PDB entry 6f76

View 6f76 on RCSB PDB site
Description: Antibody derived (Abd-8) small molecule binding to KRAS.
Class: oncoprotein
Keywords: Abd-8, inhibitor, KRAS, ONCOPROTEIN
Deposited on 2017-12-07, released 2018-08-08
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-08-08, with a file datestamp of 2018-08-03.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: N/A
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: GTPase KRas
    Species: Homo sapiens [TaxId:9606]
    Gene: KRAS, KRAS2, RASK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01116 (4-End)
      • expression tag (0-3)
      • engineered mutation (64)
    Domains in SCOPe 2.08: d6f76a1, d6f76a2
  • Chain 'B':
    Compound: GTPase KRas
    Species: Homo sapiens [TaxId:9606]
    Gene: KRAS, KRAS2, RASK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01116 (4-End)
      • expression tag (0-3)
      • engineered mutation (64)
    Domains in SCOPe 2.08: d6f76b1, d6f76b2
  • Chain 'C':
    Compound: GTPase KRas
    Species: Homo sapiens [TaxId:9606]
    Gene: KRAS, KRAS2, RASK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01116 (4-End)
      • expression tag (0-3)
    Domains in SCOPe 2.08: d6f76c1, d6f76c2
  • Chain 'D':
    Compound: GTPase KRas
    Species: Homo sapiens [TaxId:9606]
    Gene: KRAS, KRAS2, RASK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01116 (4-End)
      • expression tag (0-3)
      • engineered mutation (64)
    Domains in SCOPe 2.08: d6f76d1, d6f76d2
  • Chain 'E':
    Compound: GTPase KRas
    Species: Homo sapiens [TaxId:9606]
    Gene: KRAS, KRAS2, RASK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01116 (4-172)
      • expression tag (0-3)
      • engineered mutation (64)
    Domains in SCOPe 2.08: d6f76e1, d6f76e2
  • Chain 'F':
    Compound: GTPase KRas
    Species: Homo sapiens [TaxId:9606]
    Gene: KRAS, KRAS2, RASK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01116 (4-End)
      • expression tag (0-3)
      • engineered mutation (64)
    Domains in SCOPe 2.08: d6f76f1, d6f76f2
  • Heterogens: MG, GNP, CVK, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6f76A (A:)
afqgmteyklvvvgaggvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldil
dtagheeysamrdqymrtgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgn
kcdlpsrtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhkek

    Sequence, based on observed residues (ATOM records): (download) 
    >6f76A (A:)
afqgmteyklvvvgaggvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldil
dtagheeysamrdqymrtgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgn
kcdlpsrtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhke

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6f76B (B:)
afqgmteyklvvvgaggvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldil
dtagheeysamrdqymrtgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgn
kcdlpsrtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhkek

    Sequence, based on observed residues (ATOM records): (download) 
    >6f76B (B:)
afqgmteyklvvvgaggvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldil
dtagheeysamrdqymrtgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgn
kcdlpsrtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhke

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6f76C (C:)
afqgmteyklvvvgaggvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldil
dtagheeysamrdqymrtgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgn
kcdlpsrtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhkek

    Sequence, based on observed residues (ATOM records): (download) 
    >6f76C (C:)
afqgmteyklvvvgaggvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldil
dtagamrdqymrtgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgnkcdlp
srtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhke

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6f76D (D:)
afqgmteyklvvvgaggvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldil
dtagheeysamrdqymrtgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgn
kcdlpsrtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhkek

    Sequence, based on observed residues (ATOM records): (download) 
    >6f76D (D:)
afqgmteyklvvvgaggvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldil
dtaghrdqymrtgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgnkcdlps
rtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhk

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >6f76E (E:)
afqgmteyklvvvgaggvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldil
dtagheeysamrdqymrtgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgn
kcdlpsrtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhkek

    Sequence, based on observed residues (ATOM records): (download) 
    >6f76E (E:)
afqgmteyklvvvgaggvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldil
dtagherdqymrtgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgnkcdlp
srtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhkek

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >6f76F (F:)
afqgmteyklvvvgaggvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldil
dtagheeysamrdqymrtgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgn
kcdlpsrtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhkek

    Sequence, based on observed residues (ATOM records): (download) 
    >6f76F (F:)
afqgmteyklvvvgaggvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldil
dtaghamrdqymrtgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgnkcdl
psrtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhke