PDB entry 6epm

View 6epm on RCSB PDB site
Description: Ras guanine nucleotide exchange factor SOS1 (Rem-cdc25) in complex with KRAS(G12C) and fragment screening hit F1
Class: signaling protein
Keywords: Guanine nucleotide exchange factor, GEF, Fragment Screen, GTPASE, SIGNALING PROTEIN
Deposited on 2017-10-12, released 2019-02-06
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-02-20, with a file datestamp of 2019-02-15.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: N/A
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'R':
    Compound: GTPase KRas
    Species: Homo sapiens [TaxId:9606]
    Gene: KRAS, KRAS2, RASK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01116 (1-169)
      • engineered mutation (12)
      • engineered mutation (118)
      • engineered mutation (126-128)
    Domains in SCOPe 2.08: d6epmr_
  • Chain 'S':
    Compound: Son of sevenless homolog 1
    Species: Homo sapiens [TaxId:9606]
    Gene: SOS1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6epms_
  • Heterogens: BQ5, GOL, HOH

PDB Chain Sequences:

  • Chain 'R':
    Sequence, based on SEQRES records: (download) 
    >6epmR (R:)
gmteyklvvvgacgvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldildta
gqeeysamrdqymrtgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgnksd
lpsrtvesrqaqdlarsygipfietsaktrqgvddafytlvreirkhkek

    Sequence, based on observed residues (ATOM records): (download) 
    >6epmR (R:)
mteyklvvvgacgvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldildtag
qeeysamrdqymrtgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgnksdl
psrtvesrqaqdlarsygipfietsaktrqgvddafytlvreirkhkek

  • Chain 'S':
    Sequence, based on SEQRES records: (download) 
    >6epmS (S:)
geeqmrlpsadvyrfaepdseeniifeenmqpkagipiikagtviklierltyhmyadpn
fvrtflttyrsfckpqellsliierfeipepepteadriaiengdqplsaelkrfrkeyi
qpvqlrvlnvcrhwvehhfydferdayllqrmeefigtvrgkamkkwvesitkiiqrkki
ardngpghnitfqsspptvewhisrpghietfdlltlhpieiarqltllesdlyravqps
elvgsvwtkedkeinspnllkmirhttnltlwfekcivetenleervavvsriieilqvf
qelnnfngvlevvsamnsspvyrldhtfeqipsrqkkileeahelsedhykkylaklrsi
nppcvpffgiyltnilkteegnpevlkrhgkelinfskrrkvaeitgeiqqyqnqpyclr
vesdikrffenlnpmgnsmekeftdylfnksleieprnpkplprfpkkysyplkspgvrp
snprpgt

    Sequence, based on observed residues (ATOM records): (download) 
    >6epmS (S:)
eqmrlpsadvyrfaepdseeniifeenmqpkagipiikagtviklierltyhmyadpnfv
rtflttyrsfckpqellsliierfeipepepteasaelkrfrkeyiqpvqlrvlnvcrhw
vehhfydferdayllqrmeefigtvrgkamkkwvesitkiiqrkkiaitfqsspptvewh
isrpghietfdlltlhpieiarqltllesdlyravqpselvgsvwtkedkeinspnllkm
irhttnltlwfekcivetenleervavvsriieilqvfqelnnfngvlevvsamnsspvy
rldhtfeqipsrqkkileeahelsedhykkylaklrsinppcvpffgiyltnilkteegn
pevlkrhgkelinfskrrkvaeitgeiqqyqnqpyclrvesdikrffenlnpmgnsmeke
ftdylfnksleieprnpkplprfpkkysyplkspgvrpsnpr