PDB entry 6f20

View 6f20 on RCSB PDB site
Description: Complex between MTH1 and compound 1 (a 7-azaindole-4-ester derivative)
Class: hydrolase
Keywords: nudix, nucleotide hydrolase, inhibitor, oncology, hydrolase
Deposited on 2017-11-23, released 2018-03-07
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-04-04, with a file datestamp of 2018-03-29.
Experiment type: XRAY
Resolution: 2 Å
R-factor: N/A
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 7,8-dihydro-8-oxoguanine triphosphatase
    Species: Homo sapiens [TaxId:9606]
    Gene: NUDT1, MTH1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6f20a_
  • Chain 'B':
    Compound: 7,8-dihydro-8-oxoguanine triphosphatase
    Species: Homo sapiens [TaxId:9606]
    Gene: NUDT1, MTH1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6f20b_
  • Heterogens: C9E, SO4, ACT, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6f20A (A:)
gshmgasrlytlvlvlqpqrvllgmkkrgfgagrwngfggkvqegetiedgarrelqees
gltvdalhkvgqivfefvgepelmdvhvfctdsiqgtpvesdemrpcwfqldqipfkdmw
pddsywfplllqkkkfhgyfkfqgqdtildytlrevdtv

    Sequence, based on observed residues (ATOM records): (download) 
    >6f20A (A:)
mgasrlytlvlvlqpqrvllgmkkrgfgagrwngfggkvqegetiedgarrelqeesglt
vdalhkvgqivfefvgepelmdvhvfctdsiqgtpvesdemrpcwfqldqipfkdmwpdd
sywfplllqkkkfhgyfkfqgqdtildytlrevdtv

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6f20B (B:)
gshmgasrlytlvlvlqpqrvllgmkkrgfgagrwngfggkvqegetiedgarrelqees
gltvdalhkvgqivfefvgepelmdvhvfctdsiqgtpvesdemrpcwfqldqipfkdmw
pddsywfplllqkkkfhgyfkfqgqdtildytlrevdtv

    Sequence, based on observed residues (ATOM records): (download) 
    >6f20B (B:)
srlytlvlvlqpqrvllgmkkrgfgagrwngfggkvqegetiedgarrelqeesgltvda
lhkvgqivfefvgepelmdvhvfctdsiqgtpvesdemrpcwfqldqipfkdmwpddsyw
fplllqkkkfhgyfkfqgqdtildytlrevdtv