PDB entry 6eiv

View 6eiv on RCSB PDB site
Description: DYRK1A in complex with JWD-065
Class: transferase
Keywords: Dual specificity tyrosine-phosphorylation-regulated kinase 1A, transferase
Deposited on 2017-09-19, released 2018-08-29
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-09-26, with a file datestamp of 2018-09-21.
Experiment type: XRAY
Resolution: 2.68 Å
R-factor: N/A
AEROSPACI score: 0.18 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: dual specificity tyrosine-phosphorylation-regulated kinase 1a
    Species: Homo sapiens [TaxId:9606]
    Gene: DYRK1A, DYRK, MNB, MNBH
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6eiva_
  • Chain 'B':
    Compound: dual specificity tyrosine-phosphorylation-regulated kinase 1a
    Species: Homo sapiens [TaxId:9606]
    Gene: DYRK1A, DYRK, MNB, MNBH
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: dual specificity tyrosine-phosphorylation-regulated kinase 1a
    Species: Homo sapiens [TaxId:9606]
    Gene: DYRK1A, DYRK, MNB, MNBH
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6eivc_
  • Chain 'D':
    Compound: dual specificity tyrosine-phosphorylation-regulated kinase 1a
    Species: Homo sapiens [TaxId:9606]
    Gene: DYRK1A, DYRK, MNB, MNBH
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6eivd_
  • Heterogens: B6Q, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6eivA (A:)
gasdsshkkerkvyndgydddnydyivkngekwmdryeidsligkgsfgqvvkaydrveq
ewvaikiiknkkaflnqaqievrllelmnkhdtemkyyivhlkrhfmfrnhlclvfemls
ynlydllrntnfrgvslnltrkfaqqmctallflatpelsiihcdlkpenillcnpkrsa
ikivdfgsscqlgqriyqyiqsrfyrspevllgmpydlaidmwslgcilvemhtgeplfs
ganevdqmnkivevlgippahildqapkarkffeklpdgtwnlkktkdgkreykppgtrk
lhnilgvetggpggrragesghtvadylkfkdlilrmldydpktriqpyyalqhsffkkt
adegtnts

    Sequence, based on observed residues (ATOM records): (download) 
    >6eivA (A:)
kvyndgydddnydyivkngekwmdryeidsligkgsfgqvvkaydrveqewvaikiiknk
kaflnqaqievrllelmnkhdtemkyyivhlkrhfmfrnhlclvfemlsynlydllrntn
frgvslnltrkfaqqmctallflatpelsiihcdlkpenillcnpkrsaikivdfgsscq
lgqriyqyiqsrfyrspevllgmpydlaidmwslgcilvemhtgeplfsganevdqmnki
vevlgippahildqapkarkffeklpdgtwnlkkteykppgtrklhnilgvetggpggrr
agesghtvadylkfkdlilrmldydpktriqpyyalqhsffk

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6eivC (C:)
gasdsshkkerkvyndgydddnydyivkngekwmdryeidsligkgsfgqvvkaydrveq
ewvaikiiknkkaflnqaqievrllelmnkhdtemkyyivhlkrhfmfrnhlclvfemls
ynlydllrntnfrgvslnltrkfaqqmctallflatpelsiihcdlkpenillcnpkrsa
ikivdfgsscqlgqriyqyiqsrfyrspevllgmpydlaidmwslgcilvemhtgeplfs
ganevdqmnkivevlgippahildqapkarkffeklpdgtwnlkktkdgkreykppgtrk
lhnilgvetggpggrragesghtvadylkfkdlilrmldydpktriqpyyalqhsffkkt
adegtnts

    Sequence, based on observed residues (ATOM records): (download) 
    >6eivC (C:)
vyndgydddnydyivkngekwmdryeidsligkgsfgqvvkaydrveqewvaikiiknkk
aflnqaqievrllelmnkhdtemkyyivhlkrhfmfrnhlclvfemlsynlydllrntnf
rgvslnltrkfaqqmctallflatpelsiihcdlkpenillcnpkrsaikivdfgsscql
gqriyqyiqsrfyrspevllgmpydlaidmwslgcilvemhtgeplfsganevdqmnkiv
evlgippahildqapkarkffwnlkkreykppgtrklhnilgvetggpggrragesghtv
adylkfkdlilrmldydpktriqpyyalqhsff

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6eivD (D:)
gasdsshkkerkvyndgydddnydyivkngekwmdryeidsligkgsfgqvvkaydrveq
ewvaikiiknkkaflnqaqievrllelmnkhdtemkyyivhlkrhfmfrnhlclvfemls
ynlydllrntnfrgvslnltrkfaqqmctallflatpelsiihcdlkpenillcnpkrsa
ikivdfgsscqlgqriyqyiqsrfyrspevllgmpydlaidmwslgcilvemhtgeplfs
ganevdqmnkivevlgippahildqapkarkffeklpdgtwnlkktkdgkreykppgtrk
lhnilgvetggpggrragesghtvadylkfkdlilrmldydpktriqpyyalqhsffkkt
adegtnts

    Sequence, based on observed residues (ATOM records): (download) 
    >6eivD (D:)
kvyndgydddnydyivkngekwmdryeidsligkgsfgqvvkaydrveqewvaikiiknk
kaflnqaqievrllelmnkhdtemkyyivhlkrhfmfrnhlclvfemlsynlydllrntn
frgvslnltrkfaqqmctallflatpelsiihcdlkpenillcnpkrsaikivdfgsscq
lgqriyqyiqsrfyrspevllgmpydlaidmwslgcilvemhtgeplfsganevdqmnki
vevlgippahildqapkarkffeklpdgtwnlkkykppgtrklhnilgvetggpggghtv
adylkfkdlilrmldydpktriqpyyalqhsff