PDB entry 6ez8

View 6ez8 on RCSB PDB site
Description: human huntingtin-hap40 complex structure
Deposited on 2017-11-14, released 2018-02-21
The last revision was dated 2019-12-11, with a file datestamp of 2019-12-06.
Experiment type: EM
Resolution: 4 Å
R-factor: N/A
AEROSPACI score: 0.07 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Huntingtin
    Species: Homo sapiens [TaxId:9606]
    Gene: HTT, HD, IT15
    Database cross-references and differences (RAF-indexed):
    • Uniprot P42858
      • conflict (1233)
      • conflict (2304)
  • Chain 'B':
    Compound: Factor VIII intron 22 protein
    Species: Homo sapiens [TaxId:9606]
    Gene: F8A1, F8A, F8A2, F8A, F8A3, F8A
    Database cross-references and differences (RAF-indexed):

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6ez8A (A:)
    matleklmkafeslksfqqqqqqqqqqqqqqqqqpppppppppppqlpqpppqaqpllpq
    pqppppppppppgpavaeeplhrpkkelsatkkdrvnhclticenivaqsvrnspefqkl
    lgiamelfllcsddaesdvrmvadeclnkvikalmdsnlprlqlelykeikkngaprslr
    aalwrfaelahlvrpqkcrpylvnllpcltrtskrpeesvqetlaaavpkimasfgnfan
    dneikvllkafianlksssptirrtaagsavsicqhsrrtqyfyswllnvllgllvpved
    ehstllilgvlltlrylvpllqqqvkdtslkgsfgvtrkemevspsaeqlvqvyeltlhh
    tqhqdhnvvtgalellqqlfrtpppellqtltavggigqltaakeesggrsrsgsiveli
    agggsscspvlsrkqkgkvllgeeealeddsesrsdvsssaltasvkdeisgelaassgv
    stpgsaghdiiteqprsqhtlqadsvdlascdltssatdgdeedilshsssqvsavpsdp
    amdlndgtqasspisdssqtttegpdsavtpsdsseivldgtdnqylglqigqpqdedee
    atgilpdeaseafrnssmalqqahllknmshcrqpsdssvdkfvlrdeatepgdqenkpc
    rikgdigqstdddsaplvhcvrllsasflltggknvlvpdrdvrvsvkalalscvgaava
    lhpesffsklykvpldtteypeeqyvsdilnyidhgdpqvrgatailcgtlicsilsrsr
    fhvgdwmgtirtltgntfsladcipllrktlkdessvtcklactavrncvmslcsssyse
    lglqliidvltlrnssywlvrtelletlaeidfrlvsfleakaenlhrgahhytgllklq
    ervlnnvvihllgdedprvrhvaaaslirlvpklfykcdqgqadpvvavardqssvylkl
    lmhetqppshfsvstitriyrgynllpsitdvtmennlsrviaavshelitsttraltfg
    ccealcllstafpvciwslgwhcgvpplsasdesrksctvgmatmiltllssawfpldls
    ahqdalilagnllaasapkslrsswaseeeanpaatkqeevwpalgdralvpmveqlfsh
    llkvinicahvlddvapgpaikaalpsltnppslspirrkgkekepgeqasvplspkkgs
    easaasrqsdtsgpvttskssslgsfyhlpsylrlhdvlkathanykvtldlqnstekfg
    gflrsaldvlsqilelatlqdigkcveeilgylkscfsrepmmatvcvqqllktlfgtnl
    asqfdglssnpsksqgraqrlgsssvrpglyhycfmapythftqaladaslrnmvqaeqe
    ndtsgwfdvlqkvstqlktnltsvtknradknaihnhirlfeplvikalkqyttttcvql
    qkqvldllaqlvqlrvnyclldsdqvfigfvlkqfeyievgqfreseaiipniffflvll
    syeryhskqiigipkiiqlcdgimasgrkavthaipalqpivhdlfvlrgtnkadagkel
    etqkevvvsmllrliqyhqvlemfilvlqqchkenedkwkrlsrqiadiilpmlakqqmh
    idshealgvlntlfeilapsslrpvdmllrsmfvtpntmasvstvqlwisgilailrvli
    sqstedivlsriqelsfspylisctvinrlrdgdsnstleehsegkqiknlpeetfsrfl
    lqlvgilledivtkqlkvemseqqhtfycqelgtllmclihifksgmfrritaaatrlfr
    sdgcggsfytldslnlrarsmitthpalvllwcqilllvnhtdyrwwaevqqtpkrhsls
    stkllspqmsgeeedsdlaaklgmcnreivrrgalilfcdyvcqnlhdsehltwlivnhi
    qdlislsheppvqdfisavhrnsaasglfiqaiqsrcenlstptmlkktlqclegihlsq
    sgavltlyvdrllctpfrvlarmvdilacrrvemllaanlqssmaqlpmeelnriqeylq
    ssglaqrhqrlyslldrfrlstmqdslspsppvsshpldgdghvsletvspdkdwyvhlv
    ksqcwtrsdsallegaelvnripaedmnafmmnsefnlsllapclslgmseisggqksal
    feaarevtlarvsgtvqqlpavhhvfqpelpaepaaywsklndlfgdaalyqslptlara
    laqylvvvsklpshlhlppekekdivkfvvatlealswhliheqiplsldlqagldcccl
    alqlpglwsvvsstefvthacslihcvhfileavavqpgeqllsperrtntpkaiseeee
    evdpntqnpkyitaacemvaemveslqsvlalghkrnsgvpafltpllrniiislarlpl
    vnsytrvpplvwklgwspkpggdfgtafpeipveflqekevfkefiyrintlgwtsrtqf
    eetwatllgvlvtqplvmeqeesppeedtertqinvlavqaitslvlsamtvpvagnpav
    scleqqprnkplkaldtrfgrklsiirgiveqeiqamvskreniathhlyqawdpvpsls
    pattgalisheklllqinperelgsmsyklgqvsihsvwlgnsitplreeewdeeeeeea
    dapapsspptspvnsrkhragvdihscsqfllelysrwilpsssarrtpailisevvrsl
    lvvsdlfternqfelmyvtltelrrvhpsedeilaqylvpatckaaavlgmdkavaepvs
    rllestlrsshlpsrvgalhgvlyvlecdllddtakqlipvisdyllsnlkgiahcvnih
    sqqhvlvmcatafylienypldvgpefsasiiqmcgvmlsgseestpsiiyhcalrgler
    lllseqlsrldaeslvklsvdrvnvhsphramaalglmltcmytgkekvspgrtsdpnpa
    apdsesvivamervsvlfdrirkgfpcearvvarilpqflddffppqdimnkvigeflsn
    qqpypqfmatvvykvfqtlhstgqssmvrdwvmlslsnftqrapvamatwslscffvsas
    tspwvaailphvisrmgkleqvdvnlfclvatdfyrhqieeeldrrafqsvlevvaapgs
    pyhrlltclrnvhkvttc
    

    Sequence, based on observed residues (ATOM records):
    >6ez8A (A:)
    tkkdrvnhclticenivaqsvrnspefqkllgiamelfllcsddaesdvrmvadeclnkv
    ikalmdsnlprlqlelykeikkngaprslraalwrfaelahlvrpqkcrpylvnllpclt
    rtskrpeesvqetlaaavpkimasfgnfandneikvllkafianlksssptirrtaagsa
    vsicqhsrrtqyfyswllnvllgllvpvedehstllilgvlltlrylvpllqvspsaeql
    vqvyeltlhhtqhqdhnvvtgalellqqlfrtpppellqtltavggigqltarikgdigq
    stdddsaplvhcvrllsasflltggknvlvpdrdvrvsvkalalscvgaavalhpesffs
    klykvpldtteypeeqyvsdilnyidhgdpqvrgatailcgtlicsilsrsrfhvgdwmg
    tirtltgntfsladcipllrktlkdessvtcklactavrncvmslcsssyselglqliid
    vltlrnssywlvrtelletlaeidfrlvsfleakaenlhrgahhytgllklqervlnnvv
    ihllgdedprvrhvaaaslirlvpklfykcdqgqadpvvavardqssvylkriyrgynll
    psitdvtmennlsrviaavshelitsttraltfgccealcllstafpvciwslgwhcgvp
    plctvgmatmiltllssawfpldlsahqdalilagnllaasapkslrvwpalgdralvpm
    veqlfshllkvinicahvlddvaplgsfyhlpsylrlhdvlkathanykvtldlqnstek
    fggflrsaldvlsqilelatlqdigkcveeilgylkscfsrepmmatvcvqqllktlfgt
    pglyhycfmapythftqaladaslrlfeplvikalkqyttttcvqlqkqvldllaqlvql
    rvnyclldsdqvfigfvlkqfeyievgqfreseaiipniffflvllsyeigipkiiqlcd
    gimasgrkavthaipalqpivhdlfvlgkeletqkevvvsmllrliqyhqvlemfilvlq
    qchkenedkwkrlsrqiadiilpmlakqqmhidshealgvlntlfeilapsslrpvdmll
    rsmfvtpntmasvstvqlwisgilailrvlisqstedivlsriqelsfspylisctvinr
    lrdgknlpeetfsrfllqlvgilledivtkqlkvemseqqhtfycqelgtllmclihifk
    sgmfrritaaatrlfrsdgcggsfytldslnlrarsmitthpalvllwcqilllvnhtdy
    rwwaevqqtplgmcnreivrrgalilfcdyvcqnlhdsehltwlivnhiqdlislshepp
    vqdfisavhrnsaasglfiqaiqsrcenlstptmlkktlqclegihlsqsgavltlyvdr
    llctpfrvlarmvdilacrrvemllaanlqssmaqlpmeelnriqeylqssglaqrhqrl
    yslldrfrlstdkdwyvhlvksqcwtrsdsallegaelvnripaedmnafmmnsefnlsl
    lapclslgmseisggqksalfeaarevtlarvsgtvqqlpavhhvfqpelpaepaaywsk
    lndlfgdaalyqslptlaralaqylvvvsklpshlhlppekekdivkfvvatlealswhl
    iheqiplsldlqagldccclalqlpglwsvvsstefvthacslihcvhfileavavqpge
    qllsnpkyitaacemvaemveslqsvlalghkrnsgvpafltpllrniiislarlplvns
    ytrvpplvwklgwspkpggdfgtafpeipveflqekevfkefiyrintlgwtsrtqfeet
    watllgvlrtqinvlavqaitslvlsamtvpvagnpavscleqqprnkplkaldtrfgrk
    lsiirgiveqeiqamvskreniathhlyqawdpvpslttgalisheklllqinperelgs
    msyklgqvsihsvwlgnsitpgvdihscsqfllelysrwiltpailisevvrsllvvsdl
    fternqfelmyvtltelrrvhpsedeilaqylvpatckaaavlgmdkavaepvsrllest
    lrsshlpsrvgalhgvlyvlecdllddtakqlipvisdyllsnlkgiahcvnihsqqhvl
    vmcatafylienypldvgpefsasiiqmcgvmlsgseestpsiiyhcalrglerlllseq
    lsrldaeslvklsvdrvnvhsphramaalglmltcmytgesvivamervsvlfdrirkgf
    pcearvvarilpqflddffppqdimnkvigeflsnqqpypqfmatvvykvfqtlhstgqs
    smvrdwvmlslsnftqrapvamatwslscffvsastspwvaailphvisrmgkleqvdvn
    lfclvatdfyrhq
    

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6ez8B (B:)
    maaaaaglggggagpgpeagdflaryrlvsnklkkrflrkpnvaeageqfgqlgrelraq
    eclpyaawcqlavarcqqalfhgpgealalteaarlflrqerdarqrlvcpaaygeplqa
    aasalgaavrlhlelgqpaaaaalclelaaalrdlgqpaaaaghfqraaqlqlpqlplaa
    lqalgeaascqllardytgalavftrmqrlarehgshpvqslppppppapqpgpgatpal
    paallppnsgsaapspaalgafsdvlvrcevsrvllllllqpppakllpehaqtlekysw
    eafdshgqessgqlpeelflllqslvmathekdteaikslqvemwplltaeqnhllhlvl
    qetispsgqgv
    

    Sequence, based on observed residues (ATOM records):
    >6ez8B (B:)
    nvaeageqfgqlgrelraqeclpyaawcqlavarcqqalfhgpgealalteaarlflrqe
    rdarqrlvcpaaygeplqaaasalgaavrlhlelgqpaaaaalclelaaalrdlgqpaaa
    aghfqraaqlqlpqlplaalqalgeaascqllardytgalavftrmqrlarehgsalgaf
    sdvlvrcevsrvllllllqpppakllpehaqtlekyslpeelflllqslvmathekdtea
    ikslqvemwplltaeqnhllhlvlqeti