PDB entry 6esq

View 6esq on RCSB PDB site
Description: structure of the acetoacetyl-coa thiolase/hmg-coa synthase complex from methanothermococcus thermolithotrophicus soaked with acetyl-coa
Deposited on 2017-10-24, released 2018-03-14
The last revision was dated 2018-04-11, with a file datestamp of 2018-04-06.
Experiment type: XRAY
Resolution: 2.95 Å
R-factor: N/A
AEROSPACI score: 0.14 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: acetoacetyl-CoA thiolase
    Species: Methanothermococcus thermolithotrophicus [TaxId:2186]
    Database cross-references and differences (RAF-indexed):
    • PDB 6ESQ (0-391)
  • Chain 'B':
    Compound: acetoacetyl-CoA thiolase
    Species: Methanothermococcus thermolithotrophicus [TaxId:2186]
    Database cross-references and differences (RAF-indexed):
    • PDB 6ESQ (0-391)
  • Chain 'C':
    Compound: acetoacetyl-CoA thiolase
    Species: Methanothermococcus thermolithotrophicus [TaxId:2186]
    Database cross-references and differences (RAF-indexed):
    • PDB 6ESQ (0-391)
  • Chain 'D':
    Compound: acetoacetyl-CoA thiolase
    Species: Methanothermococcus thermolithotrophicus [TaxId:2186]
    Database cross-references and differences (RAF-indexed):
    • PDB 6ESQ (0-391)
  • Chain 'E':
    Compound: Pfam DUF35
    Species: Methanothermococcus thermolithotrophicus [TaxId:2186]
    Database cross-references and differences (RAF-indexed):
    • PDB 6ESQ
  • Chain 'F':
    Compound: Pfam DUF35
    Species: Methanothermococcus thermolithotrophicus [TaxId:2186]
    Database cross-references and differences (RAF-indexed):
    • PDB 6ESQ (Start-129)
  • Chain 'G':
    Compound: Pfam DUF35
    Species: Methanothermococcus thermolithotrophicus [TaxId:2186]
    Database cross-references and differences (RAF-indexed):
    • PDB 6ESQ
  • Chain 'H':
    Compound: Pfam DUF35
    Species: Methanothermococcus thermolithotrophicus [TaxId:2186]
    Database cross-references and differences (RAF-indexed):
    • PDB 6ESQ
  • Chain 'I':
    Compound: Hydroxymethylglutaryl-CoA synthase
    Species: Methanothermococcus thermolithotrophicus [TaxId:2186]
    Database cross-references and differences (RAF-indexed):
    • PDB 6ESQ
  • Chain 'J':
    Compound: Hydroxymethylglutaryl-CoA synthase
    Species: Methanothermococcus thermolithotrophicus [TaxId:2186]
    Database cross-references and differences (RAF-indexed):
    • PDB 6ESQ (Start-348)
  • Chain 'K':
    Compound: Hydroxymethylglutaryl-CoA synthase
    Species: Methanothermococcus thermolithotrophicus [TaxId:2186]
    Database cross-references and differences (RAF-indexed):
    • PDB 6ESQ
  • Chain 'L':
    Compound: Hydroxymethylglutaryl-CoA synthase
    Species: Methanothermococcus thermolithotrophicus [TaxId:2186]
    Database cross-references and differences (RAF-indexed):
    • PDB 6ESQ
  • Heterogens: COA, K, ZN, CL, NA, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records:
    >6esqA (A:)
mrdvaiigygqtkfgelwedsfrdliveagvkaikdanvdggdidamyignmsgglfvgq
ehiasliadhaglnpvpctrveaacasgslalrsavlsvasghhdvvlaggvekmtdved
ataaiasasdqeweaffgatfpslyammarrymyqygltieelsmwsviahenatknkya
qfgfkttleqvmnaspvadpltlmhcspvsdgasalivcdadkaeefapkdeiiyikast
qasdtialhdredmttlnaakvasekayklakiapekidvaevhdcfainglilvedlgf
ckkgdagkvidegkiridyddfvtvnpsgglkaaghalgatgirqvgelywqlkqdkeck
drqatikngygiaanvggtggtvcvhllsdkr

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records:
    >6esqB (B:)
mrdvaiigygqtkfgelwedsfrdliveagvkaikdanvdggdidamyignmsgglfvgq
ehiasliadhaglnpvpctrveaacasgslalrsavlsvasghhdvvlaggvekmtdved
ataaiasasdqeweaffgatfpslyammarrymyqygltieelsmwsviahenatknkya
qfgfkttleqvmnaspvadpltlmhcspvsdgasalivcdadkaeefapkdeiiyikast
qasdtialhdredmttlnaakvasekayklakiapekidvaevhdcfainglilvedlgf
ckkgdagkvidegkiridyddfvtvnpsgglkaaghalgatgirqvgelywqlkqdkeck
drqatikngygiaanvggtggtvcvhllsdkr

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records:
    >6esqC (C:)
mrdvaiigygqtkfgelwedsfrdliveagvkaikdanvdggdidamyignmsgglfvgq
ehiasliadhaglnpvpctrveaacasgslalrsavlsvasghhdvvlaggvekmtdved
ataaiasasdqeweaffgatfpslyammarrymyqygltieelsmwsviahenatknkya
qfgfkttleqvmnaspvadpltlmhcspvsdgasalivcdadkaeefapkdeiiyikast
qasdtialhdredmttlnaakvasekayklakiapekidvaevhdcfainglilvedlgf
ckkgdagkvidegkiridyddfvtvnpsgglkaaghalgatgirqvgelywqlkqdkeck
drqatikngygiaanvggtggtvcvhllsdkr

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records:
    >6esqD (D:)
mrdvaiigygqtkfgelwedsfrdliveagvkaikdanvdggdidamyignmsgglfvgq
ehiasliadhaglnpvpctrveaacasgslalrsavlsvasghhdvvlaggvekmtdved
ataaiasasdqeweaffgatfpslyammarrymyqygltieelsmwsviahenatknkya
qfgfkttleqvmnaspvadpltlmhcspvsdgasalivcdadkaeefapkdeiiyikast
qasdtialhdredmttlnaakvasekayklakiapekidvaevhdcfainglilvedlgf
ckkgdagkvidegkiridyddfvtvnpsgglkaaghalgatgirqvgelywqlkqdkeck
drqatikngygiaanvggtggtvcvhllsdkr

  • Chain 'E':
    Sequence, based on SEQRES records:
    >6esqE (E:)
mvvrswrhmkerynligtrcktcgkvyfpsrtvcpdcrrkgeleefqlsgkgkiytysiv
yappkefnkltpyviaiveleegpkvtaqvdcdinkisigipveaafrrikedgkdgiis
ygykfvpite

    Sequence, based on observed residues (ATOM records):
    >6esqE (E:)
vvrswrhmkerynligtrcktcgkvyfpsrtvcpdcrrkgeleefqlsgkgkiytysivy
appkefnkltpyviaiveleegpkvtaqvdcdinkisigipveaafrrikedgkdgiisy
gykfvpi

  • Chain 'F':
    Sequence, based on SEQRES records:
    >6esqF (F:)
mvvrswrhmkerynligtrcktcgkvyfpsrtvcpdcrrkgeleefqlsgkgkiytysiv
yappkefnkltpyviaiveleegpkvtaqvdcdinkisigipveaafrrikedgkdgiis
ygykfvpite

    Sequence, based on observed residues (ATOM records):
    >6esqF (F:)
vvrswrhmkerynligtrcktcgkvyfpsrtvcpdcrrkgeleefqlsgkgkiytysivy
appkefnkltpyviaiveleegpkvtaqvdcdinkisigipveaafrrikedgkdgiisy
gykfvpite

  • Chain 'G':
    Sequence, based on SEQRES records:
    >6esqG (G:)
mvvrswrhmkerynligtrcktcgkvyfpsrtvcpdcrrkgeleefqlsgkgkiytysiv
yappkefnkltpyviaiveleegpkvtaqvdcdinkisigipveaafrrikedgkdgiis
ygykfvpite

    Sequence, based on observed residues (ATOM records):
    >6esqG (G:)
vvrswrhmkerynligtrcktcgkvyfpsrtvcpdcrrkgeleefqlsgkgkiytysivy
appkefnkltpyviaiveleegpkvtaqvdcdinkisigipveaafrrikedgkdgiisy
gykfvpit

  • Chain 'H':
    Sequence, based on SEQRES records:
    >6esqH (H:)
mvvrswrhmkerynligtrcktcgkvyfpsrtvcpdcrrkgeleefqlsgkgkiytysiv
yappkefnkltpyviaiveleegpkvtaqvdcdinkisigipveaafrrikedgkdgiis
ygykfvpite

    Sequence, based on observed residues (ATOM records):
    >6esqH (H:)
vvrswrhmkerynligtrcktcgkvyfpsrtvcpdcrrkgeleefqlsgkgkiytysivy
appkefnkltpyviaiveleegpkvtaqvdcdinkisigipveaafrrikedgkdgiisy
gykfvpit

  • Chain 'I':
    Sequence, based on SEQRES records:
    >6esqI (I:)
mkdigivgygsyipkyrikveeiakvwgkdpeaikkglvvneksvpspdedtatiaveaa
rnavkraginaekigavyvgseshpyavkptsatvaeaigatpdltaadlefackagtag
iqmcmglvgsglieygmaigadtaqgapgdaleytasaggaayiignkkdemiavfngty
syttdtpdfwrregqsypkhggrftgepayfkhvlnaakgimekmgttvkdydycvfhqp
ngkfyikaakslgftneqykyglltpylgntysgavplglsnildhaeegarilavsygs
gagsdafditvterikevvdkapktldllnrkkyidyavyvkyrgkiki

    Sequence, based on observed residues (ATOM records):
    >6esqI (I:)
kdigivgygsyipkyrikveeiakvwgkdpeaikkglvvneksvpspdedtatiaveaar
navkraginaekigavyvgseshpyavkptsatvaeaigatpdltaadlefackagtagi
qmcmglvgsglieygmaigadtaqgapgdaleytasaggaayiignkkdemiavfngtys
yttdtpdfwrregqsypkhggrftgepayfkhvlnaakgimekmgttvkdydycvfhqpn
gkfyikaakslgftneqykyglltpylgntysgavplglsnildhaeegarilavsygsg
agsdafditvterikevvdkapktldllnrkkyidyavyvkyrgkik

  • Chain 'J':
    Sequence, based on SEQRES records:
    >6esqJ (J:)
mkdigivgygsyipkyrikveeiakvwgkdpeaikkglvvneksvpspdedtatiaveaa
rnavkraginaekigavyvgseshpyavkptsatvaeaigatpdltaadlefackagtag
iqmcmglvgsglieygmaigadtaqgapgdaleytasaggaayiignkkdemiavfngty
syttdtpdfwrregqsypkhggrftgepayfkhvlnaakgimekmgttvkdydycvfhqp
ngkfyikaakslgftneqykyglltpylgntysgavplglsnildhaeegarilavsygs
gagsdafditvterikevvdkapktldllnrkkyidyavyvkyrgkiki

    Sequence, based on observed residues (ATOM records):
    >6esqJ (J:)
kdigivgygsyipkyrikveeiakvwgkdpeaikkglvvneksvpspdedtatiaveaar
navkraginaekigavyvgseshpyavkptsatvaeaigatpdltaadlefackagtagi
qmcmglvgsglieygmaigadtaqgapgdaleytasaggaayiignkkdemiavfngtys
yttdtpdfwrregqsypkhggrftgepayfkhvlnaakgimekmgttvkdydycvfhqpn
gkfyikaakslgftneqykyglltpylgntysgavplglsnildhaeegarilavsygsg
agsdafditvterikevvdkapktldllnrkkyidyavyvkyrgkiki

  • Chain 'K':
    Sequence, based on SEQRES records:
    >6esqK (K:)
mkdigivgygsyipkyrikveeiakvwgkdpeaikkglvvneksvpspdedtatiaveaa
rnavkraginaekigavyvgseshpyavkptsatvaeaigatpdltaadlefackagtag
iqmcmglvgsglieygmaigadtaqgapgdaleytasaggaayiignkkdemiavfngty
syttdtpdfwrregqsypkhggrftgepayfkhvlnaakgimekmgttvkdydycvfhqp
ngkfyikaakslgftneqykyglltpylgntysgavplglsnildhaeegarilavsygs
gagsdafditvterikevvdkapktldllnrkkyidyavyvkyrgkiki

    Sequence, based on observed residues (ATOM records):
    >6esqK (K:)
kdigivgygsyipkyrikveeiakvwgkdpeaikkglvvneksvpspdedtatiaveaar
navkraginaekigavyvgseshpyavkptsatvaeaigatpdltaadlefackagtagi
qmcmglvgsglieygmaigadtaqgapgdaleytasaggaayiignkkdemiavfngtys
yttdtpdfwrregqsypkhggrftgepayfkhvlnaakgimekmgttvkdydycvfhqpn
gkfyikaakslgftneqykyglltpylgntysgavplglsnildhaeegarilavsygsg
agsdafditvterikevvdkapktldllnrkkyidyavyvkyrgkik

  • Chain 'L':
    Sequence, based on SEQRES records:
    >6esqL (L:)
mkdigivgygsyipkyrikveeiakvwgkdpeaikkglvvneksvpspdedtatiaveaa
rnavkraginaekigavyvgseshpyavkptsatvaeaigatpdltaadlefackagtag
iqmcmglvgsglieygmaigadtaqgapgdaleytasaggaayiignkkdemiavfngty
syttdtpdfwrregqsypkhggrftgepayfkhvlnaakgimekmgttvkdydycvfhqp
ngkfyikaakslgftneqykyglltpylgntysgavplglsnildhaeegarilavsygs
gagsdafditvterikevvdkapktldllnrkkyidyavyvkyrgkiki

    Sequence, based on observed residues (ATOM records):
    >6esqL (L:)
kdigivgygsyipkyrikveeiakvwgkdpeaikkglvvneksvpspdedtatiaveaar
navkraginaekigavyvgseshpyavkptsatvaeaigatpdltaadlefackagtagi
qmcmglvgsglieygmaigadtaqgapgdaleytasaggaayiignkkdemiavfngtys
yttdtpdfwrregqsypkhggrftgepayfkhvlnaakgimekmgttvkdydycvfhqpn
gkfyikaakslgftneqykyglltpylgntysgavplglsnildhaeegarilavsygsg
agsdafditvterikevvdkapktldllnrkkyidyavyvkyrgkik