PDB entry 6epp

View 6epp on RCSB PDB site
Description: ras guanine exchange factor sos1 (rem-cdc25) in complex with kras(g12c) and fragment screening hit f4
Class: signaling protein
Keywords: Guanine nucleotide exchange factor, GEF, Fragment Screen, GTPASE, SIGNALING PROTEIN
Deposited on 2017-10-12, released 2019-02-06
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-08-14, with a file datestamp of 2019-08-09.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: N/A
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'R':
    Compound: GTPase KRas
    Species: Homo sapiens [TaxId:9606]
    Gene: KRAS, KRAS2, RASK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01116 (1-End)
      • engineered mutation (12)
      • engineered mutation (118)
      • engineered mutation (126-128)
    Domains in SCOPe 2.08: d6eppr_
  • Chain 'S':
    Compound: Son of sevenless homolog 1
    Species: Homo sapiens [TaxId:9606]
    Gene: SOS1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6epps_
  • Heterogens: BOQ, GOL, HOH

PDB Chain Sequences:

  • Chain 'R':
    Sequence, based on SEQRES records: (download) 
    >6eppR (R:)
gmteyklvvvgacgvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldildta
gqeeysamrdqymrtgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgnksd
lpsrtvesrqaqdlarsygipfietsaktrqgvddafytlvreirkhkek

    Sequence, based on observed residues (ATOM records): (download) 
    >6eppR (R:)
mteyklvvvgacgvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldildtag
qeeysamrdqymrtgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgnksdl
psrtvesrqaqdlarsygipfietsaktrqgvddafytlvreirkhke

  • Chain 'S':
    Sequence, based on SEQRES records: (download) 
    >6eppS (S:)
geeqmrlpsadvyrfaepdseeniifeenmqpkagipiikagtviklierltyhmyadpn
fvrtflttyrsfckpqellsliierfeipepepteadriaiengdqplsaelkrfrkeyi
qpvqlrvlnvcrhwvehhfydferdayllqrmeefigtvrgkamkkwvesitkiiqrkki
ardngpghnitfqsspptvewhisrpghietfdlltlhpieiarqltllesdlyravqps
elvgsvwtkedkeinspnllkmirhttnltlwfekcivetenleervavvsriieilqvf
qelnnfngvlevvsamnsspvyrldhtfeqipsrqkkileeahelsedhykkylaklrsi
nppcvpffgiyltnilkteegnpevlkrhgkelinfskrrkvaeitgeiqqyqnqpyclr
vesdikrffenlnpmgnsmekeftdylfnksleieprnpkplprfpkkysyplkspgvrp
snprpgt

    Sequence, based on observed residues (ATOM records): (download) 
    >6eppS (S:)
eqmrlpsadvyrfaepdseeniifeenmqpkagipiikagtviklierltyhmyadpnfv
rtflttyrsfckpqellsliierfeipepepsaelkrfrkeyiqpvqlrvlnvcrhwveh
hfydferdayllqrmeefigtvrgkamkkwvesitkiiqrkkiaitfqsspptvewhisr
pghietfdlltlhpieiarqltllesdlyravqpselvgsvwtkedkeinspnllkmirh
ttnltlwfekcivetenleervavvsriieilqvfqelnnfngvlevvsamnsspvyrld
htfeqipsrqkkileeahelsedhykkylaklrsinppcvpffgiyltnilkteegnpev
lkrhgkelinfskrrkvaeitgeiqqyqnqpyclrvesdikrffenlnpmgnsmekeftd
ylfnksleieprnpkplprfpkkysyplkspgvrpsnpr