PDB entry 6eix
View 6eix on RCSB PDB site
Description: Crystal structure of the kinase domain of the Q207E mutant of ACVR1 (ALK2) in complex with a 2-aminopyridine inhibitor K02288
Class: signaling protein
Keywords: Kinase, ALK2, Receptor, BMP, Structural Genomics, Structural Genomics Consortium, SGC, SIGNALING PROTEIN
Deposited on
2017-09-19, released
2017-09-27
The last revision prior to the SCOPe 2.08 freeze date was dated
2018-02-28, with a file datestamp of
2018-02-23.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: N/A
AEROSPACI score: 0.25
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Activin receptor type-1
Species: Homo sapiens [TaxId:9606]
Gene: ACVR1, ACVRLK2
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d6eixa_ - Heterogens: A3F, EDO, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>6eixA (A:)
smttnvgdstladlldhsctsgsgsglpflvqrtvareitllecvgkgrygevwrgswqg
envavkifssrdekswfretelyntvmlrhenilgfiasdmtsrhsstqlwlithyhemg
slydylqlttldtvsclrivlsiasglahlhieifgtqgkpaiahrdlksknilvkkngq
cciadlglavmhsqstnqldvgnnprvgtkrymapevldetiqvdcfdsykrvdiwafgl
vlwevarrmvsngivedykppfydvvpndpsfedmrkvvcvdqqrpnipnrwfsdptlts
laklmkecwyqnpsarltalrikktltkidnsldklktdc
Sequence, based on observed residues (ATOM records): (download)
>6eixA (A:)
sgsglpflvqrtvareitllecvgkgrygevwrgswqgenvavkifssrdekswfretel
yntvmlrhenilgfiasdmtsrhsstqlwlithyhemgslydylqlttldtvsclrivls
iasglahlhieifgtqgkpaiahrdlksknilvkkngqcciadlglavmhsqstnqldvg
nnprvgtkrymapevldetiqvdcfdsykrvdiwafglvlwevarrmvsngivedykppf
ydvvpndpsfedmrkvvcvdqqrpnipnrwfsdptltslaklmkecwyqnpsarltalri
kktltkidnsld