgifpgreiiqptvvd
pvsfmfwkdeafalwieqwgklyeeespsrtiiqyihdnyflvnlvdndfpldnclwqvv
edtlellnaenlyfq

    Sequence, based on observed residues (ATOM records):
    >6fcxB (B:)
rherlrekmrrrlesgdkwfsleffpprtaegavnlisrfdrmaaggplyidvtwhpagd
pgsdketssmmiastavnycgletilhmtccrqrleeitghlhkakqlglknimalrgdp
fnyavdlvkhirsefgdyfdicvagypkghpgsfeadlkhlkekvsadfiitqlffeadt
ffrfvkactdmgitcpivpgifpiqgyhslrqlvklsklevpqeikdviepikdndaair
nygielavslcqellasgglhfytlnremattevlkrlgmwtedprrplpwalsahpkrr
eedvrpifwasrpksyiyrtqewdefpngrwgnssspafgelkdyylfylkskspkeell
kmwgeeltseasvfevfvlylsgepnrnghkvtclpwndeplaaetsllkeellrvnrqg
iltinsqpningkpssdpivgwgpsggyvfqkaylefftsretaeallqvlkkyelrvny
hlvnvkgenitnapelqpnavtwgifpgreiiqptvvdpvsfmfwkdeafalwieqwgkl
yeeespsrtiiqyihdnyflvnlvdndfpldnclwqvvedtlellnaenl