PDB entry 6eqw

View 6eqw on RCSB PDB site
Description: x-ray structure of the proprotein convertase furin bound with the competitive inhibitor 4-aminomethyl-phenylacetyl-arg-val-arg-amba
Deposited on 2017-10-16, released 2018-02-28
The last revision was dated 2018-02-28, with a file datestamp of 2018-02-23.
Experiment type: XRAY
Resolution: 1.99 Å
R-factor: N/A
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Furin
    Species: Homo sapiens [TaxId:9606]
    Gene: FURIN, FUR, PACE, PCSK3
    Database cross-references and differences (RAF-indexed):
    • Uniprot P09958 (Start-466)
      • expression tag (467-473)
  • Chain 'D':
    Compound: ama-arg-tbg-arg-00s
    Species: synthetic construct, synthetic [TaxId:32630]
    Database cross-references and differences (RAF-indexed):
    • PDB 6EQW (0-4)
  • Heterogens: CA, NA, CL, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6eqwA (A:)
dvyqeptdpkfpqqwylsgvtqrdlnvkaawaqgytghgivvsilddgieknhpdlagny
dpgasfdvndqdpdpqprytqmndnrhgtrcagevaavanngvcgvgvaynariggvrml
dgevtdavearslglnpnhihiysaswgpeddgktvdgparlaeeaffrgvsqgrgglgs
ifvwasgnggrehdscncdgytnsiytlsissatqfgnvpwyseacsstlattyssgnqn
ekqivttdlrqkcteshtgtsasaplaagiialtleanknltwrdmqhlvvqtskpahln
andwatngvgrkvshsygyglldagamvalaqnwttvapqrkciidiltepkdigkrlev
rktvtaclgepnhitrlehaqarltlsynrrgdlaihlvspmgtrstllaarphdysadg
fndwafmtthswdedpsgewvleientseannygtltkftlvlygtasgslvprgshhhh
hh

    Sequence, based on observed residues (ATOM records):
    >6eqwA (A:)
vyqeptdpkfpqqwylsgvtqrdlnvkaawaqgytghgivvsilddgieknhpdlagnyd
pgasfdvndqdpdpqprytqmndnrhgtrcagevaavanngvcgvgvaynariggvrmld
gevtdavearslglnpnhihiysaswgpeddgktvdgparlaeeaffrgvsqgrgglgsi
fvwasgnggrehdscncdgytnsiytlsissatqfgnvpwyseacsstlattyssgnqne
kqivttdlrqkcteshtgtsasaplaagiialtleanknltwrdmqhlvvqtskpahlna
ndwatngvgrkvshsygyglldagamvalaqnwttvapqrkciidiltepkdigkrlevr
ktvtaclgepnhitrlehaqarltlsynrrgdlaihlvspmgtrstllaarphdysadgf
ndwafmtthswdedpsgewvleientseannygtltkftlvlygtasgslvpr

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records:
    >6eqwD (D:)
xrgrx