PDB entry 6ew0

View 6ew0 on RCSB PDB site
Description: cryo-em structure of gdp-microtubule co-polymerised with doublecortin and supplemented with taxol
Deposited on 2017-11-03, released 2018-07-04
The last revision was dated 2019-12-11, with a file datestamp of 2019-12-06.
Experiment type: EM
Resolution: 3.8 Å
R-factor: N/A
AEROSPACI score: 0.08 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tubulin alpha-1B chain
    Species: Sus scrofa [TaxId:9823]
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Tubulin beta chain
    Species: Sus scrofa [TaxId:9823]
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Tubulin alpha-1B chain
    Species: Sus scrofa [TaxId:9823]
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: Tubulin beta chain
    Species: Sus scrofa [TaxId:9823]
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: Tubulin alpha-1B chain
    Species: Sus scrofa [TaxId:9823]
    Database cross-references and differences (RAF-indexed):
  • Chain 'F':
    Compound: Tubulin beta chain
    Species: Sus scrofa [TaxId:9823]
    Database cross-references and differences (RAF-indexed):
  • Chain 'G':
    Compound: Tubulin beta chain
    Species: Sus scrofa [TaxId:9823]
    Database cross-references and differences (RAF-indexed):
  • Chain 'H':
    Compound: Tubulin beta chain
    Species: Sus scrofa [TaxId:9823]
    Database cross-references and differences (RAF-indexed):
  • Chain 'I':
    Compound: Tubulin beta chain
    Species: Sus scrofa [TaxId:9823]
    Database cross-references and differences (RAF-indexed):
  • Chain 'J':
    Compound: Tubulin alpha-1B chain
    Species: Sus scrofa [TaxId:9823]
    Database cross-references and differences (RAF-indexed):
  • Chain 'K':
    Compound: Tubulin alpha-1B chain
    Species: Sus scrofa [TaxId:9823]
    Database cross-references and differences (RAF-indexed):
  • Chain 'L':
    Compound: Tubulin alpha-1B chain
    Species: Sus scrofa [TaxId:9823]
    Database cross-references and differences (RAF-indexed):
  • Heterogens: GTP, MG, GDP, TA1

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6ew0A (A:)
mrecisihvgqagvqignacwelyclehgiqpdgqmpsdktigggddsfntffsetgagk
hvpravfvdleptvidevrtgtyrqlfhpeqlitgkedaannyarghytigkeiidlvld
rirkladqctglqgflvfhsfgggtgsgftsllmerlsvdygkksklefsiypapqvsta
vvepynsiltthttlehsdcafmvdneaiydicrrnldierptytnlnrlisqivssita
slrfdgalnvdltefqtnlvpyprihfplatyapvisaekayheqlsvaeitnacfepan
qmvkcdprhgkymaccllyrgdvvpkdvnaaiatiktkrsiqfvdwcptgfkvginyqpp
tvvpggdlakvqravcmlsnttaiaeawarldhkfdlmyakrafvhwyvgegmeegefse
aredmaalekdyeevgvdsvegegeeegeey

    Sequence, based on observed residues (ATOM records):
    >6ew0A (A:)
mrecisihvgqagvqignacwelyclehgiqpdgqmpdsfntffsetgagkhvpravfvd
leptvidevrtgtyrqlfhpeqlitgkedaannyarghytigkeiidlvldrirkladqc
tglqgflvfhsfgggtgsgftsllmerlsvdygkksklefsiypapqvstavvepynsil
tthttlehsdcafmvdneaiydicrrnldierptytnlnrlisqivssitaslrfdgaln
vdltefqtnlvpyprihfplatyapvisaekayheqlsvaeitnacfepanqmvkcdprh
gkymaccllyrgdvvpkdvnaaiatiktkrsiqfvdwcptgfkvginyqpptvvpggdla
kvqravcmlsnttaiaeawarldhkfdlmyakrafvhwyvgegmeegefsearedmaale
kdyeevgvdsve

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6ew0B (B:)
mreivhiqagqcgnqigakfwevisdehgidptgsyhgdsdlqlerinvyyneaagnkyv
prailvdlepgtmdsvrsgpfgqifrpdnfvfgqsgagnnwakghytegaelvdsvldvv
rkesescdclqgfqlthslgggtgsgmgtlliskireeypdrimntfsvvpspkvsdtvv
epynatlsvhqlventdetycidnealydicfrtlklttptygdlnhlvsatmsgvttcl
rfpgqlnadlrklavnmvpfprlhffmpgfapltsrgsqqyraltvpeltqqmfdaknmm
aacdprhgryltvaavfrgrmsmkevdeqmlnvqnknssyfvewipnnvktavcdipprg
lkmsatfignstaiqelfkriseqftamfrrkaflhwytgegmdemefteaesnmndlvs
eyqqyqdatadeqgefeeegeedea

    Sequence, based on observed residues (ATOM records):
    >6ew0B (B:)
mreivhiqagqcgnqigakfwevisdehgidptgsyhgdsdlqlerinvyyneaagnkyv
prailvdlepgtmdsvrsgpfgqifrpdnfvfgqsgagnnwakghytegaelvdsvldvv
rkesescdclqgfqlthslgggtgsgmgtlliskireeypdrimntfsvvpspkvsdtvv
epynatlsvhqlventdetycidnealydicfrtlklttptygdlnhlvsatmsgvttcl
rfpgqlnadlrklavnmvpfprlhffmpgfapltsrgsqqyraltvpeltqqmfdaknmm
aacdprhgryltvaavfrgrmsmkevdeqmlnvqnknssyfvewipnnvktavcdipprg
lkmsatfignstaiqelfkriseqftamfrrkaflhwytgegmdemefteaesnmndlvs
eyqqyqdat

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6ew0C (C:)
mrecisihvgqagvqignacwelyclehgiqpdgqmpsdktigggddsfntffsetgagk
hvpravfvdleptvidevrtgtyrqlfhpeqlitgkedaannyarghytigkeiidlvld
rirkladqctglqgflvfhsfgggtgsgftsllmerlsvdygkksklefsiypapqvsta
vvepynsiltthttlehsdcafmvdneaiydicrrnldierptytnlnrlisqivssita
slrfdgalnvdltefqtnlvpyprihfplatyapvisaekayheqlsvaeitnacfepan
qmvkcdprhgkymaccllyrgdvvpkdvnaaiatiktkrsiqfvdwcptgfkvginyqpp
tvvpggdlakvqravcmlsnttaiaeawarldhkfdlmyakrafvhwyvgegmeegefse
aredmaalekdyeevgvdsvegegeeegeey

    Sequence, based on observed residues (ATOM records):
    >6ew0C (C:)
mrecisihvgqagvqignacwelyclehgiqpdgqmpdsfntffsetgagkhvpravfvd
leptvidevrtgtyrqlfhpeqlitgkedaannyarghytigkeiidlvldrirkladqc
tglqgflvfhsfgggtgsgftsllmerlsvdygkksklefsiypapqvstavvepynsil
tthttlehsdcafmvdneaiydicrrnldierptytnlnrlisqivssitaslrfdgaln
vdltefqtnlvpyprihfplatyapvisaekayheqlsvaeitnacfepanqmvkcdprh
gkymaccllyrgdvvpkdvnaaiatiktkrsiqfvdwcptgfkvginyqpptvvpggdla
kvqravcmlsnttaiaeawarldhkfdlmyakrafvhwyvgegmeegefsearedmaale
kdyeevgvdsve

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6ew0D (D:)
mreivhiqagqcgnqigakfwevisdehgidptgsyhgdsdlqlerinvyyneaagnkyv
prailvdlepgtmdsvrsgpfgqifrpdnfvfgqsgagnnwakghytegaelvdsvldvv
rkesescdclqgfqlthslgggtgsgmgtlliskireeypdrimntfsvvpspkvsdtvv
epynatlsvhqlventdetycidnealydicfrtlklttptygdlnhlvsatmsgvttcl
rfpgqlnadlrklavnmvpfprlhffmpgfapltsrgsqqyraltvpeltqqmfdaknmm
aacdprhgryltvaavfrgrmsmkevdeqmlnvqnknssyfvewipnnvktavcdipprg
lkmsatfignstaiqelfkriseqftamfrrkaflhwytgegmdemefteaesnmndlvs
eyqqyqdatadeqgefeeegeedea

    Sequence, based on observed residues (ATOM records):
    >6ew0D (D:)
mreivhiqagqcgnqigakfwevisdehgidptgsyhgdsdlqlerinvyyneaagnkyv
prailvdlepgtmdsvrsgpfgqifrpdnfvfgqsgagnnwakghytegaelvdsvldvv
rkesescdclqgfqlthslgggtgsgmgtlliskireeypdrimntfsvvpspkvsdtvv
epynatlsvhqlventdetycidnealydicfrtlklttptygdlnhlvsatmsgvttcl
rfpgqlnadlrklavnmvpfprlhffmpgfapltsrgsqqyraltvpeltqqmfdaknmm
aacdprhgryltvaavfrgrmsmkevdeqmlnvqnknssyfvewipnnvktavcdipprg
lkmsatfignstaiqelfkriseqftamfrrkaflhwytgegmdemefteaesnmndlvs
eyqqyqdat

  • Chain 'E':
    Sequence, based on SEQRES records:
    >6ew0E (E:)
mrecisihvgqagvqignacwelyclehgiqpdgqmpsdktigggddsfntffsetgagk
hvpravfvdleptvidevrtgtyrqlfhpeqlitgkedaannyarghytigkeiidlvld
rirkladqctglqgflvfhsfgggtgsgftsllmerlsvdygkksklefsiypapqvsta
vvepynsiltthttlehsdcafmvdneaiydicrrnldierptytnlnrlisqivssita
slrfdgalnvdltefqtnlvpyprihfplatyapvisaekayheqlsvaeitnacfepan
qmvkcdprhgkymaccllyrgdvvpkdvnaaiatiktkrsiqfvdwcptgfkvginyqpp
tvvpggdlakvqravcmlsnttaiaeawarldhkfdlmyakrafvhwyvgegmeegefse
aredmaalekdyeevgvdsvegegeeegeey

    Sequence, based on observed residues (ATOM records):
    >6ew0E (E:)
mrecisihvgqagvqignacwelyclehgiqpdgqmpdsfntffsetgagkhvpravfvd
leptvidevrtgtyrqlfhpeqlitgkedaannyarghytigkeiidlvldrirkladqc
tglqgflvfhsfgggtgsgftsllmerlsvdygkksklefsiypapqvstavvepynsil
tthttlehsdcafmvdneaiydicrrnldierptytnlnrlisqivssitaslrfdgaln
vdltefqtnlvpyprihfplatyapvisaekayheqlsvaeitnacfepanqmvkcdprh
gkymaccllyrgdvvpkdvnaaiatiktkrsiqfvdwcptgfkvginyqpptvvpggdla
kvqravcmlsnttaiaeawarldhkfdlmyakrafvhwyvgegmeegefsearedmaale
kdyeevgvdsve

  • Chain 'F':
    Sequence, based on SEQRES records:
    >6ew0F (F:)
mreivhiqagqcgnqigakfwevisdehgidptgsyhgdsdlqlerinvyyneaagnkyv
prailvdlepgtmdsvrsgpfgqifrpdnfvfgqsgagnnwakghytegaelvdsvldvv
rkesescdclqgfqlthslgggtgsgmgtlliskireeypdrimntfsvvpspkvsdtvv
epynatlsvhqlventdetycidnealydicfrtlklttptygdlnhlvsatmsgvttcl
rfpgqlnadlrklavnmvpfprlhffmpgfapltsrgsqqyraltvpeltqqmfdaknmm
aacdprhgryltvaavfrgrmsmkevdeqmlnvqnknssyfvewipnnvktavcdipprg
lkmsatfignstaiqelfkriseqftamfrrkaflhwytgegmdemefteaesnmndlvs
eyqqyqdatadeqgefeeegeedea

    Sequence, based on observed residues (ATOM records):
    >6ew0F (F:)
mreivhiqagqcgnqigakfwevisdehgidptgsyhgdsdlqlerinvyyneaagnkyv
prailvdlepgtmdsvrsgpfgqifrpdnfvfgqsgagnnwakghytegaelvdsvldvv
rkesescdclqgfqlthslgggtgsgmgtlliskireeypdrimntfsvvpspkvsdtvv
epynatlsvhqlventdetycidnealydicfrtlklttptygdlnhlvsatmsgvttcl
rfpgqlnadlrklavnmvpfprlhffmpgfapltsrgsqqyraltvpeltqqmfdaknmm
aacdprhgryltvaavfrgrmsmkevdeqmlnvqnknssyfvewipnnvktavcdipprg
lkmsatfignstaiqelfkriseqftamfrrkaflhwytgegmdemefteaesnmndlvs
eyqqyqdat

  • Chain 'G':
    Sequence, based on SEQRES records:
    >6ew0G (G:)
mreivhiqagqcgnqigakfwevisdehgidptgsyhgdsdlqlerinvyyneaagnkyv
prailvdlepgtmdsvrsgpfgqifrpdnfvfgqsgagnnwakghytegaelvdsvldvv
rkesescdclqgfqlthslgggtgsgmgtlliskireeypdrimntfsvvpspkvsdtvv
epynatlsvhqlventdetycidnealydicfrtlklttptygdlnhlvsatmsgvttcl
rfpgqlnadlrklavnmvpfprlhffmpgfapltsrgsqqyraltvpeltqqmfdaknmm
aacdprhgryltvaavfrgrmsmkevdeqmlnvqnknssyfvewipnnvktavcdipprg
lkmsatfignstaiqelfkriseqftamfrrkaflhwytgegmdemefteaesnmndlvs
eyqqyqdatadeqgefeeegeedea

    Sequence, based on observed residues (ATOM records):
    >6ew0G (G:)
mreivhiqagqcgnqigakfwevisdehgidptgsyhgdsdlqlerinvyyneaagnkyv
prailvdlepgtmdsvrsgpfgqifrpdnfvfgqsgagnnwakghytegaelvdsvldvv
rkesescdclqgfqlthslgggtgsgmgtlliskireeypdrimntfsvvpspkvsdtvv
epynatlsvhqlventdetycidnealydicfrtlklttptygdlnhlvsatmsgvttcl
rfpgqlnadlrklavnmvpfprlhffmpgfapltsrgsqqyraltvpeltqqmfdaknmm
aacdprhgryltvaavfrgrmsmkevdeqmlnvqnknssyfvewipnnvktavcdipprg
lkmsatfignstaiqelfkriseqftamfrrkaflhwytgegmdemefteaesnmndlvs
eyqqyqdat

  • Chain 'H':
    Sequence, based on SEQRES records:
    >6ew0H (H:)
mreivhiqagqcgnqigakfwevisdehgidptgsyhgdsdlqlerinvyyneaagnkyv
prailvdlepgtmdsvrsgpfgqifrpdnfvfgqsgagnnwakghytegaelvdsvldvv
rkesescdclqgfqlthslgggtgsgmgtlliskireeypdrimntfsvvpspkvsdtvv
epynatlsvhqlventdetycidnealydicfrtlklttptygdlnhlvsatmsgvttcl
rfpgqlnadlrklavnmvpfprlhffmpgfapltsrgsqqyraltvpeltqqmfdaknmm
aacdprhgryltvaavfrgrmsmkevdeqmlnvqnknssyfvewipnnvktavcdipprg
lkmsatfignstaiqelfkriseqftamfrrkaflhwytgegmdemefteaesnmndlvs
eyqqyqdatadeqgefeeegeedea

    Sequence, based on observed residues (ATOM records):
    >6ew0H (H:)
mreivhiqagqcgnqigakfwevisdehgidptgsyhgdsdlqlerinvyyneaagnkyv
prailvdlepgtmdsvrsgpfgqifrpdnfvfgqsgagnnwakghytegaelvdsvldvv
rkesescdclqgfqlthslgggtgsgmgtlliskireeypdrimntfsvvpspkvsdtvv
epynatlsvhqlventdetycidnealydicfrtlklttptygdlnhlvsatmsgvttcl
rfpgqlnadlrklavnmvpfprlhffmpgfapltsrgsqqyraltvpeltqqmfdaknmm
aacdprhgryltvaavfrgrmsmkevdeqmlnvqnknssyfvewipnnvktavcdipprg
lkmsatfignstaiqelfkriseqftamfrrkaflhwytgegmdemefteaesnmndlvs
eyqqyqdat

  • Chain 'I':
    Sequence, based on SEQRES records:
    >6ew0I (I:)
mreivhiqagqcgnqigakfwevisdehgidptgsyhgdsdlqlerinvyyneaagnkyv
prailvdlepgtmdsvrsgpfgqifrpdnfvfgqsgagnnwakghytegaelvdsvldvv
rkesescdclqgfqlthslgggtgsgmgtlliskireeypdrimntfsvvpspkvsdtvv
epynatlsvhqlventdetycidnealydicfrtlklttptygdlnhlvsatmsgvttcl
rfpgqlnadlrklavnmvpfprlhffmpgfapltsrgsqqyraltvpeltqqmfdaknmm
aacdprhgryltvaavfrgrmsmkevdeqmlnvqnknssyfvewipnnvktavcdipprg
lkmsatfignstaiqelfkriseqftamfrrkaflhwytgegmdemefteaesnmndlvs
eyqqyqdatadeqgefeeegeedea

    Sequence, based on observed residues (ATOM records):
    >6ew0I (I:)
mreivhiqagqcgnqigakfwevisdehgidptgsyhgdsdlqlerinvyyneaagnkyv
prailvdlepgtmdsvrsgpfgqifrpdnfvfgqsgagnnwakghytegaelvdsvldvv
rkesescdclqgfqlthslgggtgsgmgtlliskireeypdrimntfsvvpspkvsdtvv
epynatlsvhqlventdetycidnealydicfrtlklttptygdlnhlvsatmsgvttcl
rfpgqlnadlrklavnmvpfprlhffmpgfapltsrgsqqyraltvpeltqqmfdaknmm
aacdprhgryltvaavfrgrmsmkevdeqmlnvqnknssyfvewipnnvktavcdipprg
lkmsatfignstaiqelfkriseqftamfrrkaflhwytgegmdemefteaesnmndlvs
eyqqyqdat

  • Chain 'J':
    Sequence, based on SEQRES records:
    >6ew0J (J:)
mrecisihvgqagvqignacwelyclehgiqpdgqmpsdktigggddsfntffsetgagk
hvpravfvdleptvidevrtgtyrqlfhpeqlitgkedaannyarghytigkeiidlvld
rirkladqctglqgflvfhsfgggtgsgftsllmerlsvdygkksklefsiypapqvsta
vvepynsiltthttlehsdcafmvdneaiydicrrnldierptytnlnrlisqivssita
slrfdgalnvdltefqtnlvpyprihfplatyapvisaekayheqlsvaeitnacfepan
qmvkcdprhgkymaccllyrgdvvpkdvnaaiatiktkrsiqfvdwcptgfkvginyqpp
tvvpggdlakvqravcmlsnttaiaeawarldhkfdlmyakrafvhwyvgegmeegefse
aredmaalekdyeevgvdsvegegeeegeey

    Sequence, based on observed residues (ATOM records):
    >6ew0J (J:)
mrecisihvgqagvqignacwelyclehgiqpdgqmpdsfntffsetgagkhvpravfvd
leptvidevrtgtyrqlfhpeqlitgkedaannyarghytigkeiidlvldrirkladqc
tglqgflvfhsfgggtgsgftsllmerlsvdygkksklefsiypapqvstavvepynsil
tthttlehsdcafmvdneaiydicrrnldierptytnlnrlisqivssitaslrfdgaln
vdltefqtnlvpyprihfplatyapvisaekayheqlsvaeitnacfepanqmvkcdprh
gkymaccllyrgdvvpkdvnaaiatiktkrsiqfvdwcptgfkvginyqpptvvpggdla
kvqravcmlsnttaiaeawarldhkfdlmyakrafvhwyvgegmeegefsearedmaale
kdyeevgvdsve

  • Chain 'K':
    Sequence, based on SEQRES records:
    >6ew0K (K:)
mrecisihvgqagvqignacwelyclehgiqpdgqmpsdktigggddsfntffsetgagk
hvpravfvdleptvidevrtgtyrqlfhpeqlitgkedaannyarghytigkeiidlvld
rirkladqctglqgflvfhsfgggtgsgftsllmerlsvdygkksklefsiypapqvsta
vvepynsiltthttlehsdcafmvdneaiydicrrnldierptytnlnrlisqivssita
slrfdgalnvdltefqtnlvpyprihfplatyapvisaekayheqlsvaeitnacfepan
qmvkcdprhgkymaccllyrgdvvpkdvnaaiatiktkrsiqfvdwcptgfkvginyqpp
tvvpggdlakvqravcmlsnttaiaeawarldhkfdlmyakrafvhwyvgegmeegefse
aredmaalekdyeevgvdsvegegeeegeey

    Sequence, based on observed residues (ATOM records):
    >6ew0K (K:)
mrecisihvgqagvqignacwelyclehgiqpdgqmpdsfntffsetgagkhvpravfvd
leptvidevrtgtyrqlfhpeqlitgkedaannyarghytigkeiidlvldrirkladqc
tglqgflvfhsfgggtgsgftsllmerlsvdygkksklefsiypapqvstavvepynsil
tthttlehsdcafmvdneaiydicrrnldierptytnlnrlisqivssitaslrfdgaln
vdltefqtnlvpyprihfplatyapvisaekayheqlsvaeitnacfepanqmvkcdprh
gkymaccllyrgdvvpkdvnaaiatiktkrsiqfvdwcptgfkvginyqpptvvpggdla
kvqravcmlsnttaiaeawarldhkfdlmyakrafvhwyvgegmeegefsearedmaale
kdyeevgvdsve

  • Chain 'L':
    Sequence, based on SEQRES records:
    >6ew0L (L:)
mrecisihvgqagvqignacwelyclehgiqpdgqmpsdktigggddsfntffsetgagk
hvpravfvdleptvidevrtgtyrqlfhpeqlitgkedaannyarghytigkeiidlvld
rirkladqctglqgflvfhsfgggtgsgftsllmerlsvdygkksklefsiypapqvsta
vvepynsiltthttlehsdcafmvdneaiydicrrnldierptytnlnrlisqivssita
slrfdgalnvdltefqtnlvpyprihfplatyapvisaekayheqlsvaeitnacfepan
qmvkcdprhgkymaccllyrgdvvpkdvnaaiatiktkrsiqfvdwcptgfkvginyqpp
tvvpggdlakvqravcmlsnttaiaeawarldhkfdlmyakrafvhwyvgegmeegefse
aredmaalekdyeevgvdsvegegeeegeey

    Sequence, based on observed residues (ATOM records):
    >6ew0L (L:)
mrecisihvgqagvqignacwelyclehgiqpdgqmpdsfntffsetgagkhvpravfvd
leptvidevrtgtyrqlfhpeqlitgkedaannyarghytigkeiidlvldrirkladqc
tglqgflvfhsfgggtgsgftsllmerlsvdygkksklefsiypapqvstavvepynsil
tthttlehsdcafmvdneaiydicrrnldierptytnlnrlisqivssitaslrfdgaln
vdltefqtnlvpyprihfplatyapvisaekayheqlsvaeitnacfepanqmvkcdprh
gkymaccllyrgdvvpkdvnaaiatiktkrsiqfvdwcptgfkvginyqpptvvpggdla
kvqravcmlsnttaiaeawarldhkfdlmyakrafvhwyvgegmeegefsearedmaale
kdyeevgvdsve