PDB entry 6fax

View 6fax on RCSB PDB site
Description: Complex of Human CD40 Ectodomain with Lob 7.4 Fab
Class: immune system
Keywords: CD40, engineered Fab, agonist, mAb, immune system
Deposited on 2017-12-18, released 2018-02-07
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-04-18, with a file datestamp of 2018-04-13.
Experiment type: XRAY
Resolution: 2.99 Å
R-factor: N/A
AEROSPACI score: 0.13 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'H':
    Compound: Lob 7.4 heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6FAX (0-End)
    Domains in SCOPe 2.08: d6faxh_
  • Chain 'L':
    Compound: Lob 7.4 light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6FAX (0-End)
    Domains in SCOPe 2.08: d6faxl1, d6faxl2
  • Chain 'R':
    Compound: Tumor necrosis factor receptor superfamily member 5
    Species: Homo sapiens [TaxId:9606]
    Gene: CD40, TNFRSF5
    Database cross-references and differences (RAF-indexed):
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >6faxH (H:)
evqlqqsgpdlvkpgasvkiscktsgytfteyimhwvkqshgkslewiggiipnnggtsy
nqkfkdkatmtvdkssstgymelrsltsedsavyyctrrevygrnyyaldywgqgtlvtv
ssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlq
ssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepkccdkthtcppcpapell

    Sequence, based on observed residues (ATOM records): (download) 
    >6faxH (H:)
evqlqqsgpdlvkpgasvkiscktsgytfteyimhwvkqshgkslewiggiipnnggtsy
nqkfkdkatmtvdkssstgymelrsltsedsavyyctrrevygrnyyaldywgqgtlvtv
ssastkgpsvfplapstaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglysl
ssvvtvpssslgtqtyicnvnhkpsntkvdkkvepk

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >6faxL (L:)
diqmtqttsslsaslgdrvtitcsasqginnylnwyqqkpdgtvklliyytsslhsgvps
rfsgsgsgtdysltisnlepediatyycqqysnlpytfgggtkleikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records): (download) 
    >6faxL (L:)
diqmtqttsslsaslgdrvtitcsasqginnylnwyqqkpdgtvklliyytsslhsgvps
rfsgsgsgtdysltisnlepediatyycqqysnlpytfgggtkleikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnr

  • Chain 'R':
    No sequence available.