PDB entry 6eix

View 6eix on RCSB PDB site
Description: Crystal structure of the kinase domain of the Q207E mutant of ACVR1 (ALK2) in complex with a 2-aminopyridine inhibitor K02288
Class: signaling protein
Keywords: Kinase, ALK2, Receptor, BMP, Structural Genomics, Structural Genomics Consortium, SGC, SIGNALING PROTEIN
Deposited on 2017-09-19, released 2017-09-27
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-02-28, with a file datestamp of 2018-02-23.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: N/A
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Activin receptor type-1
    Species: Homo sapiens [TaxId:9606]
    Gene: ACVR1, ACVRLK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q04771
      • engineered mutation (37)
    Domains in SCOPe 2.08: d6eixa_
  • Heterogens: A3F, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6eixA (A:)
smttnvgdstladlldhsctsgsgsglpflvqrtvareitllecvgkgrygevwrgswqg
envavkifssrdekswfretelyntvmlrhenilgfiasdmtsrhsstqlwlithyhemg
slydylqlttldtvsclrivlsiasglahlhieifgtqgkpaiahrdlksknilvkkngq
cciadlglavmhsqstnqldvgnnprvgtkrymapevldetiqvdcfdsykrvdiwafgl
vlwevarrmvsngivedykppfydvvpndpsfedmrkvvcvdqqrpnipnrwfsdptlts
laklmkecwyqnpsarltalrikktltkidnsldklktdc

    Sequence, based on observed residues (ATOM records): (download) 
    >6eixA (A:)
sgsglpflvqrtvareitllecvgkgrygevwrgswqgenvavkifssrdekswfretel
yntvmlrhenilgfiasdmtsrhsstqlwlithyhemgslydylqlttldtvsclrivls
iasglahlhieifgtqgkpaiahrdlksknilvkkngqcciadlglavmhsqstnqldvg
nnprvgtkrymapevldetiqvdcfdsykrvdiwafglvlwevarrmvsngivedykppf
ydvvpndpsfedmrkvvcvdqqrpnipnrwfsdptltslaklmkecwyqnpsarltalri
kktltkidnsld