PDB entry 6f22
View 6f22 on RCSB PDB site
Description: Complex between MTH1 and compound 29 (a 4-amino-2,7-diazaindole derivative)
Class: hydrolase
Keywords: nudix, nucleotide hydrolase, inhibitor, oncology, hydrolase
Deposited on
2017-11-23, released
2018-03-07
The last revision prior to the SCOPe 2.07 freeze date was dated
2018-04-04, with a file datestamp of
2018-03-29.
Experiment type: XRAY
Resolution: 1.55 Å
R-factor: N/A
AEROSPACI score: 0.47
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: 7,8-dihydro-8-oxoguanine triphosphatase
Species: Homo sapiens [TaxId:9606]
Gene: NUDT1, MTH1
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.07: d6f22a1, d6f22a2 - Chain 'B':
Compound: 7,8-dihydro-8-oxoguanine triphosphatase
Species: Homo sapiens [TaxId:9606]
Gene: NUDT1, MTH1
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.07: d6f22b_ - Heterogens: C9B, SO4, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>6f22A (A:)
gshmgasrlytlvlvlqpqrvllgmkkrgfgagrwngfggkvqegetiedgarrelqees
gltvdalhkvgqivfefvgepelmdvhvfctdsiqgtpvesdemrpcwfqldqipfkdmw
pddsywfplllqkkkfhgyfkfqgqdtildytlrevdtv
Sequence, based on observed residues (ATOM records): (download)
>6f22A (A:)
hmgasrlytlvlvlqpqrvllgmkkrgfgagrwngfggkvqegetiedgarrelqeesgl
tvdalhkvgqivfefvgepelmdvhvfctdsiqgtpvesdemrpcwfqldqipfkdmwpd
dsywfplllqkkkfhgyfkfqgqdtildytlrevdtv
- Chain 'B':
Sequence, based on SEQRES records: (download)
>6f22B (B:)
gshmgasrlytlvlvlqpqrvllgmkkrgfgagrwngfggkvqegetiedgarrelqees
gltvdalhkvgqivfefvgepelmdvhvfctdsiqgtpvesdemrpcwfqldqipfkdmw
pddsywfplllqkkkfhgyfkfqgqdtildytlrevdtv
Sequence, based on observed residues (ATOM records): (download)
>6f22B (B:)
asrlytlvlvlqpqrvllgmkkrgfgagrwngfggkvqegetiedgarrelqeesgltvd
alhkvgqivfefvgepelmdvhvfctdsiqgtpvesdemrpcwfqldqipfkdmwpddsy
wfplllqkkkfhgyfkfqgqdtildytlrevdtv