PDB entry 6enm

View 6enm on RCSB PDB site
Description: Crystal structure of MMP12 in complex with hydroxamate inhibitor LP168.
Class: hydrolase
Keywords: metzincin, carboxylate inhibitor alternative zinc-binding groups, HYDROLASE
Deposited on 2017-10-05, released 2018-05-16
The last revision prior to the SCOPe 2.07 freeze date was dated 2018-05-16, with a file datestamp of 2018-05-11.
Experiment type: XRAY
Resolution: 1.59 Å
R-factor: N/A
AEROSPACI score: 0.44 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Macrophage metalloelastase
    Species: Homo sapiens [TaxId:9606]
    Gene: MMP12, HME
    Database cross-references and differences (RAF-indexed):
    • Uniprot P39900 (Start-158)
      • engineered mutation (66)
    Domains in SCOPe 2.07: d6enma_
  • Chain 'B':
    Compound: Macrophage metalloelastase
    Species: Homo sapiens [TaxId:9606]
    Gene: MMP12, HME
    Database cross-references and differences (RAF-indexed):
    • Uniprot P39900 (Start-158)
      • engineered mutation (66)
    Domains in SCOPe 2.07: d6enmb_
  • Heterogens: LPW, ZN, CA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >6enmA (A:)
    mgpvwrkhyityrinnytpdmnredvdyairkafqvwsnvtplkfskintgmadilvvfa
    rgahgddhafdgkggilahafgpgsgiggdahfdedefwtthsggtnlfltavheighsl
    glghssdpkavmfptykyvdintfrlsaddirgiqslyg
    

    Sequence, based on observed residues (ATOM records): (download)
    >6enmA (A:)
    hyityrinnytpdmnredvdyairkafqvwsnvtplkfskintgmadilvvfargahgdd
    hafdgkggilahafgpgsgiggdahfdedefwtthsggtnlfltavheighslglghssd
    pkavmfptykyvdintfrlsaddirgiqslyg
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >6enmB (B:)
    mgpvwrkhyityrinnytpdmnredvdyairkafqvwsnvtplkfskintgmadilvvfa
    rgahgddhafdgkggilahafgpgsgiggdahfdedefwtthsggtnlfltavheighsl
    glghssdpkavmfptykyvdintfrlsaddirgiqslyg
    

    Sequence, based on observed residues (ATOM records): (download)
    >6enmB (B:)
    hyityrinnytpdmnredvdyairkafqvwsnvtplkfskintgmadilvvfargahgdd
    hafdgkggilahafgpgsgiggdahfdedefwtthsggtnlfltavheighslglghssd
    pkavmfptykyvdintfrlsaddirgiqslyg