PDB entry 6fbv

View 6fbv on RCSB PDB site
Description: single particle cryo em structure of mycobacterium tuberculosis rna polymerase in complex with fidaxomicin
Deposited on 2017-12-19, released 2018-02-28
The last revision was dated 2019-12-11, with a file datestamp of 2019-12-06.
Experiment type: EM
Resolution: 3.5 Å
R-factor: N/A
AEROSPACI score: 0.08 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: DNA-directed RNA polymerase subunit alpha
    Species: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [TaxId:83332]
    Gene: rpoA, Rv3457c, MTCY13E12.10c
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: DNA-directed RNA polymerase subunit alpha
    Species: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [TaxId:83332]
    Gene: rpoA, Rv3457c, MTCY13E12.10c
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: DNA-directed RNA polymerase subunit beta
    Species: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [TaxId:83332]
    Gene: rpoB, Rv0667, MTCI376.08c
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: DNA-directed RNA polymerase subunit beta'
    Species: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [TaxId:83332]
    Gene: rpoC, Rv0668, MTCI376.07c
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: DNA-directed RNA polymerase subunit omega
    Species: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [TaxId:83332]
    Gene: rpoZ, Rv1390, MTCY21B4.07
    Database cross-references and differences (RAF-indexed):
  • Chain 'F':
    Compound: RNA polymerase sigma factor SigA
    Species: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) [TaxId:83332]
    Gene: sigA, mysA, rpoD, rpoV, Rv2703, MTCY05A6.24
    Database cross-references and differences (RAF-indexed):
  • Heterogens: FI8, ZN, MG, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6fbvA (A:)
    mllsqrptlsedvltdnrsqfvieplepgfgytlgnslrrtllssipgaavtsiridgvl
    hefttvpgvkedvteiilnlkslvvsseedepvtmylrkqgpgevtagdivppagvtvhn
    pgmhiatlndkgklevelvvergrgyvpavqnrasgaeigripvdsiyspvlkvtykvda
    trveqrtdfdklildvetknsisprdalasagktlvelfglarelnveaegieigpspae
    adhiasfalpiddldltvrsynclkregvhtvgelvartesdlldirnfgqksidevkik
    lhqlglslkdsppsfdpsevagydvatgtwstegaydeqdyaeteql
    

    Sequence, based on observed residues (ATOM records):
    >6fbvA (A:)
    sqrptlsedvltdnrsqfvieplepgfgytlgnslrrtllssipgaavtsiridgvlhef
    ttvpgvkedvteiilnlkslvvsseedepvtmylrkqgpgevtagdivppagvtvhnpgm
    hiatlndkgklevelvvergrgyvpavqnrasgaeigripvdsiyspvlkvtykvdatrv
    eqrtdfdklildvetknsisprdalasagktlvelfglareln
    

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6fbvB (B:)
    mllsqrptlsedvltdnrsqfvieplepgfgytlgnslrrtllssipgaavtsiridgvl
    hefttvpgvkedvteiilnlkslvvsseedepvtmylrkqgpgevtagdivppagvtvhn
    pgmhiatlndkgklevelvvergrgyvpavqnrasgaeigripvdsiyspvlkvtykvda
    trveqrtdfdklildvetknsisprdalasagktlvelfglarelnveaegieigpspae
    adhiasfalpiddldltvrsynclkregvhtvgelvartesdlldirnfgqksidevkik
    lhqlglslkdsppsfdpsevagydvatgtwstegaydeqdyaeteql
    

    Sequence, based on observed residues (ATOM records):
    >6fbvB (B:)
    lsqrptlsedvltdnrsqfvieplepgfgytlgnslrrtllssipgaavtsiridgvlhe
    fttvpgvkedvteiilnlkslvvsseedepvtmylrkqgpgevtagdivppagvtvhnpg
    mhiatlndkgklevelvvergrgyvpavqnrasgaeigripvdsiyspvlkvtykvdatr
    veqrtdfdklildvetknsisprdalasagktlvelfglarelnveaegi
    

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6fbvC (C:)
    mlegciladsrqsktaaspspsrpqsssnnsvpgapnrvsfaklreplevpglldvqtds
    fewligsprwresaaergdvnpvggleevlyelspiedfsgsmslsfsdprfddvkapvd
    eckdkdmtyaaplfvtaefinnntgeiksqtvfmgdfpmmtekgtfiingtervvvsqlv
    rspgvyfdetidkstdktlhsvkvipsrgawlefdvdkrdtvgvridrkrrqpvtvllka
    lgwtseqiverfgfseimrstlekdntvgtdealldiyrklrpgepptkesaqtllenlf
    fkekrydlarvgrykvnkklglhvgepitsstlteedvvatieylvrlhegqttmtvpgg
    vevpvetddidhfgnrrlrtvgeliqnqirvgmsrmervvrermttqdveaitpqtlini
    rpvvaaikeffgtsqlsqfmdqnnplsglthkrrlsalgpgglsreraglevrdvhpshy
    grmcpietpegpnigligslsvyarvnpfgfietpyrkvvdgvvsdeivyltadeedrhv
    vaqanspidadgrfveprvlvrrkageveyvpssevdymdvsprqmvsvatamipflehd
    danralmganmqrqavplvrseaplvgtgmelraaidagdvvvaeesgvieevsadyitv
    mhdngtrrtyrmrkfarsnhgtcanqcpivdagdrveagqviadgpctddgemalgknll
    vaimpweghnyedaiilsnrlveedvltsihieeheidardtklgaeeitrdipnisdev
    ladldergivrigaevrdgdilvgkvtpkgeteltpeerllraifgekarevrdtslkvp
    hgesgkvigirvfsrededelpagvnelvrvyvaqkrkisdgdklagrhgnkgvigkilp
    vedmpfladgtpvdiilnthgvprrmnigqilethlgwcahsgwkvdaakgvpdwaarlp
    delleaqpnaivstpvfdgaqeaelqgllsctlpnrdgdvlvdadgkamlfdgrsgepfp
    ypvtvgymyimklhhlvddkiharstgpysmitqqplggkaqfggqrfgemecwamqayg
    aaytlqelltiksddtvgrvkvyeaivkgenipepgipesfkvllkelqslclnvevlss
    dgaaielregededleraaanlginlsrnesasvedla
    

    Sequence, based on observed residues (ATOM records):
    >6fbvC (C:)
    snnsvpgapnrvsfaklreplevpglldvqtdsfewligsprwresaaergdvnpvggle
    evlyelspiedfsgsmslsfsdprfddvkapvdeckdkdmtyaaplfvtaefinnntgei
    ksqtvfmgdfpmmtekgtfiingtervvvsqlvrspgvyfdetidkstdktlhsvkvips
    rgawlefdvdkrdtvgvridrkrrqpvtvllkalgwtseqiverfgfseimrstlekdnt
    vgtdealldiyrklrpgepptkesaqtllenlffkekrydlarvgrykvnkklglhvgep
    itsstlteedvvatieylvrlhegqttmtvpggvevpvetddidhfgnrrlrtvgeliqn
    qirvgmsrmervvrermttqdveaitpqtlinirpvvaaikeffgtsqlsqfmdqnnpls
    glthkrrlsalgpgglsreraglevrdvhpshygrmcpietpegpnigligslsvyarvn
    pfgfietpyrkvvdgvvsdeivyltadeedrhvvaqanspidadgrfveprvlvrrkage
    veyvpssevdymdvsprqmvsvatamipflehddanralmganmqrqavplvrseaplvg
    tgmelraaidagdvvvaeesgvieevsadyitvmhdngtrrtyrmrkfarsnhgtcanqc
    pivdagdrveagqviadgpctddgemalgknllvaimpweghnyedaiilsnrlveedvl
    tsihieeheidardtklgaeeitrdipnisdevladldergivrigaevrdgdilvgkvt
    pkgeteltpeerllraifgekarevrdtslkvphgesgkvigirvfsrededelpagvne
    lvrvyvaqkrkisdgdklagrhgnkgvigkilpvedmpfladgtpvdiilnthgvprrmn
    igqilethlgwcahsgwkvdaakgvpdwaarlpdelleaqpnaivstpvfdgaqeaelqg
    llsctlpnrdgdvlvdadgkamlfdgrsgepfpypvtvgymyimklhhlvddkiharstg
    pysmitqqplggkaqfggqrfgemecwamqaygaaytlqelltiksddtvgrvkvyeaiv
    kgenipepgipesfkvllkelqslclnvevlssdgaai
    

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6fbvD (D:)
    mldvnffdelriglataedirqwsygevkkpetinyrtlkpekdglfcekifgptrdwec
    ycgkykrvrfkgiicercgvevtrakvrrermghielaapvthiwyfkgvpsrlgylldl
    apkdlekiiyfaayvitsvdeemrhnelstleaemaverkavedqrdgelearaqklead
    laeleaegakadarrkvrdggeremrqirdraqreldrlediwstftklapkqlivdenl
    yrelvdrygeyftgamgaesiqklienfdidaeaeslrdvirngkgqkklralkrlkvva
    afqqsgnspmgmvldavpvippelrpmvqldggrfatsdlndlyrrvinrnnrlkrlidl
    gapeiivnnekrmlqesvdalfdngrrgrpvtgpgnrplkslsdllkgkqgrfrqnllgk
    rvdysgrsvivvgpqlklhqcglpklmalelfkpfvmkrlvdlnhaqniksakrmverqr
    pqvwdvleeviaehpvllnraptlhrlgiqafepmlvegkaiqlhplvceafnadfdgdq
    mavhlplsaeaqaearilmlssnnilspasgrplamprldmvtglyylttevpgdtgeyq
    pasgdhpetgvysspaeaimaadrgvlsvrakikvrltqlrppveieaelfghsgwqpgd
    awmaettlgrvmfnellplgypfvnkqmhkkvqaaiindlaerypmivvaqtvdklkdag
    fywatrsgvtvsmadvlvpprkkeildhyeeradkvekqfqrgalnhdernealveiwke
    atdevgqalrehypddnpiitivdsgatgnftqtrtlagmkglvtnpkgefiprpvkssf
    regltvleyfinthgarkgladtalrtadsgyltrrlvdvsqdvivrehdcqtergivve
    laerapdgtlirdpyietsayartlgtdavdeagnvivergqdlgdpeidallaagitqv
    kvrsvltcatstgvcatcygrsmatgklvdigeavgivaaqsigepgtqltmrtfhqggv
    geditgglprvqelfearvprgkapiadvtgrvrledgerfykitivpddggeevvydki
    skrqrlrvfkhedgservlsdgdhvevgqqlmegsadphevlrvqgprevqihlvrevqe
    vyraqgvsihdkhievivrqmlrrvtiidsgsteflpgslidraefeaenrrvvaeggep
    aagrpvlmgitkaslatdswlsaasfqettrvltdaaincrsdklnglkenviigklipa
    gtginryrniavqpteearaaaytipsyedqyyspdfgaatgaavplddygysdyr
    

    Sequence, based on observed residues (ATOM records):
    >6fbvD (D:)
    dvnffdelriglataedirqwsygevkkpetinyrtlkpekdglfcekifgptrdwecyc
    gkykrvrfkgiicercgvevtrakvrrermghielaapvthiwyfkgvpsrlgylldlap
    kdlekiiyfaayvitsvdeemrhnelstleaemaverkavedqrdgelearaqkleadla
    eleaegakadarrkvrdggeremrqirdraqreldrlediwstftklapkqlivdenlyr
    elvdrygeyftgamgaesiqklienfdidaeaeslrdvirngkgqkklralkrlkvvaaf
    qqsgnspmgmvldavpvippelrpmvqldggrfatsdlndlyrrvinrnnrlkrlidlga
    peiivnnekrmlqesvdalfdngrrgrpvtgpgnrplkslsdllkgkqgrfrqnllgkrv
    dysgrsvivvgpqlklhqcglpklmalelfkpfvmkrlvdlnhaqniksakrmverqrpq
    vwdvleeviaehpvllnraptlhrlgiqafepmlvegkaiqlhplvceafnadfdgdqma
    vhlplsaeaqaearilmlssnnilspasgrplamprldmvtglyylttevpgdtgeyqpa
    sgdhpetgvysspaeaimaadrgvlsvrakikvrltqlrppveieaelfghsgwqpgdaw
    maettlgrvmfnellplgypfvnkqmhkkvqaaiindlaerypmivvaqtvdklkdagfy
    watrsgvtvsmadvlvpprkkeildhyeeradkvekqfqrgalnhdernealveiwkeat
    devgqalrehypddnpiitivdsgatgnftqtrtlagmkglvtnpkgefiprpvkssfre
    gltvleyfinthgarkgladtalrtadsgyltrrlvdvsqdvivrehdcqtergivvela
    erapdgtlirdpyietsayartlgtdavdeagnvivergqdlgdpeidallaagitqvkv
    rsvltcatstgvcatcygrsmatgklvdigeavgivaaqsigepgtqltmrditgglprv
    qelfearvprgkapiadvtgrvrledgerfykitivpddggeevvydkiskrqrlrvfkh
    edgservlsdgdhvevgqqlmegsadphevlrvqgprevqihlvrevqevyraqgvsihd
    khievivrqmlrrvtiidsgsteflpgslidraefeaenrrvvaeggepaagrpvlmgit
    kaslatdswlsaasfqettrvltdaaincrsdklnglkenviigklipagtginryrnia
    vqpteearaa
    

  • Chain 'E':
    Sequence, based on SEQRES records:
    >6fbvE (E:)
    msisqsdaslaavpavdqfdpssgasggydtplgitnppidelldrvsskyalviyaakr
    arqindyynqlgegileyvgplvepglqekplsialreihadllehtege
    

    Sequence, based on observed residues (ATOM records):
    >6fbvE (E:)
    gydtplgitnppidelldrvsskyalviyaakrarqindyynqlgegileyvgplvepgl
    qekplsialreihadllehtege
    

  • Chain 'F':
    Sequence, based on SEQRES records:
    >6fbvF (F:)
    maatkastatdepvkrtatkspaasasgaktgakrtaaksasgsppakratkpaarsvkp
    asapqdtttstipkrktraaaksaaakapsarghatkprapkdaqheaatdpedaldsve
    eldaepdldvepgedldldaadlnlddleddvapdadddldsgddedhedleaeaavapg
    qtadddeeiaeptekdkasgdfvwdedesealrqarkdaeltasadsvraylkqigkval
    lnaeeevelakrieaglyatqlmtelsergeklpaaqrrdmmwicrdgdraknhlleanl
    rlvvslakrytgrgmafldliqegnlgliravekfdytkgykfstyatwwirqaitrama
    dqartiripvhmvevinklgriqrellqdlgreptpeelakemditpekvleiqqyarep
    isldqtigdegdsqlgdfiedseavvavdavsftllqdqlqsvldtlsereagvvrlrfg
    ltdgqprtldeigqvygvtrerirqiesktmsklrhpsrsqvlrdyld
    

    Sequence, based on observed residues (ATOM records):
    >6fbvF (F:)
    adsvraylkqigkvallnaeeevelakrieaglyatqlmtelsergeklpaaqrrdmmwi
    crdgdraknhlleanlrlvvslakrytgrgmafldliqegnlgliravekfdytkgykfs
    tyatwwirqaitramadqartiripvhmvevinklgriqrellqdlgreptpeelakemd
    itpekvleiqqyarepisldqqlgdfiedsvavdavsftllqdqlqsvldtlsereagvv
    rlrfgltdgqprtldeigqvygvtrerirqiesktmsklrhpsrsqvlrdyld