PDB entry 6erp

View 6erp on RCSB PDB site
Description: structure of the human mitochondrial transcription initiation complex at the lsp promoter
Deposited on 2017-10-18, released 2017-11-15
The last revision was dated 2018-01-31, with a file datestamp of 2018-01-26.
Experiment type: XRAY
Resolution: 4.5 Å
R-factor: N/A
AEROSPACI score: 0.04 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: DNA-directed RNA polymerase, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: POLRMT
    Database cross-references and differences (RAF-indexed):
    • Uniprot O00411 (Start-1127)
      • engineered mutation (452)
  • Chain 'B':
    Compound: DNA-directed RNA polymerase, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: POLRMT
    Database cross-references and differences (RAF-indexed):
    • Uniprot O00411 (Start-1127)
      • engineered mutation (452)
  • Chain 'C':
    Compound: Transcription factor A, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: TFAM, TCF6, TCF6L2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q00059 (2-End)
      • conflict (8)
  • Chain 'D':
    Compound: non-template DNA
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
  • Chain 'E':
    Compound: Template DNA
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
  • Chain 'F':
    Compound: Dimethyladenosine transferase 2, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: TFB2M, NS5ATP5
    Database cross-references and differences (RAF-indexed):
  • Chain 'G':
    Compound: Transcription factor A, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: TFAM, TCF6, TCF6L2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q00059 (2-End)
      • conflict (8)
  • Chain 'H':
    Compound: non-template DNA
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
  • Chain 'I':
    Compound: Template DNA
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
  • Chain 'J':
    Compound: Dimethyladenosine transferase 2, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: TFB2M, NS5ATP5
    Database cross-references and differences (RAF-indexed):

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6erpA (A:)
narkvqmgakdatpvpcgrwakilekdkrtqqmrmqrlkaklqmpfqsgefkaltrrlqv
eprllskqmagcledctrqapespweeqlarllqeapgklsldveqapsgqhsqaqlsgq
qqrllaffkcclltdqlplahhllvvhhgqrqkrklltldmynavmlgwarqgafkelvy
vlfmvkdagltpdllsyaaalqcmgrqdqdagtiercleqmsqeglklqalftavllsee
dratvlkavhkvkptfslppqlpppvntskllrdvyakdgrvsypklhlplktlqclfek
qlhmelasrvcvvsvekptlpskevkharktlktlrdqwekalcralretknrlerevye
grfslypflcllderevvrmllqvlqalpaqgesfttlarelsartfsrhvvqrqrvsgq
vqalqnhyrkylcllasdaevpepclprqywealgapealreqpwplpvqmelgkllaem
lvqatqmpcsldkphrssrlvpvlyhvysfrnvqqigilkphpayvqllekaaeptltfe
avdvpmlcpplpwtsphsgafllsptklmrtvegatqhqelletcpptalhgaldaltql
gncawrvngrvldlvlqlfqakgcpqlgvpappseapqppeahlphsaaparkaelrrel
ahcqkvaremhslraealyrlslaqhlrdrvfwlphnmdfrgrtypcpphfnhlgsdvar
allefaqgrplgphgldwlkihlvnltglkkreplrkrlafaeevmddildsadqpltgr
kwwmgaeepwqtlaccmevanavrasdpaayvshlpvhqdgscnglqhyaalgrdsvgaa
svnlepsdvpqdvysgvaaqvevfrrqdaqrgmrvaqvlegfitrkvvkqtvmtvvygvt
ryggrlqiekrlrelsdfpqefvweashylvrqvfkslqemfsgtraiqhwltesarlis
hmgsvvewvtplgvpviqpyrldskvkqigggiqsitythngdisrkpntrkqkngfppn
fihsldsshmmltalhcyrkgltfvsvhdcywthaadvsvmnqvcreqfvrlhsepilqd
lsrflvkrfcsepqkileasqlketlqavpkpgafdleqvkrstyffs

    Sequence, based on observed residues (ATOM records):
    >6erpA (A:)
wakilekdkrtqqmrmqrlkaklqmqlsgqqqrllaffkcclltdqlplahhllvvhhgq
rqkrklltldmynavmlgwarqgafkelvyvlfmvkdagltpdllsyaaalqcmgrqdqd
agtiercleqmsqeglklqalftavllseedratvlkavhkvkptfslppqlpppvntsk
llrdvyakdgrvsypklhlplktlqclfekqlhmelasrvcvvsvekptlpskevkhark
tlktlrdqwekalcralretknrlerevyegrfslypflcllderevvrmllqvlqalpa
qgesfttlarelsartfsrhvvqrqrvsgqvqalqnhyrkylcllasdaevpepclprqy
wealgapealreqpwplpvqmelgkllaemlvqatqmpcsldrssrlvpvlyhvysfrnv
qqigilkphpayvqllekaaeptltfeavdvpmlcpplpwtsphsgafllsptklmrtve
gatqhqelletcpptalhgaldaltqlgncawrvngrvldlvlqlfqakgcpqlgvpapp
seapelahcqkvaremhslraealyrlslaqhlrdrvfwlphnmdfrgrtypcpphfnhl
gsdvarallefaqgrplgphgldwlkihlvnltglkkreplrkrlafaeevmddildsad
qpltgrkwwmgaeepwqtlaccmevanavrasdpaayvshlpvhqdgscnglqhyaalgr
dsvgaasvnlepsdvpqdvysgvaaqvevfrrqdaqrgmrvaqvlegfitrkvvkqtvmt
vvygvtryggrlqiekrlrelsdfpqefvweashylvrqvfkslqemfsgtraiqhwlte
sarlishmgsvvewvtplgvpviqpyrldskvkqiggsitythngdisrkpntrkqkngf
ppnfihsldsshmmltalhcyrkgltfvsvhdcywthaadvsvmnqvcreqfvrlhsepi
lqdlsrflvkrfcsepqkileasqlketlqavpkpgafdleqvkrstyffs

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6erpB (B:)
narkvqmgakdatpvpcgrwakilekdkrtqqmrmqrlkaklqmpfqsgefkaltrrlqv
eprllskqmagcledctrqapespweeqlarllqeapgklsldveqapsgqhsqaqlsgq
qqrllaffkcclltdqlplahhllvvhhgqrqkrklltldmynavmlgwarqgafkelvy
vlfmvkdagltpdllsyaaalqcmgrqdqdagtiercleqmsqeglklqalftavllsee
dratvlkavhkvkptfslppqlpppvntskllrdvyakdgrvsypklhlplktlqclfek
qlhmelasrvcvvsvekptlpskevkharktlktlrdqwekalcralretknrlerevye
grfslypflcllderevvrmllqvlqalpaqgesfttlarelsartfsrhvvqrqrvsgq
vqalqnhyrkylcllasdaevpepclprqywealgapealreqpwplpvqmelgkllaem
lvqatqmpcsldkphrssrlvpvlyhvysfrnvqqigilkphpayvqllekaaeptltfe
avdvpmlcpplpwtsphsgafllsptklmrtvegatqhqelletcpptalhgaldaltql
gncawrvngrvldlvlqlfqakgcpqlgvpappseapqppeahlphsaaparkaelrrel
ahcqkvaremhslraealyrlslaqhlrdrvfwlphnmdfrgrtypcpphfnhlgsdvar
allefaqgrplgphgldwlkihlvnltglkkreplrkrlafaeevmddildsadqpltgr
kwwmgaeepwqtlaccmevanavrasdpaayvshlpvhqdgscnglqhyaalgrdsvgaa
svnlepsdvpqdvysgvaaqvevfrrqdaqrgmrvaqvlegfitrkvvkqtvmtvvygvt
ryggrlqiekrlrelsdfpqefvweashylvrqvfkslqemfsgtraiqhwltesarlis
hmgsvvewvtplgvpviqpyrldskvkqigggiqsitythngdisrkpntrkqkngfppn
fihsldsshmmltalhcyrkgltfvsvhdcywthaadvsvmnqvcreqfvrlhsepilqd
lsrflvkrfcsepqkileasqlketlqavpkpgafdleqvkrstyffs

    Sequence, based on observed residues (ATOM records):
    >6erpB (B:)
wakilekdkrtqqmrmqrlkaklqmqlsgqqqrllaffkcclltdqlplahhllvvhhgq
rqkrklltldmynavmlgwarqgafkelvyvlfmvkdagltpdllsyaaalqcmgrqdqd
agtiercleqmsqeglklqalftavllseedratvlkavhkvkptfslppqlpppvntsk
llrdvyakdgrvsypklhlplktlqclfekqlhmelasrvcvvsvekptlpskevkhark
tlktlrdqwekalcralretknrlerevyegrfslypflcllderevvrmllqvlqalpa
qgesfttlarelsartfsrhvvqrqrvsgqvqalqnhyrkylcllasdaevpepclprqy
wealgapealreqpwplpvqmelgkllaemlvqatqmpcsldrssrlvpvlyhvysfrnv
qqigilkphpayvqllekaaeptltfeavdvpmlcpplpwtsphsgafllsptklmrtat
qhqelletcpptalhgaldaltqlgncawrvngrvldlvlqlfqakgcpqlgvpappseh
cqkvaremhslraealyrlslaqhlrdrvfwlphnmdfrgrtypcpphfnhlgsdvaral
lefaqgrplgphgldwlkihlvnltglkkreplrkrlafaeevmddildsadqpltgrkw
wmgaeepwqtlaccmevanavrasdpaayvshlpvhqdgscnglqhyaalgrdsvgaasv
nlepsdvpqdvysgvaaqvevfrrqdaqrgmrvaqvlegfitrkvvkqtvmtvvygvtry
ggrlqiekrlrelsdfpqefvweashylvrqvfkslqemfsgtraiqhwltesarlishm
gsvvewvtplgvpviqpyrldskvkqiggsitythngdisrkpntrkqkngfppnfihsl
dsshmmltalhcyrkgltfvsvhdcywthaadvsvmnqvcreqfvrlhsepilqdlsrfl
vkrfcsepqkileasqlketlqavpkpgafdleqvkrstyffs

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6erpC (C:)
nassvlasspkkpvssylrfskeqlpifkaqnpdakttelirriaqrwrelpdskkkiyq
dayraewqvykeeisrfkeqltpsqimslekeimdkhlkrkamtkkkeltllgkpkrprs
aynvyvaerfqeakgdspqeklktvkenwknlsdsekelyiqhakedetryhnemkswee
qmievgrkdllrrtikkqrkygaee

    Sequence, based on observed residues (ATOM records):
    >6erpC (C:)
ssvlasspkkpvssylrfskeqlpifkaqnpdakttelirriaqrwrelpdskkkiyqda
yraewqvykeeisrfkeqltpsqimslekeimdkhlkrkamtkkkeltllgkpkrprsay
nvyvaerfqeakgdspqeklktvkenwknlsdsekelyiqhakedetryhnemksweeqm
ievgrkdllrrt

  • Chain 'D':
    No sequence available.

  • Chain 'E':
    No sequence available.

  • Chain 'F':
    Sequence, based on SEQRES records:
    >6erpF (F:)
narfcilgseaatrkhlparnhcglsdsspqlwpepdfrnpprkaskasldfkryvtdrr
laetlaqiylgkpsrpphlllecnpgpgiltqalleagakvvalesdktfiphleslgkn
ldgklrvihcdffkldprsggvikppamssrglfknlgieavpwtadiplkvvgmfpsrg
ekralwklaydlysctsiykfgrievnmfigekefqklmadpgnpdlyhvlsviwqlace
ikvlhmepwssfdiytrkgplenpkrrelldqlqqklyliqmiprqnlftknltpmnyni
ffhllkhcfgrrsatvidhlrsltpldardilmqigkqedekvvnmhpqdfktlfetier
skdcaykwlydetledr

    Sequence, based on observed residues (ATOM records):
    >6erpF (F:)
kryvtdrrlaetlaqiylghlllecnpgpgiltqalleagakvvalesdktfiphleslg
knldgklrvihcdffkldprsggvikppamssrglfknlgieavpwtadiplkvvgmfps
rgekralwklaydlysctsiykfgrievnmfigekefqklmadpgnpdlyhvlsviwqla
ceikvlhmepklyliqmiprqnlftknltpmnyniffhllkhcfgrrsatvidhlrsltp
ldardilmqigkqedekvvnmhpqdfktlfetierskdcaykwlydet

  • Chain 'G':
    Sequence, based on SEQRES records:
    >6erpG (G:)
nassvlasspkkpvssylrfskeqlpifkaqnpdakttelirriaqrwrelpdskkkiyq
dayraewqvykeeisrfkeqltpsqimslekeimdkhlkrkamtkkkeltllgkpkrprs
aynvyvaerfqeakgdspqeklktvkenwknlsdsekelyiqhakedetryhnemkswee
qmievgrkdllrrtikkqrkygaee

    Sequence, based on observed residues (ATOM records):
    >6erpG (G:)
ssvlasspkkpvssylrfskeqlpifkaqnpdakttelirriaqrwrelpdskkkiyqda
yraewqvykeeisrfkeqltpsqimslekeimdkhlkrkamtkkkeltllgkpkrprsay
nvyvaerfqeakgdspqeklktvkenwknlsdsekelyiqhakedetryhnemksweeqm
ievgrkdllrrt

  • Chain 'H':
    No sequence available.

  • Chain 'I':
    No sequence available.

  • Chain 'J':
    Sequence, based on SEQRES records:
    >6erpJ (J:)
narfcilgseaatrkhlparnhcglsdsspqlwpepdfrnpprkaskasldfkryvtdrr
laetlaqiylgkpsrpphlllecnpgpgiltqalleagakvvalesdktfiphleslgkn
ldgklrvihcdffkldprsggvikppamssrglfknlgieavpwtadiplkvvgmfpsrg
ekralwklaydlysctsiykfgrievnmfigekefqklmadpgnpdlyhvlsviwqlace
ikvlhmepwssfdiytrkgplenpkrrelldqlqqklyliqmiprqnlftknltpmnyni
ffhllkhcfgrrsatvidhlrsltpldardilmqigkqedekvvnmhpqdfktlfetier
skdcaykwlydetledr

    Sequence, based on observed residues (ATOM records):
    >6erpJ (J:)
kryvtdrrlaetlaqiylghlllecnpgpgiltqalleagakvvalesdktfiphleslg
knldgklrvihcdffkldprsggvikppamssrglfknlgieavpwtadiplkvvgmfps
rgekralwklaydlysctsiykfgrievnmfigekefqklmadpgnpdlyhvlsviwqla
ceikvlhmepklyliqmiprqnlftknltpmnyniffhllkhcfgrrsatvidhlrsltp
ldardilmqigkqedekvvnmhpqdfktlfetierskdcaykwlydet