PDB entry 6f0x

View 6f0x on RCSB PDB site
Description: cryo-em structure of trip13 in complex with atp gamma s, p31comet, c- mad2 and cdc20
Deposited on 2017-11-20, released 2018-05-02
The last revision was dated 2020-12-02, with a file datestamp of 2020-11-27.
Experiment type: EM
Resolution: 4.6 Å
R-factor: N/A
AEROSPACI score: 0.1 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Pachytene checkpoint protein 2 homolog
    Species: Homo sapiens [TaxId:9606]
    Gene: TRIP13, PCH2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q15645
      • conflict (252)
  • Chain 'B':
    Compound: Pachytene checkpoint protein 2 homolog
    Species: Homo sapiens [TaxId:9606]
    Gene: TRIP13, PCH2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q15645
      • conflict (252)
  • Chain 'C':
    Compound: Pachytene checkpoint protein 2 homolog
    Species: Homo sapiens [TaxId:9606]
    Gene: TRIP13, PCH2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q15645
      • conflict (252)
  • Chain 'D':
    Compound: Pachytene checkpoint protein 2 homolog
    Species: Homo sapiens [TaxId:9606]
    Gene: TRIP13, PCH2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q15645
      • conflict (252)
  • Chain 'E':
    Compound: Pachytene checkpoint protein 2 homolog
    Species: Homo sapiens [TaxId:9606]
    Gene: TRIP13, PCH2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q15645
      • conflict (252)
  • Chain 'F':
    Compound: Pachytene checkpoint protein 2 homolog
    Species: Homo sapiens [TaxId:9606]
    Gene: TRIP13, PCH2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q15645
      • conflict (252)
  • Chain 'P':
    Compound: MAD2L1-binding protein
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'Q':
    Compound: Cell division cycle protein 20 homolog
    Species: Homo sapiens [TaxId:9606]
    Gene: CDC20
    Database cross-references and differences (RAF-indexed):
  • Chain 'Z':
    Compound: mitotic spindle assembly checkpoint protein mad2a
    Species: Homo sapiens [TaxId:9606]
    Gene: MAD2L1, MAD2
    Database cross-references and differences (RAF-indexed):
  • Heterogens: AGS

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6f0xA (A:)
mdeavgdlkqalpcvaesptvhvevhqrgsstakkedinlsvrkllnrhnivfgdytwte
fdepfltrnvqsvsiidtelkvkdsqpidlsactvalhifqlnedgpssenleeetenii
aanhwvlpaaefhglwdslvydvevkshlldyvmttllfsdknvnsnlitwnrvvllhgp
pgtgktslckalaqkltirlssryrygqlieinshslfskwfsesgklvtkmfqkiqdli
ddkdalvfvlidqvesltaarnacragtepsdairvvnavltqidqikrhsnvvilttsn
itekidvafvdradikqyigppsaaaifkiylscleelmkcqiiyprqqlltlrelemig
fiennvsklslllndisrkseglsgrvlrklpflahalyvqaptvtiegflqalslavdk
qfeerkklaayi

    Sequence, based on observed residues (ATOM records):
    >6f0xA (A:)
anhwvlpaaefhglwdslvydvevkshlldyvmttllfsdknvnsnlitwnrvvllhgpp
gtgktslckalaqkltirlssryrygqlieinshslfskwfsesgklvtkmfqkiqdlid
dkdalvfvlidqvesltaarnacragtepsdairvvnavltqidqikrhsnvvilttsni
tekidvafvdradikqyigppsaaaifkiylscleelmkcqiiyprqqlltlrelemigf
iennvsklslllndisrkseglsgrvlrklpflahalyvqaptvtiegflqalslavdkq
feerkkla

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6f0xB (B:)
mdeavgdlkqalpcvaesptvhvevhqrgsstakkedinlsvrkllnrhnivfgdytwte
fdepfltrnvqsvsiidtelkvkdsqpidlsactvalhifqlnedgpssenleeetenii
aanhwvlpaaefhglwdslvydvevkshlldyvmttllfsdknvnsnlitwnrvvllhgp
pgtgktslckalaqkltirlssryrygqlieinshslfskwfsesgklvtkmfqkiqdli
ddkdalvfvlidqvesltaarnacragtepsdairvvnavltqidqikrhsnvvilttsn
itekidvafvdradikqyigppsaaaifkiylscleelmkcqiiyprqqlltlrelemig
fiennvsklslllndisrkseglsgrvlrklpflahalyvqaptvtiegflqalslavdk
qfeerkklaayi

    Sequence, based on observed residues (ATOM records):
    >6f0xB (B:)
ptvhvevhqrgsstakkedinlsvrkllnrhnigdytwtefdepfltrnvqsvsiiddls
actvalhifqlnedgpssenleeeteniiaanhwvlpaaefhglwdslvydvevkshlld
yvmttllfsdknvnsnlitwnrvvllhgppgtgktslckalaqkltirlssryrygqlie
inshslfskwfsesgklvtkmfqkiqdliddkdalvfvlidqvesltaarnacragteps
dairvvnavltqidqikrhsnvvilttsnitekidvafvdradikqyigppsaaaifkiy
lscleelmkcqiiyprqqlltlrelemigfiennvsklslllndisrkseglsgrvlrkl
pflahalyvqaptvtiegflqalslavdkqfeerkkla

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6f0xC (C:)
mdeavgdlkqalpcvaesptvhvevhqrgsstakkedinlsvrkllnrhnivfgdytwte
fdepfltrnvqsvsiidtelkvkdsqpidlsactvalhifqlnedgpssenleeetenii
aanhwvlpaaefhglwdslvydvevkshlldyvmttllfsdknvnsnlitwnrvvllhgp
pgtgktslckalaqkltirlssryrygqlieinshslfskwfsesgklvtkmfqkiqdli
ddkdalvfvlidqvesltaarnacragtepsdairvvnavltqidqikrhsnvvilttsn
itekidvafvdradikqyigppsaaaifkiylscleelmkcqiiyprqqlltlrelemig
fiennvsklslllndisrkseglsgrvlrklpflahalyvqaptvtiegflqalslavdk
qfeerkklaayi

    Sequence, based on observed residues (ATOM records):
    >6f0xC (C:)
ptvhvevhqrgsstakkedinlsvrkllnrhnigdytwtefdepfltrnvqsvsiiddls
actvalhifqlnedgpssenleeeteniiaanhwvlpaaefhglwdslvydvevkshlld
yvmttllfsdknvnsnlitwnrvvllhgppgtgktslckalaqkltirlssryrygqlie
inshslfskwfsesgklvtkmfqkiqdliddkdalvfvlidqvesltaarnacragteps
dairvvnavltqidqikrhsnvvilttsnitekidvafvdradikqyigppsaaaifkiy
lscleelmkcqiiyprqqlltlrelemigfiennvsklslllndisrkseglsgrvlrkl
pflahalyvqaptvtiegflqalslavdkqfeerkkla

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6f0xD (D:)
mdeavgdlkqalpcvaesptvhvevhqrgsstakkedinlsvrkllnrhnivfgdytwte
fdepfltrnvqsvsiidtelkvkdsqpidlsactvalhifqlnedgpssenleeetenii
aanhwvlpaaefhglwdslvydvevkshlldyvmttllfsdknvnsnlitwnrvvllhgp
pgtgktslckalaqkltirlssryrygqlieinshslfskwfsesgklvtkmfqkiqdli
ddkdalvfvlidqvesltaarnacragtepsdairvvnavltqidqikrhsnvvilttsn
itekidvafvdradikqyigppsaaaifkiylscleelmkcqiiyprqqlltlrelemig
fiennvsklslllndisrkseglsgrvlrklpflahalyvqaptvtiegflqalslavdk
qfeerkklaayi

    Sequence, based on observed residues (ATOM records):
    >6f0xD (D:)
ptvhvevhqrgsstakkedinlsvrkllnrhnigdytwtefdepfltrnvqsvsiiddls
actvalhifqlnedgpssenleeeteniiaanhwvlpaaefhglwdslvydvevkshlld
yvmttllfsdknvnsnlitwnrvvllhgppgtgktslckalaqkltirlssryrygqlie
inshslfskwfsesgklvtkmfqkiqdliddkdalvfvlidqvesltaarnacragteps
dairvvnavltqidqikrhsnvvilttsnitekidvafvdradikqyigppsaaaifkiy
lscleelmkcqiiyprqqlltlrelemigfiennvsklslllndisrkseglsgrvlrkl
pflahalyvqaptvtiegflqalslavdkqfeerkkla

  • Chain 'E':
    Sequence, based on SEQRES records:
    >6f0xE (E:)
mdeavgdlkqalpcvaesptvhvevhqrgsstakkedinlsvrkllnrhnivfgdytwte
fdepfltrnvqsvsiidtelkvkdsqpidlsactvalhifqlnedgpssenleeetenii
aanhwvlpaaefhglwdslvydvevkshlldyvmttllfsdknvnsnlitwnrvvllhgp
pgtgktslckalaqkltirlssryrygqlieinshslfskwfsesgklvtkmfqkiqdli
ddkdalvfvlidqvesltaarnacragtepsdairvvnavltqidqikrhsnvvilttsn
itekidvafvdradikqyigppsaaaifkiylscleelmkcqiiyprqqlltlrelemig
fiennvsklslllndisrkseglsgrvlrklpflahalyvqaptvtiegflqalslavdk
qfeerkklaayi

    Sequence, based on observed residues (ATOM records):
    >6f0xE (E:)
ptvhvevhqrgsstakkedinlsvrkllnrhnigdytwtefdepfltrnvqsvsiiddls
actvalhifqlnedgpssenleeeteniiaanhwvlpaaefhglwdslvydvevkshlld
yvmttllfsdknvnsnlitwnrvvllhgppgtgktslckalaqkltirlssryrygqlie
inshslfskwfsesgklvtkmfqkiqdliddkdalvfvlidqvesltaarnacragteps
dairvvnavltqidqikrhsnvvilttsnitekidvafvdradikqyigppsaaaifkiy
lscleelmkcqiiyprqqlltlrelemigfiennvsklslllndisrkseglsgrvlrkl
pflahalyvqaptvtiegflqalslavdkqfeerkkla

  • Chain 'F':
    Sequence, based on SEQRES records:
    >6f0xF (F:)
mdeavgdlkqalpcvaesptvhvevhqrgsstakkedinlsvrkllnrhnivfgdytwte
fdepfltrnvqsvsiidtelkvkdsqpidlsactvalhifqlnedgpssenleeetenii
aanhwvlpaaefhglwdslvydvevkshlldyvmttllfsdknvnsnlitwnrvvllhgp
pgtgktslckalaqkltirlssryrygqlieinshslfskwfsesgklvtkmfqkiqdli
ddkdalvfvlidqvesltaarnacragtepsdairvvnavltqidqikrhsnvvilttsn
itekidvafvdradikqyigppsaaaifkiylscleelmkcqiiyprqqlltlrelemig
fiennvsklslllndisrkseglsgrvlrklpflahalyvqaptvtiegflqalslavdk
qfeerkklaayi

    Sequence, based on observed residues (ATOM records):
    >6f0xF (F:)
anhwvlpaaefhglwdslvydvevkshlldyvmttllfsdknvnsnlitwnrvvllhgpp
gtgktslckalaqkltirlssryrygqlieinshsklvtkmfqkiqdliddkdalvfvli
dqvesltaardairvvnavltqidqikrhsnvvilttsnitekidvafvdradikqyigp
psaaaifkiylscleelmkcqiiyrqqlltlrelemigfiennvsklslllndisrkseg
lsgrvlrklpflahalyvqaptvtiegflqalslavdkqfee

  • Chain 'P':
    Sequence, based on SEQRES records:
    >6f0xP (P:)
maapeaevlssaavpdlewyekseethasqielletsstqeplnaseafcprdcmvpvvf
pgpvsqegccqftcellkhimyqrqqlplpyeqlkhfyrkpspqaeemlkkkprattevs
srkcqqalaelesvlshledffartlvprvlillggnalspkefyeldlsllapysvdqs
lstaaclrrlfraifmadafselqapplmgtvvmaqghrncgedwfrpklnyrvpsrghk
ltvtlscgrpsirttawedyiwfqapvtfkgfre

    Sequence, based on observed residues (ATOM records):
    >6f0xP (P:)
cmvpvvfpgpvqegccqftcellkhimyqrqqlplpyeqlkhfyrkcqqalaelesvlsh
ledffartlvprvlillggnalspkefyeldlsllapdqslstaaclrrlfraifmadaf
selqapplmgtvvmaqghrncgedwfrpklnyrvpsrghkltvtlscgrpsirttawedy
iwfqapvtfkgfre

  • Chain 'Q':
    Sequence, based on SEQRES records:
    >6f0xQ (Q:)
maqfafesdlhsllqldapipnapparwqrkakeaagpapspmraanrshsagrtpgrtp
gkssskvqttpskpggdryiphrsaaqmevasfllskenqpensqtptkkehqkawalnl
ngfdveeakilrlsgkpqnapegyqnrlkvlysqkatpgssrktcryipslpdrildape
irndyylnlvdwssgnvlavaldnsvylwsassgdilqllqmeqpgeyissvawikegny
lavgtssaevqlwdvqqqkrlrnmtshsarvgslswnsyilssgsrsghihhhdvrvaeh
hvatlsghsqevcglrwapdgrhlasggndnlvnvwpsapgeggwvplqtftqhqgavka
vawcpwqsnvlatgggtsdrhiriwnvcsgaclsavdahsqvcsilwsphykelisghgf
aqnqlviwkyptmakvaelkghtsrvlsltmspdgatvasaaadetlrlwrcfeldparr
rerekasaaksslihqgir

    Sequence, based on observed residues (ATOM records):
    >6f0xQ (Q:)
kilrlsgkp

  • Chain 'Z':
    Sequence, based on SEQRES records:
    >6f0xZ (Z:)
malqlsreqgitlrgsaeivaeffsfginsilyqrgiypsetftrvqkygltllvttdle
likylnnvveqlkdwlykcsvqklvvvisniesgevlerwqfdiecdktakddsapreks
qkaiqdeirsvirqitatvtflpllevscsfdlliytdkdlvvpekweesgpqfitnsee
vrlrsftttihkvnsmvaykipvnd

    Sequence, based on observed residues (ATOM records):
    >6f0xZ (Z:)
alqlsreqgitlrgsaeivaeffsfginsilyqrgiypsetftrvqkygltllvttdlel
ikylnnvveqlkdwlykcsvqklvvvisniesgevlerwqfdiecdktakddsapreksq
kaiqdeirsvirqitatvtflpllevscsfdlliytdkdlvvpekweesgpqfitnseev
rlrsftttihkvnsmvaykipvnd