PDB entry 6erx

View 6erx on RCSB PDB site
Description: crystal structure of human baff in complex with fab fragment of anti- baff antibody belimumab
Deposited on 2017-10-19, released 2018-01-31
Made obsolete by 6fxn on 2018-04-04

The last revision was dated 2018-04-04, with a file datestamp of 2018-03-29.
Experiment type: XRAY
Resolution: 2.9 Å
R-factor: N/A
AEROSPACI score: 0.15 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: tumor necrosis factor ligand superfamily member 13b
    Species: Homo sapiens [TaxId:9606]
    Gene: TNFSF13B, BAFF, BLYS, TALL1, TNFSF20, ZTNF4, UNQ401/PRO738
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9Y275 (Start-163)
      • engineered mutation (96)
  • Chain 'B':
    Compound: tumor necrosis factor ligand superfamily member 13b
    Species: Homo sapiens [TaxId:9606]
    Gene: TNFSF13B, BAFF, BLYS, TALL1, TNFSF20, ZTNF4, UNQ401/PRO738
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9Y275 (Start-163)
      • engineered mutation (96)
  • Chain 'C':
    Compound: tumor necrosis factor ligand superfamily member 13b
    Species: Homo sapiens [TaxId:9606]
    Gene: TNFSF13B, BAFF, BLYS, TALL1, TNFSF20, ZTNF4, UNQ401/PRO738
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9Y275 (Start-163)
      • engineered mutation (96)
  • Chain 'D':
    Compound: belimumab heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6ERX (0-End)
  • Chain 'E':
    Compound: belimumab light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6ERX
  • Chain 'F':
    Compound: belimumab heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6ERX (Start-223)
  • Chain 'G':
    Compound: belimumab light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6ERX
  • Chain 'H':
    Compound: belimumab heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6ERX (Start-223)
  • Chain 'I':
    Compound: belimumab light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6ERX
  • Chain 'J':
    Compound: tumor necrosis factor ligand superfamily member 13b
    Species: Homo sapiens [TaxId:9606]
    Gene: TNFSF13B, BAFF, BLYS, TALL1, TNFSF20, ZTNF4, UNQ401/PRO738
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9Y275 (Start-163)
      • engineered mutation (96)
  • Chain 'K':
    Compound: tumor necrosis factor ligand superfamily member 13b
    Species: Homo sapiens [TaxId:9606]
    Gene: TNFSF13B, BAFF, BLYS, TALL1, TNFSF20, ZTNF4, UNQ401/PRO738
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9Y275 (Start-163)
      • engineered mutation (96)
  • Chain 'L':
    Compound: tumor necrosis factor ligand superfamily member 13b
    Species: Homo sapiens [TaxId:9606]
    Gene: TNFSF13B, BAFF, BLYS, TALL1, TNFSF20, ZTNF4, UNQ401/PRO738
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9Y275 (Start-163)
      • engineered mutation (96)
  • Chain 'M':
    Compound: belimumab heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6ERX
  • Chain 'N':
    Compound: belimumab light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6ERX
  • Chain 'O':
    Compound: belimumab heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6ERX (0-End)
  • Chain 'P':
    Compound: belimumab light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6ERX
  • Chain 'Q':
    Compound: belimumab heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6ERX
  • Chain 'R':
    Compound: belimumab light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6ERX
  • Heterogens: HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6erxA (A:)
mrgshhhhhhgsavqgpeetvtqdclqliadsetptiqkgsytfvpwllsfkrgsaleek
enkilvketgyffiygqvlytdktyamghliqrkkvavfgdelslvtlfrciqnmpetlp
nnscysagiakleegdelqlaiprenaqisldgdvtffgalkll

    Sequence, based on observed residues (ATOM records):
    >6erxA (A:)
vtqdclqliadsetptiqkgsytfvpwllsfkrgsaleekenkilvketgyffiygqvly
tdktyamghliqrkkvavfgdelslvtlfrciqnmpetlpnnscysagiakleegdelql
aiprenaqisldgdvtffgalkll

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6erxB (B:)
mrgshhhhhhgsavqgpeetvtqdclqliadsetptiqkgsytfvpwllsfkrgsaleek
enkilvketgyffiygqvlytdktyamghliqrkkvavfgdelslvtlfrciqnmpetlp
nnscysagiakleegdelqlaiprenaqisldgdvtffgalkll

    Sequence, based on observed residues (ATOM records):
    >6erxB (B:)
vtqdclqliadsetptiqkgsytfvpwllsfkrgsaleekenkilvketgyffiygqvly
tdktyamghliqrkkvavfgdelslvtlfrciqnmpetlpnnscysagiakleegdelql
aiprenaqisldgdvtffgalkll

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6erxC (C:)
mrgshhhhhhgsavqgpeetvtqdclqliadsetptiqkgsytfvpwllsfkrgsaleek
enkilvketgyffiygqvlytdktyamghliqrkkvavfgdelslvtlfrciqnmpetlp
nnscysagiakleegdelqlaiprenaqisldgdvtffgalkll

    Sequence, based on observed residues (ATOM records):
    >6erxC (C:)
vtqdclqliadsetptiqkgsytfvpwllsfkrgsaleekenkilvketgyffiygqvly
tdktyamghliqrkkvavfgdelslvtlfrciqnmpetlpnnscysagiakleegdelql
aiprenaqisldgdvtffgalkll

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6erxD (D:)
qvqlqqsgaevkkpgssvrvsckasggtfnnnainwvrqapgqglewmggiipmfgtaky
sqnfqgrvaitadeststasmelsslrsedtavyycarsrdlllfphygmdvwgrgtmvt
vssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavl
qssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkrveps

    Sequence, based on observed residues (ATOM records):
    >6erxD (D:)
qvqlqqsgaevkkpgssvrvsckasggtfnnnainwvrqapgqglewmggiipmfgtaky
sqnfqgrvaitadeststasmelsslrsedtavyycarsrdlllfphygmdvwgrgtmvt
vssastkgpsvfplapstaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglys
lssvvtvpssslgtqtyicnvnhkpsntkvdkrve

  • Chain 'E':
    Sequence, based on SEQRES records:
    >6erxE (E:)
sseltqdpavsvalgqtvrvtcqgdslrsyyaswyqqkpgqapvlviygknnrpsgipdr
fsgsssgntasltitgaqaedeadyycnsrdssgnhwvfgggteltvlgqpkaapsvtlf
ppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaassyl
sltpeqwkshrsyscqvthegstvektvaptecs

    Sequence, based on observed residues (ATOM records):
    >6erxE (E:)
eltqdpavsvalgqtvrvtcqgdslrsyyaswyqqkpgqapvlviygknnrpsgipdrfs
gsssgntasltitgaqaedeadyycnsrdssgnhwvfgggteltvlgqpkaapsvtlfpp
sseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaassylsl
tpeqwkshrsyscqvthegstvektvapt

  • Chain 'F':
    Sequence, based on SEQRES records:
    >6erxF (F:)
qvqlqqsgaevkkpgssvrvsckasggtfnnnainwvrqapgqglewmggiipmfgtaky
sqnfqgrvaitadeststasmelsslrsedtavyycarsrdlllfphygmdvwgrgtmvt
vssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavl
qssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkrveps

    Sequence, based on observed residues (ATOM records):
    >6erxF (F:)
vqlqqsgaevkkpgssvrvsckasggtfnnnainwvrqapgqglewmggiipmfgtakys
qnfqgrvaitadeststasmelsslrsedtavyycarsrdlllfphygmdvwgrgtmvtv
ssastkgpsvfplapstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssg
lyslssvvtvpssslgtqtyicnvnhkpsntkvdkrveps

  • Chain 'G':
    Sequence, based on SEQRES records:
    >6erxG (G:)
sseltqdpavsvalgqtvrvtcqgdslrsyyaswyqqkpgqapvlviygknnrpsgipdr
fsgsssgntasltitgaqaedeadyycnsrdssgnhwvfgggteltvlgqpkaapsvtlf
ppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaassyl
sltpeqwkshrsyscqvthegstvektvaptecs

    Sequence, based on observed residues (ATOM records):
    >6erxG (G:)
seltqdpavsvalgqtvrvtcqgdslrsyyaswyqqkpgqapvlviygknnrpsgipdrf
sgsssgntasltitgaqaedeadyycnsrdssgnhwvfgggteltvlgqpkaapsvtlfp
psseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaassyls
ltpeqwkshrsyscqvthegstvektvapt

  • Chain 'H':
    Sequence, based on SEQRES records:
    >6erxH (H:)
qvqlqqsgaevkkpgssvrvsckasggtfnnnainwvrqapgqglewmggiipmfgtaky
sqnfqgrvaitadeststasmelsslrsedtavyycarsrdlllfphygmdvwgrgtmvt
vssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavl
qssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkrveps

    Sequence, based on observed residues (ATOM records):
    >6erxH (H:)
vqlqqsgaevkkpgssvrvsckasggtfnnnainwvrqapgqglewmggiipmfgtakys
qnfqgrvaitadeststasmelsslrsedtavyycarsrdlllfphygmdvwgrgtmvtv
ssastkgpsvfplapstaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglysl
ssvvtvpssslgtqtyicnvnhkpsntkvdkrveps

  • Chain 'I':
    Sequence, based on SEQRES records:
    >6erxI (I:)
sseltqdpavsvalgqtvrvtcqgdslrsyyaswyqqkpgqapvlviygknnrpsgipdr
fsgsssgntasltitgaqaedeadyycnsrdssgnhwvfgggteltvlgqpkaapsvtlf
ppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaassyl
sltpeqwkshrsyscqvthegstvektvaptecs

    Sequence, based on observed residues (ATOM records):
    >6erxI (I:)
seltqdpavsvalgqtvrvtcqgdslrsyyaswyqqkpgqapvlviygknnrpsgipdrf
sgsssgntasltitgaqaedeadyycnsrdssgnhwvfgggteltvlgqpkaapsvtlfp
psseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaassyls
ltpeqwkshrsyscqvthegstvektvapt

  • Chain 'J':
    Sequence, based on SEQRES records:
    >6erxJ (J:)
mrgshhhhhhgsavqgpeetvtqdclqliadsetptiqkgsytfvpwllsfkrgsaleek
enkilvketgyffiygqvlytdktyamghliqrkkvavfgdelslvtlfrciqnmpetlp
nnscysagiakleegdelqlaiprenaqisldgdvtffgalkll

    Sequence, based on observed residues (ATOM records):
    >6erxJ (J:)
vtqdclqliadsetptiqkgsytfvpwllsfkrgsaleekenkilvketgyffiygqvly
tdktyamghliqrkkvavfgdelslvtlfrciqnmpetlpnnscysagiakleegdelql
aiprenaqisldgdvtffgalkll

  • Chain 'K':
    Sequence, based on SEQRES records:
    >6erxK (K:)
mrgshhhhhhgsavqgpeetvtqdclqliadsetptiqkgsytfvpwllsfkrgsaleek
enkilvketgyffiygqvlytdktyamghliqrkkvavfgdelslvtlfrciqnmpetlp
nnscysagiakleegdelqlaiprenaqisldgdvtffgalkll

    Sequence, based on observed residues (ATOM records):
    >6erxK (K:)
vtqdclqliadsetptiqkgsytfvpwllsfkrgsaleekenkilvketgyffiygqvly
tdktyamghliqrkkvavfgdelslvtlfrciqnmpetlpnnscysagiakleegdelql
aiprenaqisldgdvtffgalkll

  • Chain 'L':
    Sequence, based on SEQRES records:
    >6erxL (L:)
mrgshhhhhhgsavqgpeetvtqdclqliadsetptiqkgsytfvpwllsfkrgsaleek
enkilvketgyffiygqvlytdktyamghliqrkkvavfgdelslvtlfrciqnmpetlp
nnscysagiakleegdelqlaiprenaqisldgdvtffgalkll

    Sequence, based on observed residues (ATOM records):
    >6erxL (L:)
vtqdclqliadsetptiqkgsytfvpwllsfkrgsaleekenkilvketgyffiygqvly
tdktyamghliqrkkvavfgdelslvtlfrciqnmpetlpnnscysagiakleegdelql
aiprenaqisldgdvtffgalkll

  • Chain 'M':
    Sequence, based on SEQRES records:
    >6erxM (M:)
qvqlqqsgaevkkpgssvrvsckasggtfnnnainwvrqapgqglewmggiipmfgtaky
sqnfqgrvaitadeststasmelsslrsedtavyycarsrdlllfphygmdvwgrgtmvt
vssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavl
qssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkrveps

    Sequence, based on observed residues (ATOM records):
    >6erxM (M:)
vqlqqsgaevkkpgssvrvsckasggtfnnnainwvrqapgqglewmggiipmfgtakys
qnfqgrvaitadeststasmelsslrsedtavyycarsrdlllfphygmdvwgrgtmvtv
ssastkgpsvfplapstaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglysl
ssvvtvpssslgtqtyicnvnhkpsntkvdkrvep

  • Chain 'N':
    Sequence, based on SEQRES records:
    >6erxN (N:)
sseltqdpavsvalgqtvrvtcqgdslrsyyaswyqqkpgqapvlviygknnrpsgipdr
fsgsssgntasltitgaqaedeadyycnsrdssgnhwvfgggteltvlgqpkaapsvtlf
ppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaassyl
sltpeqwkshrsyscqvthegstvektvaptecs

    Sequence, based on observed residues (ATOM records):
    >6erxN (N:)
seltqdpavsvalgqtvrvtcqgdslrsyyaswyqqkpgqapvlviygknnrpsgipdrf
sgsssgntasltitgaqaedeadyycnsrdssgnhwvfgggteltvlgqpkaapsvtlfp
psseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaassyls
ltpeqwkshrsyscqvthegstvektvapt

  • Chain 'O':
    Sequence, based on SEQRES records:
    >6erxO (O:)
qvqlqqsgaevkkpgssvrvsckasggtfnnnainwvrqapgqglewmggiipmfgtaky
sqnfqgrvaitadeststasmelsslrsedtavyycarsrdlllfphygmdvwgrgtmvt
vssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavl
qssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkrveps

    Sequence, based on observed residues (ATOM records):
    >6erxO (O:)
qvqlqqsgaevkkpgssvrvsckasggtfnnnainwvrqapgqglewmggiipmfgtaky
sqnfqgrvaitadeststasmelsslrsedtavyycarsrdlllfphygmdvwgrgtmvt
vssastkgpsvfplaptaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglysl
ssvvtvpssslgtqtyicnvnhkpsntkvdkrvep

  • Chain 'P':
    Sequence, based on SEQRES records:
    >6erxP (P:)
sseltqdpavsvalgqtvrvtcqgdslrsyyaswyqqkpgqapvlviygknnrpsgipdr
fsgsssgntasltitgaqaedeadyycnsrdssgnhwvfgggteltvlgqpkaapsvtlf
ppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaassyl
sltpeqwkshrsyscqvthegstvektvaptecs

    Sequence, based on observed residues (ATOM records):
    >6erxP (P:)
seltqdpavsvalgqtvrvtcqgdslrsyyaswyqqkpgqapvlviygknnrpsgipdrf
sgsssgntasltitgaqaedeadyycnsrdssgnhwvfgggteltvlgqpkaapsvtlfp
psseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaassyls
ltpeqwkshrsyscqvthegstvektvapt

  • Chain 'Q':
    Sequence, based on SEQRES records:
    >6erxQ (Q:)
qvqlqqsgaevkkpgssvrvsckasggtfnnnainwvrqapgqglewmggiipmfgtaky
sqnfqgrvaitadeststasmelsslrsedtavyycarsrdlllfphygmdvwgrgtmvt
vssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavl
qssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkrveps

    Sequence, based on observed residues (ATOM records):
    >6erxQ (Q:)
vqlqqsgaevkkpgssvrvsckasggtfnnnainwvrqapgqglewmggiipmfgtakys
qnfqgrvaitadeststasmelsslrsedtavyycarsrdlllfphygmdvwgrgtmvtv
ssastkgpsvfplapstaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglysl
ssvvtvpssslgtqtyicnvnhkpsntkvdkrvep

  • Chain 'R':
    Sequence, based on SEQRES records:
    >6erxR (R:)
sseltqdpavsvalgqtvrvtcqgdslrsyyaswyqqkpgqapvlviygknnrpsgipdr
fsgsssgntasltitgaqaedeadyycnsrdssgnhwvfgggteltvlgqpkaapsvtlf
ppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaassyl
sltpeqwkshrsyscqvthegstvektvaptecs

    Sequence, based on observed residues (ATOM records):
    >6erxR (R:)
seltqdpavsvalgqtvrvtcqgdslrsyyaswyqqkpgqapvlviygknnrpsgipdrf
sgsssgntasltitgaqaedeadyycnsrdssgnhwvfgggteltvlgqpkaapsvtlfp
psseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaassyls
ltpeqwkshrsyscqvthegstvektvap