SCOPe 2.08: Structural Classification of Proteins

PDB entry 6en6

View 6en6 on RCSB PDB site
Description: Crystal structure B of the Angiotensin-1 converting enzyme N-domain in complex with a diprolyl inhibitor.
Class: hydrolase
Keywords: ACE inhibitor, Angiotensin-I converting enzyme, Diprolyl inhibitor, HYDROLASE
Deposited on 2017-10-04, released 2018-03-07
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-06-29.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: N/A
AEROSPACI score: 0.47 (click here for full SPACI score report)

Chains and heterogens:

Chain 'A':
Compound: angiotensin-converting enzyme
Species: Homo sapiens [TaxId:9606]
Gene: ACE, DCP, DCP1
Database cross-references and differences (RAF-indexed):
- Uniprot P12821 (0-End)
  - conflict (8)
  - conflict (24)
  - conflict (81)
  - conflict (116)
  - conflict (288)
  - conflict (544)
  - conflict (575)
Domains in SCOPe 2.08: d6en6a_
Chain 'B':
Compound: angiotensin-converting enzyme
Species: Homo sapiens [TaxId:9606]
Gene: ACE, DCP, DCP1
Database cross-references and differences (RAF-indexed):
- Uniprot P12821 (0-End)
  - conflict (8)
  - conflict (24)
  - conflict (81)
  - conflict (116)
  - conflict (288)
  - conflict (544)
  - conflict (575)
Domains in SCOPe 2.08: d6en6b_
Chain 'C':
Compound: angiotensin-converting enzyme
Species: Homo sapiens [TaxId:9606]
Gene: ACE, DCP, DCP1
Database cross-references and differences (RAF-indexed):
- Uniprot P12821 (0-End)
  - conflict (8)
  - conflict (24)
  - conflict (81)
  - conflict (116)
  - conflict (288)
  - conflict (544)
  - conflict (575)
Domains in SCOPe 2.08: d6en6c_
Chain 'D':
Compound: angiotensin-converting enzyme
Species: Homo sapiens [TaxId:9606]
Gene: ACE, DCP, DCP1
Database cross-references and differences (RAF-indexed):
- Uniprot P12821 (0-End)
  - conflict (8)
  - conflict (24)
  - conflict (81)
  - conflict (116)
  - conflict (130)
  - conflict (288)
  - conflict (544)
  - conflict (575)
Domains in SCOPe 2.08: d6en6d_
Heterogens: ZN, BJ2, CL, MG, PEG, EDO, ACT, PGE, BCN, 2PE, XPE, NAG, HOH

PDB Chain Sequences:

Chain 'A':
Sequence, based on SEQRES records: (download)

>6en6A (A:)
ldpglqpgqfsadeagaqlfaqsyqssaeqvlfqsvaaswahdtnitaenarrqeeaall
sqefaeawgqkakelyepiwqqftdpqlrriigavrtlgsanlplakrqqynallsqmsr
iystakvclpqktatcwsldpdltnilassrsyamllfawegwhnaagiplkplyedfta
lsneaykqdgftdtgaywrswynsptfeddlehlyqqleplylnlhafvrralhrrygdr
yinlrgpipahllgdmwaqsweniydmvvpfpdkpnldvtstmlqqgwqathmfrvaeef
ftslelspmppefwegsmlekpadgrevvchasawdfynrkdfrikqctrvtmdqlstvh
hemghiqyylqykdlpvslrrganpgfheaigdvlalsvstpehlhkiglldrvtndtes
dinyllkmalekiaflpfgylvdqwrwgvfsgrtppsrynfdwwylrtkyqgicppvtrn
ethfdagakfhvpnvtpyiryfvsfvlqfqfhealckeagyegplhqcdiyrstkagakl
rkvlragssrpwqevlkdmvgldaldaqpllkyfqlvtqwlqeqnqqngevlgwpeyqwh
pplpdnypegidlvtdeaeaskfveeydl

Sequence, based on observed residues (ATOM records): (download)

>6en6A (A:)
ldpglqpgqfsadeagaqlfaqsyqssaeqvlfqsvaaswahdtnitaenarrqeeaall
sqefaeawgqkakelyepiwqqftdpqlrriigavrtlgsanlplakrqqynallsqmsr
iystakvclpcwsldpdltnilassrsyamllfawegwhnaagiplkplyedftalsnea
ykqdgftdtgaywrswynsptfeddlehlyqqleplylnlhafvrralhrrygdryinlr
gpipahllgdmwaqsweniydmvvpfpdkpnldvtstmlqqgwqathmfrvaeefftsle
lspmppefwegsmlekpadgrevvchasawdfynrkdfrikqctrvtmdqlstvhhemgh
iqyylqykdlpvslrrganpgfheaigdvlalsvstpehlhkiglldrvtndtesdinyl
lkmalekiaflpfgylvdqwrwgvfsgrtppsrynfdwwylrtkyqgicppvtrnethfd
agakfhvpnvtpyiryfvsfvlqfqfhealckeagyegplhqcdiyrstkagaklrkvlr
agssrpwqevlkdmvgldaldaqpllkyfqlvtqwlqeqnqqngevlgwpeyqwhpplpd
nypeg

Chain 'B':
Sequence, based on SEQRES records: (download)

>6en6B (B:)
ldpglqpgqfsadeagaqlfaqsyqssaeqvlfqsvaaswahdtnitaenarrqeeaall
sqefaeawgqkakelyepiwqqftdpqlrriigavrtlgsanlplakrqqynallsqmsr
iystakvclpqktatcwsldpdltnilassrsyamllfawegwhnaagiplkplyedfta
lsneaykqdgftdtgaywrswynsptfeddlehlyqqleplylnlhafvrralhrrygdr
yinlrgpipahllgdmwaqsweniydmvvpfpdkpnldvtstmlqqgwqathmfrvaeef
ftslelspmppefwegsmlekpadgrevvchasawdfynrkdfrikqctrvtmdqlstvh
hemghiqyylqykdlpvslrrganpgfheaigdvlalsvstpehlhkiglldrvtndtes
dinyllkmalekiaflpfgylvdqwrwgvfsgrtppsrynfdwwylrtkyqgicppvtrn
ethfdagakfhvpnvtpyiryfvsfvlqfqfhealckeagyegplhqcdiyrstkagakl
rkvlragssrpwqevlkdmvgldaldaqpllkyfqlvtqwlqeqnqqngevlgwpeyqwh
pplpdnypegidlvtdeaeaskfveeydl

Sequence, based on observed residues (ATOM records): (download)

>6en6B (B:)
ldpglqpgqfsadeagaqlfaqsyqssaeqvlfqsvaaswahdtnitaenarrqeeaall
sqefaeawgqkakelyepiwqqftdpqlrriigavrtlgsanlplakrqqynallsqmsr
iystakvclcwsldpdltnilassrsyamllfawegwhnaagiplkplyedftalsneay
kqdgftdtgaywrswynsptfeddlehlyqqleplylnlhafvrralhrrygdryinlrg
pipahllgdmwaqsweniydmvvpfpdkpnldvtstmlqqgwqathmfrvaeefftslel
spmppefwegsmlekpadgrevvchasawdfynrkdfrikqctrvtmdqlstvhhemghi
qyylqykdlpvslrrganpgfheaigdvlalsvstpehlhkiglldrvtndtesdinyll
kmalekiaflpfgylvdqwrwgvfsgrtppsrynfdwwylrtkyqgicppvtrnethfda
gakfhvpnvtpyiryfvsfvlqfqfhealckeagyegplhqcdiyrstkagaklrkvlra
gssrpwqevlkdmvgldaldaqpllkyfqlvtqwlqeqnqqngevlgwpeyqwhpplpdn
ypegi

Chain 'C':
Sequence, based on SEQRES records: (download)

>6en6C (C:)
ldpglqpgqfsadeagaqlfaqsyqssaeqvlfqsvaaswahdtnitaenarrqeeaall
sqefaeawgqkakelyepiwqqftdpqlrriigavrtlgsanlplakrqqynallsqmsr
iystakvclpqktatcwsldpdltnilassrsyamllfawegwhnaagiplkplyedfta
lsneaykqdgftdtgaywrswynsptfeddlehlyqqleplylnlhafvrralhrrygdr
yinlrgpipahllgdmwaqsweniydmvvpfpdkpnldvtstmlqqgwqathmfrvaeef
ftslelspmppefwegsmlekpadgrevvchasawdfynrkdfrikqctrvtmdqlstvh
hemghiqyylqykdlpvslrrganpgfheaigdvlalsvstpehlhkiglldrvtndtes
dinyllkmalekiaflpfgylvdqwrwgvfsgrtppsrynfdwwylrtkyqgicppvtrn
ethfdagakfhvpnvtpyiryfvsfvlqfqfhealckeagyegplhqcdiyrstkagakl
rkvlragssrpwqevlkdmvgldaldaqpllkyfqlvtqwlqeqnqqngevlgwpeyqwh
pplpdnypegidlvtdeaeaskfveeydl

Sequence, based on observed residues (ATOM records): (download)

>6en6C (C:)
ldpglqpgqfsadeagaqlfaqsyqssaeqvlfqsvaaswahdtnitaenarrqeeaall
sqefaeawgqkakelyepiwqqftdpqlrriigavrtlgsanlplakrqqynallsqmsr
iystakvclptcwsldpdltnilassrsyamllfawegwhnaagiplkplyedftalsne
aykqdgftdtgaywrswynsptfeddlehlyqqleplylnlhafvrralhrrygdryinl
rgpipahllgdmwaqsweniydmvvpfpdkpnldvtstmlqqgwqathmfrvaeefftsl
elspmppefwegsmlekpadgrevvchasawdfynrkdfrikqctrvtmdqlstvhhemg
hiqyylqykdlpvslrrganpgfheaigdvlalsvstpehlhkiglldrvtndtesdiny
llkmalekiaflpfgylvdqwrwgvfsgrtppsrynfdwwylrtkyqgicppvtrnethf
dagakfhvpnvtpyiryfvsfvlqfqfhealckeagyegplhqcdiyrstkagaklrkvl
ragssrpwqevlkdmvgldaldaqpllkyfqlvtqwlqeqnqqngevlgwpeyqwhpplp
dnypeg

Chain 'D':
Sequence, based on SEQRES records: (download)

>6en6D (D:)
ldpglqpgqfsadeagaqlfaqsyqssaeqvlfqsvaaswahdtnitaenarrqeeaall
sqefaeawgqkakelyepiwqqftdpqlrriigavrtlgsanlplakrqqynallsqmsr
iystakvclpqktatcwsldpdltnilassrsyamllfawegwhnaagiplkplyedfta
lsneaykqdgftdtgaywrswynsptfeddlehlyqqleplylnlhafvrralhrrygdr
yinlrgpipahllgdmwaqsweniydmvvpfpdkpnldvtstmlqqgwqathmfrvaeef
ftslelspmppefwegsmlekpadgrevvchasawdfynrkdfrikqctrvtmdqlstvh
hemghiqyylqykdlpvslrrganpgfheaigdvlalsvstpehlhkiglldrvtndtes
dinyllkmalekiaflpfgylvdqwrwgvfsgrtppsrynfdwwylrtkyqgicppvtrn
ethfdagakfhvpnvtpyiryfvsfvlqfqfhealckeagyegplhqcdiyrstkagakl
rkvlragssrpwqevlkdmvgldaldaqpllkyfqlvtqwlqeqnqqngevlgwpeyqwh
pplpdnypegidlvtdeaeaskfveeydl

Sequence, based on observed residues (ATOM records): (download)

>6en6D (D:)
ldpglqpgqfsadeagaqlfaqsyqssaeqvlfqsvaaswahdtnitaenarrqeeaall
sqefaeawgqkakelyepiwqqftdpqlrriigavrtlgsanlplakrqqynallsqmsr
iystakvclpqcwsldpdltnilassrsyamllfawegwhnaagiplkplyedftalsne
aykqdgftdtgaywrswynsptfeddlehlyqqleplylnlhafvrralhrrygdryinl
rgpipahllgdmwaqsweniydmvvpfpdkpnldvtstmlqqgwqathmfrvaeefftsl
elspmppefwegsmlekpadgrevvchasawdfynrkdfrikqctrvtmdqlstvhhemg
hiqyylqykdlpvslrrganpgfheaigdvlalsvstpehlhkiglldrvtndtesdiny
llkmalekiaflpfgylvdqwrwgvfsgrtppsrynfdwwylrtkyqgicppvtrnethf
dagakfhvpnvtpyiryfvsfvlqfqfhealckeagyegplhqcdiyrstkagaklrkvl
ragssrpwqevlkdmvgldaldaqpllkyfqlvtqwlqeqnqqngevlgwpeyqwhpplp
dnypegidlvtdea