PDB entry 6fa3

View 6fa3 on RCSB PDB site
Description: Antibody derived (Abd-6) small molecule binding to KRAS.
Class: oncoprotein
Keywords: Abd-4, inhibitor, KRAS, ONCOPROTEIN
Deposited on 2017-12-15, released 2018-08-22
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-08-22, with a file datestamp of 2018-08-17.
Experiment type: XRAY
Resolution: 1.82 Å
R-factor: N/A
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: GTPase KRas
    Species: Homo sapiens [TaxId:9606]
    Gene: KRAS, KRAS2, RASK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01116 (4-171)
      • expression tag (1-3)
      • engineered mutation (64)
    Domains in SCOPe 2.08: d6fa3a1, d6fa3a2
  • Chain 'B':
    Compound: GTPase KRas
    Species: Homo sapiens [TaxId:9606]
    Gene: KRAS, KRAS2, RASK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01116 (4-171)
      • expression tag (0-3)
      • engineered mutation (64)
    Domains in SCOPe 2.08: d6fa3b1, d6fa3b2
  • Chain 'C':
    Compound: GTPase KRas
    Species: Homo sapiens [TaxId:9606]
    Gene: KRAS, KRAS2, RASK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01116 (4-171)
      • expression tag (0-3)
      • engineered mutation (64)
    Domains in SCOPe 2.08: d6fa3c1, d6fa3c2
  • Chain 'D':
    Compound: GTPase KRas
    Species: Homo sapiens [TaxId:9606]
    Gene: KRAS, KRAS2, RASK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01116 (4-171)
      • expression tag (0-3)
      • engineered mutation (64)
    Domains in SCOPe 2.08: d6fa3d1, d6fa3d2
  • Chain 'E':
    Compound: GTPase KRas
    Species: Homo sapiens [TaxId:9606]
    Gene: KRAS, KRAS2, RASK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01116 (4-171)
      • expression tag (0-3)
      • engineered mutation (64)
    Domains in SCOPe 2.08: d6fa3e1, d6fa3e2
  • Chain 'F':
    Compound: GTPase KRas
    Species: Homo sapiens [TaxId:9606]
    Gene: KRAS, KRAS2, RASK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01116 (4-End)
      • expression tag (1-3)
      • engineered mutation (64)
    Domains in SCOPe 2.08: d6fa3f1, d6fa3f2
  • Heterogens: MG, GNP, D1Z, DMS, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6fa3A (A:)
afqgmteyklvvvgaggvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldil
dtagheeysamrdqymrtgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgn
kcdlpsrtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhke

    Sequence, based on observed residues (ATOM records): (download) 
    >6fa3A (A:)
fqgmteyklvvvgaggvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldild
tagheeysamrdqymrtgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgnk
cdlpsrtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhke

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6fa3B (B:)
afqgmteyklvvvgaggvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldil
dtagheeysamrdqymrtgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgn
kcdlpsrtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhke

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6fa3C (C:)
afqgmteyklvvvgaggvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldil
dtagheeysamrdqymrtgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgn
kcdlpsrtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhke

    Sequence, based on observed residues (ATOM records): (download) 
    >6fa3C (C:)
afqgmteyklvvvgaggvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldil
dtaghesamrdqymrtgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgnkc
dlpsrtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhke

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6fa3D (D:)
afqgmteyklvvvgaggvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldil
dtagheeysamrdqymrtgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgn
kcdlpsrtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhke

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >6fa3E (E:)
afqgmteyklvvvgaggvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldil
dtagheeysamrdqymrtgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgn
kcdlpsrtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhke

    Sequence, based on observed residues (ATOM records): (download) 
    >6fa3E (E:)
afqgmteyklvvvgaggvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldil
dtagherdqymrtgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgnkcdlp
srtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhke

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >6fa3F (F:)
afqgmteyklvvvgaggvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldil
dtagheeysamrdqymrtgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgn
kcdlpsrtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhke

    Sequence, based on observed residues (ATOM records): (download) 
    >6fa3F (F:)
fqgmteyklvvvgaggvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldild
taghmrdqymrtgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgnkcdlps
rtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhk