PDB entry 6ez2

View 6ez2 on RCSB PDB site
Description: Human butyrylcholinesterase carbamylated.
Class: hydrolase
Keywords: Butyrylcholinesterase, rivastigmine analogues, Alzheimer disease, central nervous system, inhibitor., HYDROLASE
Deposited on 2017-11-14, released 2018-12-12
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-06-29.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: N/A
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cholinesterase
    Species: Homo sapiens [TaxId:9606]
    Gene: BCHE, CHE1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P06276 (0-526)
      • conflict (195)
    Domains in SCOPe 2.08: d6ez2a_
  • Chain 'B':
    Compound: cholinesterase
    Species: Homo sapiens [TaxId:9606]
    Gene: BCHE, CHE1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P06276 (Start-526)
      • conflict (195)
    Domains in SCOPe 2.08: d6ez2b_
  • Heterogens: NAG, GOL, CL, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6ez2A (A:)
diiiatkngkvrgmnltvfggtvtaflgipyaqpplgrlrfkkpqsltkwsdiwnatkya
nsccqnidqsfpgfhgsemwnpntdlsedclylnvwipapkpknatvliwiygggfqtgt
sslhvydgkflarvervivvsmnyrvgalgflalpgnpeapgnmglfdqqlalqwvqkni
aafggnpksvtlfgexagaasvslhllspgshslftrailqsgsfnapwavtslyearnr
tlnlakltgcsreneteiikclrnkdpqeillneafvvpygtplsvnfgptvdgdfltdm
pdillelgqfkktqilvgvnkdegtaflvygapgfskdnnsiitrkefqeglkiffpgvs
efgkesilfhytdwvddqrpenyrealgdvvgdynficpaleftkkfsewgnnaffyyfe
hrssklpwpewmgvmhgyeiefvfglplerrdnytkaeeilsrsivkrwanfakygnpne
tqnnstswpvfksteqkyltlntestrimtklraqqcrfwtsffpkv

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6ez2B (B:)
diiiatkngkvrgmnltvfggtvtaflgipyaqpplgrlrfkkpqsltkwsdiwnatkya
nsccqnidqsfpgfhgsemwnpntdlsedclylnvwipapkpknatvliwiygggfqtgt
sslhvydgkflarvervivvsmnyrvgalgflalpgnpeapgnmglfdqqlalqwvqkni
aafggnpksvtlfgexagaasvslhllspgshslftrailqsgsfnapwavtslyearnr
tlnlakltgcsreneteiikclrnkdpqeillneafvvpygtplsvnfgptvdgdfltdm
pdillelgqfkktqilvgvnkdegtaflvygapgfskdnnsiitrkefqeglkiffpgvs
efgkesilfhytdwvddqrpenyrealgdvvgdynficpaleftkkfsewgnnaffyyfe
hrssklpwpewmgvmhgyeiefvfglplerrdnytkaeeilsrsivkrwanfakygnpne
tqnnstswpvfksteqkyltlntestrimtklraqqcrfwtsffpkv

    Sequence, based on observed residues (ATOM records): (download) 
    >6ez2B (B:)
iiiatkngkvrgmnltvfggtvtaflgipyaqpplgrlrfkkpqsltkwdiwnatkyans
ccqnidqsfpgfhgsemwnpntdlsedclylnvwipapkpknatvliwiygggfqtgtss
lhvydgkflarvervivvsmnyrvgalgflalpgnpeapgnmglfdqqlalqwvqkniaa
fggnpksvtlfgexagaasvslhllspgshslftrailqsgsfnapwavtslyearnrtl
nlakltgcsreneteiikclrnkdpqeillneafvvpygtplsvnfgptvdgdfltdmpd
illelgqfkktqilvgvnkdegtaflvygapgfskdnnsiitrkefqeglkiffpgvsef
gkesilfhytdwvddqrpenyrealgdvvgdynficpaleftkkfsewgnnaffyyfehr
ssklpwpewmgvmhgyeiefvfglplerrdnytkaeeilsrsivkrwanfakygnpnetq
nnstswpvfksteqkyltlntestrimtklraqqcrfwtsffpkv