PDB entry 6ezo

View 6ezo on RCSB PDB site
Description: eukaryotic initiation factor eif2b in complex with isrib
Deposited on 2017-11-16, released 2018-03-28
The last revision was dated 2019-12-11, with a file datestamp of 2019-12-06.
Experiment type: EM
Resolution: 4.1 Å
R-factor: N/A
AEROSPACI score: 0.02 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Translation initiation factor eIF-2B subunit alpha
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Translation initiation factor eIF-2B subunit alpha
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Translation initiation factor eIF-2B subunit beta
    Species: Homo sapiens [TaxId:9606]
    Gene: EIF2B2, EIF2BB
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: Translation initiation factor eIF-2B subunit beta
    Species: Homo sapiens [TaxId:9606]
    Gene: EIF2B2, EIF2BB
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: Translation initiation factor eIF-2B subunit gamma
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'F':
    Compound: Translation initiation factor eIF-2B subunit gamma
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'G':
    Compound: Translation initiation factor eIF-2B subunit delta
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'H':
    Compound: Translation initiation factor eIF-2B subunit delta
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'I':
    Compound: Human eukaryotic initiation factor EIF2B epsilon subunits
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'J':
    Compound: Human eukaryotic initiation factor EIF2B epsilon subunits
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Heterogens: C7B

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6ezoA (A:)
mddkelieyfksqmkedpdmasavaairtlleflkrdkgetiqglranltsaietlcgvd
ssvavssggelflrfislasleysdyskckkimiergelflrrislsrnkiadlchtfik
dgatilthaysrvvlrvleaavaakkrfsvyvtesqpdlsgkkmakalchlnvpvtvvld
aavgyimekadlvivgaegvvenggiinkigtnqmavcakaqnkpfyvvaesfkfvrlfp
lnqqdvpdkfkykadtlkvaqtgqdlkeehpwvdytapslitllftdlgvltpsavsdel
iklyl

    Sequence, based on observed residues (ATOM records):
    >6ezoA (A:)
lieyfksqmkedpdmasavaairtlleflkrdkgetiqglranltsaietlcgssvavss
ggelflrfislasleysdyskckkimiergelflrrislsrnkiadlchtfikdgatilt
haysrvvlrvleaavaakkrfsvyvtesqpdlsgkkmakalchlnvpvtvvldaavgyim
ekadlvivgaegvvenggiinkigtnqmavcakaqnkpfyvvaesfkfvrlfplnqqdvp
dkfehpwvdytapslitllftdlgvltpsavsdeliklyl

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6ezoB (B:)
mddkelieyfksqmkedpdmasavaairtlleflkrdkgetiqglranltsaietlcgvd
ssvavssggelflrfislasleysdyskckkimiergelflrrislsrnkiadlchtfik
dgatilthaysrvvlrvleaavaakkrfsvyvtesqpdlsgkkmakalchlnvpvtvvld
aavgyimekadlvivgaegvvenggiinkigtnqmavcakaqnkpfyvvaesfkfvrlfp
lnqqdvpdkfkykadtlkvaqtgqdlkeehpwvdytapslitllftdlgvltpsavsdel
iklyl

    Sequence, based on observed residues (ATOM records):
    >6ezoB (B:)
lieyfksqmkedpdmasavaairtlleflkrdkgetiqglranltsaietlcgssvavss
ggelflrfislasleysdyskckkimiergelflrrislsrnkiadlchtfikdgatilt
haysrvvlrvleaavaakkrfsvyvtesqpdlsgkkmakalchlnvpvtvvldaavgyim
ekadlvivgaegvvenggiinkigtnqmavcakaqnkpfyvvaesfkfvrlfplnqqdvp
dkfehpwvdytapslitllftdlgvltpsavsdeliklyl

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6ezoC (C:)
mpgsdykdhdgdykdhdidykddddkaakgselseriesfvetlkrgggprsseemaret
lgllrqiitdhrwsnagelmelirregrrmtaaqpsettvgnmvrrvlkiireeygrlhg
rsdesdqqeslhklltsgglnedfsfhyaqlqsniieainellvelegtmeniaaqaleh
ihsnevimtigfsrtveaflkeaarkrkfhvivaecapfcqghemavnlskagiettvmt
daaifavmsrvnkviigtktilangalravtgthtlalaakhhstplivcapmfklspqf
pneedsfhkfvapeevlpftegdilekvsvhcpvfdyvppelitlfisniggnapsyiyr
lmselyhpddhvl

    Sequence, based on observed residues (ATOM records):
    >6ezoC (C:)
seriesfvetlkrgggprsseemaretlgllrqiitdhrwsnagelmelirregrrmtaa
qpsettvgnmvrrvlkiireeygrlqlqsniieainellvelegtmeniaaqalehihsn
evimtigfsrtveaflkeaarkrkfhvivaecapfcqghemavnlskagiettvmtdaai
favmsrvnkviigtktilangalravtgthtlalaakhhstplivcapmfklspqfpnee
dsfhkfvapeevlpftegdilekvsvhcpvfdyvppelitlfisniggnapsyiyrlmse
lyhpddh

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6ezoD (D:)
mpgsdykdhdgdykdhdidykddddkaakgselseriesfvetlkrgggprsseemaret
lgllrqiitdhrwsnagelmelirregrrmtaaqpsettvgnmvrrvlkiireeygrlhg
rsdesdqqeslhklltsgglnedfsfhyaqlqsniieainellvelegtmeniaaqaleh
ihsnevimtigfsrtveaflkeaarkrkfhvivaecapfcqghemavnlskagiettvmt
daaifavmsrvnkviigtktilangalravtgthtlalaakhhstplivcapmfklspqf
pneedsfhkfvapeevlpftegdilekvsvhcpvfdyvppelitlfisniggnapsyiyr
lmselyhpddhvl

    Sequence, based on observed residues (ATOM records):
    >6ezoD (D:)
seriesfvetlkrgggprsseemaretlgllrqiitdhrwsnagelmelirregrrmtaa
qpsettvgnmvrrvlkiireeygrlhqlqsniieainellvelegtmeniaaqalehihs
nevimtigfsrtveaflkeaarkrkfhvivaecapfcqghemavnlskagiettvmtdaa
ifavmsrvnkviigtktilangalravtgthtlalaakhhstplivcapmfklspqfpne
edsfhkfvapeevlpftegdilekvsvhcpvfdyvppelitlfisniggnapsyiyrlms
elyhpddh

  • Chain 'E':
    Sequence, based on SEQRES records:
    >6ezoE (E:)
mefqavvmavgggsrmtdltssipkpllpvgnkpliwyplnllervgfeevivvttrdvq
kalcaefkmkmkpdivcipddadmgtadslryiypklktdvlvlscdlitdvalhevvdl
fraydaslamlmrkgqdsiepvpgqkgkkkaveqrdfigvdstgkrllfmaneadldeel
vikgsilqkhprirfhtglvdahlyclkkyivdflmengsitsirselipylvrkqfssa
ssqqgqeekeedlkkkelksldiysfikeantlnlapydacwnacrgdrwedlsrsqvrc
yvhimkeglcsrvstlglymeanrqvpkllsalcpeeppvhssaqivskhlvgvdsligp
etqigekssikrsvigssclikdrvtitncllmnsvtveegsniqgsvicnnaviekgad
ikdcligsgqrieakakrvnevivgndqlmei

    Sequence, based on observed residues (ATOM records):
    >6ezoE (E:)
mefqavvmavgggsrmtdltssipkpllpvgnkpliwyplnllervgfeevivvttrdvq
kalcaefkmkmkpdivcipddadmgtadslryiypklktdvlvlscdlitdvalhevvdl
fraydaslamlmrkrdfigvdstgkrllfmaneadldeelvikgsilqkhprirfhtglv
dahlyclkkyivdflmengsitsirselipylvrkvhimkeglcsrvstlglymeanrqv
pkllssaqivskhlvgvdsligpetqigekssikrsvigssclikdrvtitncllmnsvt
veegsniqgsvicnnaviekgadikdcligsgqrieakakrvneviv

  • Chain 'F':
    Sequence, based on SEQRES records:
    >6ezoF (F:)
mefqavvmavgggsrmtdltssipkpllpvgnkpliwyplnllervgfeevivvttrdvq
kalcaefkmkmkpdivcipddadmgtadslryiypklktdvlvlscdlitdvalhevvdl
fraydaslamlmrkgqdsiepvpgqkgkkkaveqrdfigvdstgkrllfmaneadldeel
vikgsilqkhprirfhtglvdahlyclkkyivdflmengsitsirselipylvrkqfssa
ssqqgqeekeedlkkkelksldiysfikeantlnlapydacwnacrgdrwedlsrsqvrc
yvhimkeglcsrvstlglymeanrqvpkllsalcpeeppvhssaqivskhlvgvdsligp
etqigekssikrsvigssclikdrvtitncllmnsvtveegsniqgsvicnnaviekgad
ikdcligsgqrieakakrvnevivgndqlmei

    Sequence, based on observed residues (ATOM records):
    >6ezoF (F:)
mefqavvmavgggsrmtdltssipkpllpvgnkpliwyplnllervgfeevivvttrdvq
kalcaefkmkmkpdivcipddadmgtadslryiypklktdvlvlscdlitdvalhevvdl
fraydaslamlmrkrdfigvdstgkrllfmaneadldeelvikgsilqkhprirfhtglv
dahlyclkkyivdflmengsitsirselipylvrkvhimkeglcsrvstlglymeanrqv
pkllssaqivskhlvgvdsligpetqigekssikrsvigssclikdrvtitncllmnsvt
veegsniqgsvicnnaviekgadikdcligsgqrieakakrvneviv

  • Chain 'G':
    Sequence, based on SEQRES records:
    >6ezoG (G:)
maavavavredsgsgmkaelppgpgavgremtkeeklqlrkekkqqkkkrkeekgaepet
gsavsaaqcqvgptrelpesgiqlgtprekvpagrskaelraerrakqeaeralkqarkg
eqggpppkaspstagetpsgvkrlpeypqvddlllrrlvkkperqqvptrkdygskvslf
shlpqysrqnsltqfmsipssvihpamvrlglqysqglvsgsnarciallralqqviqdy
ttppneelsrdlvnklkpymsfltqcrplsasmhnaikflnkeitsvgsskreeeaksel
raaidryvqekivlaaqaisrfayqkisngdvilvygcsslvsrilqeawtegrrfrvvv
vdsrpwlegrhtlrslvhagvpasyllipaasyvlpevskvllgahallangsvmsrvgt
aqlalvarahnvpvlvccetykfcervqtdafvsnelddpddlqckrgehvalanwqnha
slrllnlvydvtppelvdlvitelgmipcssvpvvlrvkssdq

    Sequence, based on observed residues (ATOM records):
    >6ezoG (G:)
qvptrkdygskvslfshlpqysrqnsltqfmsipssvihpamvrlglqysqglvsgsnar
ciallralqqviqdyttppneelsrdlvnklkpymsfltqcrplsasmhnaikflnkeit
svgsskreeeakselraaidryvqekivlaaqaisrfayqkisngdvilvygcsslvsri
lqeawtegrrfrvvvvdsrpwlegrhtlrslvhagvpasyllipaasyvlpevskvllga
hallangsvmsrvgtaqlalvarahnvpvlvccetykfcervqtdafvsnelddpddlqc
krgehvalanwqnhaslrllnlvydvtppelvdlvitelgmipcssvpvvlrvks

  • Chain 'H':
    Sequence, based on SEQRES records:
    >6ezoH (H:)
maavavavredsgsgmkaelppgpgavgremtkeeklqlrkekkqqkkkrkeekgaepet
gsavsaaqcqvgptrelpesgiqlgtprekvpagrskaelraerrakqeaeralkqarkg
eqggpppkaspstagetpsgvkrlpeypqvddlllrrlvkkperqqvptrkdygskvslf
shlpqysrqnsltqfmsipssvihpamvrlglqysqglvsgsnarciallralqqviqdy
ttppneelsrdlvnklkpymsfltqcrplsasmhnaikflnkeitsvgsskreeeaksel
raaidryvqekivlaaqaisrfayqkisngdvilvygcsslvsrilqeawtegrrfrvvv
vdsrpwlegrhtlrslvhagvpasyllipaasyvlpevskvllgahallangsvmsrvgt
aqlalvarahnvpvlvccetykfcervqtdafvsnelddpddlqckrgehvalanwqnha
slrllnlvydvtppelvdlvitelgmipcssvpvvlrvkssdq

    Sequence, based on observed residues (ATOM records):
    >6ezoH (H:)
qvptrkdygskvslfshlpqysrqnsltqfmsipssvihpamvrlglqysqglvsgsnar
ciallralqqviqdyttppneelsrdlvnklkpymsfltqcrplsasmhnaikflnkeit
svgsskreeeakselraaidryvqekivlaaqaisrfayqkisngdvilvygcsslvsri
lqeawtegrrfrvvvvdsrpwlegrhtlrslvhagvpasyllipaasyvlpevskvllga
hallangsvmsrvgtaqlalvarahnvpvlvccetykfcervqtdafvsnelddpddlqc
krgehvalanwqnhaslrllnlvydvtppelvdlvitelgmipcssvpvvlrv

  • Chain 'I':
    Sequence, based on SEQRES records:
    >6ezoI (I:)
maapvvappgvvvsrankrsgagpggsggggargaeeepppplqavlvadsfdrrffpis
kdqprvllplanvalidytlefltatgvqetfvfccwkaaqikehllkskwcrptslnvv
riitselyrslgdvlrdvdakalvrsdfllvygdvisninitraleehrlrrkleknvsv
mtmifkesspshptrchednvvvavdsttnrvlhfqktqglrrfafplslfqgssdgvev
rydlldchisicspqvaqlftdnfdyqtrddfvrgllvneeilgnqihmhvtakeygarv
snlhmysavcadvirrwvypltpeanftdsttqscthsrhniyrgpevslghgsileenv
llgsgtvigsncfitnsvigpgchigdnvvldqtylwqgvrvaagaqihqsllcdnaevk
ervtlkprsvltsqvvvgpnitlpegsvislhppdaeededdgefsddsgadqekdkvkm
kgynpaevgaagkgylwkaagmnmeeeeelqqnlwglkinmeeeseseseqsmdseepds
rggspqmddikvfqnevlgtlqrgkeeniscdnlvleinslkyaynislkevmqvlshvv
lefplqqmdspldssrycalllpllkawspvfrnyikraadhlealaaiedfflehealg
ismakvlmafyqleilaeetilswfsqrdttdkgqqlrknqqlqrfiqwlkeaeeessed
d

    Sequence, based on observed residues (ATOM records):
    >6ezoI (I:)
epppplqavlpiskdqprvllplanvalidytlefltatgvqetfvfccwkaaqikehll
kskwcrptslnvvriitselyrslgdvlrdvdakalvrsdfllvygdvisninitralee
hrlrrkleknvsvmtmifkesspshptrchednvvvavdsttnrvlhfqktqglrrfafp
lslfqgssdgvevrydlldchisicspqvaqlftdnfdyqtrddfvrgllvneeilgnqi
hmhvtakeygarvsnlhmysavcadvirrwvypltpeanscthsrhniyrgpevslghgs
ileenvllgsgtvigsncfitnsvigpgchigdnvvldqtylwqgvrvaagaqihqsllc
dnaevkervtlkprsvltsqvvvgpnitlpegsvis

  • Chain 'J':
    Sequence, based on SEQRES records:
    >6ezoJ (J:)
maapvvappgvvvsrankrsgagpggsggggargaeeepppplqavlvadsfdrrffpis
kdqprvllplanvalidytlefltatgvqetfvfccwkaaqikehllkskwcrptslnvv
riitselyrslgdvlrdvdakalvrsdfllvygdvisninitraleehrlrrkleknvsv
mtmifkesspshptrchednvvvavdsttnrvlhfqktqglrrfafplslfqgssdgvev
rydlldchisicspqvaqlftdnfdyqtrddfvrgllvneeilgnqihmhvtakeygarv
snlhmysavcadvirrwvypltpeanftdsttqscthsrhniyrgpevslghgsileenv
llgsgtvigsncfitnsvigpgchigdnvvldqtylwqgvrvaagaqihqsllcdnaevk
ervtlkprsvltsqvvvgpnitlpegsvislhppdaeededdgefsddsgadqekdkvkm
kgynpaevgaagkgylwkaagmnmeeeeelqqnlwglkinmeeeseseseqsmdseepds
rggspqmddikvfqnevlgtlqrgkeeniscdnlvleinslkyaynislkevmqvlshvv
lefplqqmdspldssrycalllpllkawspvfrnyikraadhlealaaiedfflehealg
ismakvlmafyqleilaeetilswfsqrdttdkgqqlrknqqlqrfiqwlkeaeeessed
d

    Sequence, based on observed residues (ATOM records):
    >6ezoJ (J:)
ppplqavlpiskdqprvllplanvalidytlefltatgvqetfvfccwkaaqikehllks
kwcrptslnvvriitselyrslgdvlrdvdakalvrsdfllvygdvisninitraleehr
lrrkleknvsvmtmifkesspshptrchednvvvavdsttnrvlhfqktqglrrfafpls
lfqgssdgvevrydlldchisicspqvaqlftdnfdyqtrddfvrgllvneeilgnqihm
hvtakeygarvsnlhmysavcadvirrwvypltpeanscthsrhniyrgpevslghgsil
eenvllgsgtvigsncfitnsvigpgchigdnvvldqtylwqgvrvaagaqihqsllcdn
aevkervtlkprsvltsqvvvgpnitlpegsvis