PDB entry 6es0

View 6es0 on RCSB PDB site
Description: Crystal structure of the kinase domain of human RIPK2 in complex with the activation loop targeting inhibitor CS-R35
Class: transferase
Keywords: Kinase Inhibitor, TRANSFERASE
Deposited on 2017-10-19, released 2018-02-21
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-10-16, with a file datestamp of 2019-10-11.
Experiment type: XRAY
Resolution: 2.38 Å
R-factor: N/A
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: receptor-interacting serine/threonine-protein kinase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: RIPK2, CARDIAK, RICK, RIP2, UNQ277/PRO314/PRO34092
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6es0a_
  • Chain 'B':
    Compound: receptor-interacting serine/threonine-protein kinase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: RIPK2, CARDIAK, RICK, RIP2, UNQ277/PRO314/PRO34092
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6es0b_
  • Heterogens: BW8, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6es0A (A:)
smgeaicsalptipyhkladlrylsrgasgtvssarhadwrvqvavkhlhihtplldser
kdvlreaeilhkarfsyilpilgicnepeflgivteympngslnellhrkteypdvawpl
rfrilheialgvnylhnmtppllhhdlktqnilldnefhvkiadfglskwrmmslsqsrs
sksapeggtiiymppenyepgqksrasikhdiysyavitwevlsrkqpfedvtnplqimy
svsqghrpvineeslpydiphrarmisliesgwaqnpderpsflkclielepvlrtfeei
tfleaviqlkktklqsv

    Sequence, based on observed residues (ATOM records): (download) 
    >6es0A (A:)
aicsalptipyhkladlrylsrgasgtvssarhadwrvqvavkhlhihtplldserkdvl
reaeilhkarfsyilpilgicnepeflgivteympngslnellhrkteypdvawplrfri
lheialgvnylhnmtppllhhdlktqnilldnefhvkiadfglskwgtiiymppenyasi
khdiysyavitwevlsrkqpfedvtnplqimysvsqghrpvineeslpydiphrarmisl
iesgwaqnpderpsflkclielepvlrtfeeitfleaviqlkktklqs

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6es0B (B:)
smgeaicsalptipyhkladlrylsrgasgtvssarhadwrvqvavkhlhihtplldser
kdvlreaeilhkarfsyilpilgicnepeflgivteympngslnellhrkteypdvawpl
rfrilheialgvnylhnmtppllhhdlktqnilldnefhvkiadfglskwrmmslsqsrs
sksapeggtiiymppenyepgqksrasikhdiysyavitwevlsrkqpfedvtnplqimy
svsqghrpvineeslpydiphrarmisliesgwaqnpderpsflkclielepvlrtfeei
tfleaviqlkktklqsv

    Sequence, based on observed residues (ATOM records): (download) 
    >6es0B (B:)
aicsalptipyhkladlrylsrgasgtvssarhadwrvqvavkhlserkdvlreaeilhk
arfsyilpilgicnepeflgivteympngslnellhrkteypdvawplrfrilheialgv
nylhnmtppllhhdlktqnilldnefhvkiadfglskwrgtiiymppenyepgqksrasi
khdiysyavitwevlsrkqpfedvtnplqimysvsqghrpvineeslpydiphrarmisl
iesgwaqnpderpsflkclielepvlrtfeeitfleaviqlkktklq