PDB entry 6ewb

View 6ewb on RCSB PDB site
Description: Crystal structure of GII.4 UNSW 2012 P domain in complex with Fab 10E9
Class: viral protein
Keywords: protein-Fab complex, Fab fragment of IgG, norovirus, antibody, VIRAL PROTEIN
Deposited on 2017-11-03, released 2018-11-14
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-05-29, with a file datestamp of 2019-05-24.
Experiment type: XRAY
Resolution: 2.78 Å
R-factor: N/A
AEROSPACI score: 0.17 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: vp1
    Species: Norovirus Hu/GII.4/Sydney/NSW0514/2012/AU [TaxId:1241973]
    Database cross-references and differences (RAF-indexed):
    • Uniprot K4LM89 (4-309)
      • expression tag (3)
    Domains in SCOPe 2.08: d6ewba1, d6ewba2
  • Chain 'B':
    Compound: vp1
    Species: Norovirus Hu/GII.4/Sydney/NSW0514/2012/AU [TaxId:1241973]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6ewbb_
  • Chain 'C':
    Compound: vp1
    Species: Norovirus Hu/GII.4/Sydney/NSW0514/2012/AU [TaxId:1241973]
    Database cross-references and differences (RAF-indexed):
    • Uniprot K4LM89 (4-309)
      • expression tag (0-3)
    Domains in SCOPe 2.08: d6ewbc1, d6ewbc2
  • Chain 'D':
    Compound: vp1
    Species: Norovirus Hu/GII.4/Sydney/NSW0514/2012/AU [TaxId:1241973]
    Database cross-references and differences (RAF-indexed):
    • Uniprot K4LM89 (4-309)
      • expression tag (1-3)
    Domains in SCOPe 2.08: d6ewbd1, d6ewbd2
  • Chain 'E':
    Compound: Fab heavy chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 6EWB (0-End)
    Domains in SCOPe 2.08: d6ewbe1, d6ewbe2
  • Chain 'F':
    Compound: Fab light chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 6EWB
    Domains in SCOPe 2.08: d6ewbf1, d6ewbf2
  • Chain 'G':
    Compound: Fab heavy chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 6EWB (0-215)
    Domains in SCOPe 2.08: d6ewbg1, d6ewbg2
  • Chain 'H':
    Compound: Fab heavy chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 6EWB (0-215)
    Domains in SCOPe 2.08: d6ewbh1, d6ewbh2
  • Chain 'I':
    Compound: Fab light chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 6EWB (0-End)
    Domains in SCOPe 2.08: d6ewbi1, d6ewbi2
  • Chain 'J':
    Compound: Fab heavy chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 6EWB (0-End)
    Domains in SCOPe 2.08: d6ewbj1, d6ewbj2
  • Chain 'K':
    Compound: Fab light chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 6EWB (0-End)
    Domains in SCOPe 2.08: d6ewbk1, d6ewbk2
  • Chain 'L':
    Compound: Fab light chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 6EWB
    Domains in SCOPe 2.08: d6ewbl1, d6ewbl2
  • Heterogens: EDO

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6ewbA (A:)
gpgskpfsvpvltveemtnsrfpipleklftgpssafvvqpqngrcttdgvllgttqlsp
vnictfrgdvthitgsrnytmnlasqnwndydpteeipaplgtpdfvgkiqgvltqttrt
dgstrghkatvytgsadfapklgrvqfetdtdrdfeanqntkftpvgviqdggtthrnep
qqwvlpsysgrnthnvhlapavaptfpgeqllffrstmpgcsgypnmdldcllpqewvqy
fyqeaapaqsdvallrfvnpdtgrvlfecklhksgyvtvahtgqhdlvippngyfrfdsw
vnqfytlapm

    Sequence, based on observed residues (ATOM records): (download) 
    >6ewbA (A:)
skpfsvpvltveemtnsrfpipleklftgpssafvvqpqngrcttdgvllgttqlspvni
ctfrgdvthitgsrnytmnlasqnwndydpteeipaplgtpdfvgkiqgvltqttrtdgs
trghkatvytgsadfapklgrvqfetdtdrdfeanqntkftpvgviqdggtthrnepqqw
vlpsysgrnthnvhlapavaptfpgeqllffrstmpgcsgypnmdldcllpqewvqyfyq
eaapaqsdvallrfvnpdtgrvlfecklhksgyvtvahtgqhdlvippngyfrfdswvnq
fytlapm

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6ewbB (B:)
gpgskpfsvpvltveemtnsrfpipleklftgpssafvvqpqngrcttdgvllgttqlsp
vnictfrgdvthitgsrnytmnlasqnwndydpteeipaplgtpdfvgkiqgvltqttrt
dgstrghkatvytgsadfapklgrvqfetdtdrdfeanqntkftpvgviqdggtthrnep
qqwvlpsysgrnthnvhlapavaptfpgeqllffrstmpgcsgypnmdldcllpqewvqy
fyqeaapaqsdvallrfvnpdtgrvlfecklhksgyvtvahtgqhdlvippngyfrfdsw
vnqfytlapm

    Sequence, based on observed residues (ATOM records): (download) 
    >6ewbB (B:)
kpfsvpvltveemtnsrfpipleklftgpssafvvqpqngrcttdgvllgttqlspvnic
tfrgdvthitgsrnytmnlasqnwndydpteeipaplgtpdfvgkiqgvltqttrtdgst
rghkatvytgsadfapklgrvqfetdtdrdfeanqntkftpvgviqdggtthrnepqqwv
lpsysgrnthnvhlapavaptfpgeqllffrstmpgcsgypnmdldcllpqewvqyfyqe
aapaqsdvallrfvnpdtgrvlfecklhksgyvtvahtgqhdlvippngyfrfdswvnqf
ytlapm

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6ewbC (C:)
gpgskpfsvpvltveemtnsrfpipleklftgpssafvvqpqngrcttdgvllgttqlsp
vnictfrgdvthitgsrnytmnlasqnwndydpteeipaplgtpdfvgkiqgvltqttrt
dgstrghkatvytgsadfapklgrvqfetdtdrdfeanqntkftpvgviqdggtthrnep
qqwvlpsysgrnthnvhlapavaptfpgeqllffrstmpgcsgypnmdldcllpqewvqy
fyqeaapaqsdvallrfvnpdtgrvlfecklhksgyvtvahtgqhdlvippngyfrfdsw
vnqfytlapm

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6ewbD (D:)
gpgskpfsvpvltveemtnsrfpipleklftgpssafvvqpqngrcttdgvllgttqlsp
vnictfrgdvthitgsrnytmnlasqnwndydpteeipaplgtpdfvgkiqgvltqttrt
dgstrghkatvytgsadfapklgrvqfetdtdrdfeanqntkftpvgviqdggtthrnep
qqwvlpsysgrnthnvhlapavaptfpgeqllffrstmpgcsgypnmdldcllpqewvqy
fyqeaapaqsdvallrfvnpdtgrvlfecklhksgyvtvahtgqhdlvippngyfrfdsw
vnqfytlapm

    Sequence, based on observed residues (ATOM records): (download) 
    >6ewbD (D:)
pgskpfsvpvltveemtnsrfpipleklftgpssafvvqpqngrcttdgvllgttqlspv
nictfrgdvthitgsrnytmnlasqnwndydpteeipaplgtpdfvgkiqgvltqttrtd
gstrghkatvytgsadfapklgrvqfetdtdrdfeanqntkftpvgviqdggtthrnepq
qwvlpsysgrnthnvhlapavaptfpgeqllffrstmpgcsgypnmdldcllpqewvqyf
yqeaapaqsdvallrfvnpdtgrvlfecklhksgyvtvahtgqhdlvippngyfrfdswv
nqfytlapm

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >6ewbE (E:)
qvqlqqsgaelmkpgasvkisctatgytfitywiqwvkqrpghglewigetlpgsgstny
nekfkgkatftadtssntaymqlssltsedsaiyycarigrsndywgqgttltvssaktt
ppsvyplapgsaaqtnsmvtlgclvkgyfpepvtvtwnsgslssgvhtfpavlqsdlytl
sssvtvpsstwpsetvtcnvahpasstkvdkkivpr

    Sequence, based on observed residues (ATOM records): (download) 
    >6ewbE (E:)
qvqlqqsgaelmkpgasvkisctatgytfitywiqwvkqrpghglewigetlpgsgstny
nekfkgkatftadtssntaymqlssltsedsaiyycarigrsndywgqgttltvssaktt
ppsvyplapmvtlgclvkgyfpepvtvtwslssgvhtfpavlqsdlytlsssvtvtvtcn
vahpasstkvdkkiv

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >6ewbF (F:)
gqivltqsptimsaspgekvtmtcsasssvdymhwyqqksgtspkrwiydtyklasgvpa
rfsgsgsgtsysltinsmeaedaatyycqqwssnpltfgagtklelkradaaptvsifpp
sseqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysmsstlt
ltkdeyerhnsytceathktstspivksfnrnec

    Sequence, based on observed residues (ATOM records): (download) 
    >6ewbF (F:)
qivltqsptimsaspgekvtmtcsasssvdymhwyqqksgtspkrwiydtyklasgvpar
fsgsgsgtsysltinsmeaedaatyycqqwssnpltfgagtklelkradaaptvsifpps
seqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysmsstltl
tkdeyerhnsytceathktstspivksfn

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >6ewbG (G:)
qvqlqqsgaelmkpgasvkisctatgytfitywiqwvkqrpghglewigetlpgsgstny
nekfkgkatftadtssntaymqlssltsedsaiyycarigrsndywgqgttltvssaktt
ppsvyplapgsaaqtnsmvtlgclvkgyfpepvtvtwnsgslssgvhtfpavlqsdlytl
sssvtvpsstwpsetvtcnvahpasstkvdkkivpr

    Sequence, based on observed residues (ATOM records): (download) 
    >6ewbG (G:)
qvqlqqsgaelmkpgasvkisctatgytfitywiqwvkqrpghglewigetlpgsgstny
nekfkgkatftadtssntaymqlssltsedsaiyycarigrsndywgqgttltvssaktt
ppsvyplapgnsmvtlgclvkgyfpepvtvtwnsgslssgvhtfpavlqsdlytlsssvt
vpsstwpsetvtcnvahpasstkvdkkivpr

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >6ewbH (H:)
qvqlqqsgaelmkpgasvkisctatgytfitywiqwvkqrpghglewigetlpgsgstny
nekfkgkatftadtssntaymqlssltsedsaiyycarigrsndywgqgttltvssaktt
ppsvyplapgsaaqtnsmvtlgclvkgyfpepvtvtwnsgslssgvhtfpavlqsdlytl
sssvtvpsstwpsetvtcnvahpasstkvdkkivpr

    Sequence, based on observed residues (ATOM records): (download) 
    >6ewbH (H:)
qvqlqqsgaelmkpgasvkisctatgytfitywiqwvkqrpghglewigetlpgsgstny
nekfkgkatftadtssntaymqlssltsedsaiyycarigrsndywgqgttltvssaktt
ppsvyplapgsmvtlgclvkgyfpepvtvtwnsgslssgvhtfpavlqsdlytlsssvtv
psstwpsetvtcnvahpasstkvdkkivpr

  • Chain 'I':
    Sequence, based on SEQRES records: (download) 
    >6ewbI (I:)
gqivltqsptimsaspgekvtmtcsasssvdymhwyqqksgtspkrwiydtyklasgvpa
rfsgsgsgtsysltinsmeaedaatyycqqwssnpltfgagtklelkradaaptvsifpp
sseqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysmsstlt
ltkdeyerhnsytceathktstspivksfnrnec

    Sequence, based on observed residues (ATOM records): (download) 
    >6ewbI (I:)
gqivltqsptimsaspgekvtmtcsasssvdymhwyqqksgtspkrwiydtyklasgvpa
rfsgsgsgtsysltinsmeaedaatyycqqwssnpltfgagtklelkradaaptvsifpp
sseqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysmsstlt
ltkdeyerhnsytceathktstspivksfnr

  • Chain 'J':
    Sequence, based on SEQRES records: (download) 
    >6ewbJ (J:)
qvqlqqsgaelmkpgasvkisctatgytfitywiqwvkqrpghglewigetlpgsgstny
nekfkgkatftadtssntaymqlssltsedsaiyycarigrsndywgqgttltvssaktt
ppsvyplapgsaaqtnsmvtlgclvkgyfpepvtvtwnsgslssgvhtfpavlqsdlytl
sssvtvpsstwpsetvtcnvahpasstkvdkkivpr

    Sequence, based on observed residues (ATOM records): (download) 
    >6ewbJ (J:)
qvqlqqsgaelmkpgasvkisctatgytfitywiqwvkqrpghglewigetlpgsgstny
nekfkgkatftadtssntaymqlssltsedsaiyycarigrsndywgqgttltvssaktt
ppsvyplapsmvtlgclvkgyfpepvtvtwnsgslssgvhtfpavlqsdlytlsssvtvp
stwpsetvtcnvahpasstkvdkkivp

  • Chain 'K':
    Sequence, based on SEQRES records: (download) 
    >6ewbK (K:)
gqivltqsptimsaspgekvtmtcsasssvdymhwyqqksgtspkrwiydtyklasgvpa
rfsgsgsgtsysltinsmeaedaatyycqqwssnpltfgagtklelkradaaptvsifpp
sseqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysmsstlt
ltkdeyerhnsytceathktstspivksfnrnec

    Sequence, based on observed residues (ATOM records): (download) 
    >6ewbK (K:)
gqivltqsptimsaspgekvtmtcsasssvdymhwyqqksgtspkrwiydtyklasgvpa
rfsgsgsgtsysltinsmeaedaatyycqqwssnpltfgagtklelkradaaptvsifpp
sseqltsggasvvcflnnfypkdinvkwkidgngvlnswtdqdskdstysmsstltltky
erhnsytceathktstspivksfnr

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >6ewbL (L:)
gqivltqsptimsaspgekvtmtcsasssvdymhwyqqksgtspkrwiydtyklasgvpa
rfsgsgsgtsysltinsmeaedaatyycqqwssnpltfgagtklelkradaaptvsifpp
sseqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysmsstlt
ltkdeyerhnsytceathktstspivksfnrnec

    Sequence, based on observed residues (ATOM records): (download) 
    >6ewbL (L:)
qivltqsptimsaspgekvtmtcsasssvdymhwyqqksgtspkrwiydtyklasgvpar
fsgsgsgtsysltinsmeaedaatyycqqwssnpltfgagtklelkradaaptvsifpps
seqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysmsstltl
tkdeyerhnsytceathktstspivksfnr