PDB entry 6eg8

View 6eg8 on RCSB PDB site
Description: Structure of the GDP-bound Gs heterotrimer
Class: signaling protein
Keywords: G protein Heterotrimer GDP GPCR, SIGNALING PROTEIN
Deposited on 2018-08-19, released 2019-06-05
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-12-11, with a file datestamp of 2019-12-06.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: N/A
AEROSPACI score: 0.17 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
    Species: Homo sapiens [TaxId:9606]
    Gene: GNB1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6eg8a_
  • Chain 'B':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
    Species: Homo sapiens [TaxId:9606]
    Gene: GNB1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P62873 (6-344)
      • expression tag (4-5)
    Domains in SCOPe 2.08: d6eg8b1, d6eg8b2
  • Chain 'C':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
    Species: Homo sapiens [TaxId:9606]
    Gene: GNG2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6eg8c_
  • Chain 'D':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
    Species: Homo sapiens [TaxId:9606]
    Gene: GNB1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P62873 (6-344)
      • expression tag (4-5)
    Domains in SCOPe 2.08: d6eg8d1, d6eg8d2
  • Chain 'E':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
    Species: Homo sapiens [TaxId:9606]
    Gene: GNG2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6eg8e_
  • Chain 'F':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
    Species: Homo sapiens [TaxId:9606]
    Gene: GNB1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P62873 (6-344)
      • expression tag (5)
    Domains in SCOPe 2.08: d6eg8f1, d6eg8f2
  • Chain 'G':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
    Species: Homo sapiens [TaxId:9606]
    Gene: GNG2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6eg8g_
  • Chain 'H':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
    Species: Homo sapiens [TaxId:9606]
    Gene: GNG2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6eg8h_
  • Chain 'I':
    Compound: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
    Species: Homo sapiens [TaxId:9606]
    Gene: GNAS, GNAS1, GSP
    Database cross-references and differences (RAF-indexed):
  • Chain 'J':
    Compound: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
    Species: Homo sapiens [TaxId:9606]
    Gene: GNAS, GNAS1, GSP
    Database cross-references and differences (RAF-indexed):
  • Chain 'K':
    Compound: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
    Species: Homo sapiens [TaxId:9606]
    Gene: GNAS, GNAS1, GSP
    Database cross-references and differences (RAF-indexed):
  • Chain 'L':
    Compound: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
    Species: Homo sapiens [TaxId:9606]
    Gene: GNAS, GNAS1, GSP
    Database cross-references and differences (RAF-indexed):
  • Heterogens: GDP, MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6eg8A (A:)
gpgssgseldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrrtlrghl
akiyamhwgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgnyvacg
gldnicsiynlktregnvrvsrelaghtgylsccrflddnqivtssgdttcalwdietgq
qtttftghtgdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdinaicff
pngnafatgsddatcrlfdlradqelmtyshdniicgitsvsfsksgrlllagyddfncn
vwdalkadragvlaghdnrvsclgvtddgmavatgswdsflkiwn

    Sequence, based on observed residues (ATOM records): (download) 
    >6eg8A (A:)
seldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrrtlrghlakiyam
hwgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgnyvacggldnic
siynlktregnvrvsrelaghtgylsccrflddnqivtssgdttcalwdietgqqtttft
ghtgdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdinaicffpngnaf
atgsddatcrlfdlradqelmtyshdniicgitsvsfsksgrlllagyddfncnvwdalk
adragvlaghdnrvsclgvtddgmavatgswdsflkiwn

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6eg8B (B:)
gpgssgseldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrrtlrghl
akiyamhwgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgnyvacg
gldnicsiynlktregnvrvsrelaghtgylsccrflddnqivtssgdttcalwdietgq
qtttftghtgdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdinaicff
pngnafatgsddatcrlfdlradqelmtyshdniicgitsvsfsksgrlllagyddfncn
vwdalkadragvlaghdnrvsclgvtddgmavatgswdsflkiwn

    Sequence, based on observed residues (ATOM records): (download) 
    >6eg8B (B:)
sgseldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrrtlrghlakiy
amhwgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgnyvacggldn
icsiynlktregnvrvsrelaghtgylsccrflddnqivtssgdttcalwdietgqqttt
ftghtgdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdinaicffpngn
afatgsddatcrlfdlradqelmtyshdniicgitsvsfsksgrlllagyddfncnvwda
lkadragvlaghdnrvsclgvtddgmavatgswdsflkiwn

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6eg8C (C:)
masnntasiaqarklveqlkmeanidrikvskaaadlmayceahakedplltpvpasenp
frekkffsail

    Sequence, based on observed residues (ATOM records): (download) 
    >6eg8C (C:)
siaqarklveqlkmeanidrikvskaaadlmayceahakedplltpvpasenpfrek

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6eg8D (D:)
gpgssgseldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrrtlrghl
akiyamhwgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgnyvacg
gldnicsiynlktregnvrvsrelaghtgylsccrflddnqivtssgdttcalwdietgq
qtttftghtgdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdinaicff
pngnafatgsddatcrlfdlradqelmtyshdniicgitsvsfsksgrlllagyddfncn
vwdalkadragvlaghdnrvsclgvtddgmavatgswdsflkiwn

    Sequence, based on observed residues (ATOM records): (download) 
    >6eg8D (D:)
sgseldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrrtlrghlakiy
amhwgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgnyvacggldn
icsiynlktregnvrvsrelaghtgylsccrflddnqivtssgdttcalwdietgqqttt
ftghtgdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdinaicffpngn
afatgsddatcrlfdlradqelmtyshdniicgitsvsfsksgrlllagyddfncnvwda
lkadragvlaghdnrvsclgvtddgmavatgswdsflkiwn

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >6eg8E (E:)
masnntasiaqarklveqlkmeanidrikvskaaadlmayceahakedplltpvpasenp
frekkffsail

    Sequence, based on observed residues (ATOM records): (download) 
    >6eg8E (E:)
ntasiaqarklveqlkmeanidrikvskaaadlmayceahakedplltpvpasenpfrek

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >6eg8F (F:)
gpgssgseldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrrtlrghl
akiyamhwgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgnyvacg
gldnicsiynlktregnvrvsrelaghtgylsccrflddnqivtssgdttcalwdietgq
qtttftghtgdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdinaicff
pngnafatgsddatcrlfdlradqelmtyshdniicgitsvsfsksgrlllagyddfncn
vwdalkadragvlaghdnrvsclgvtddgmavatgswdsflkiwn

    Sequence, based on observed residues (ATOM records): (download) 
    >6eg8F (F:)
gseldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrrtlrghlakiya
mhwgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgnyvacggldni
csiynlktregnvrvsrelaghtgylsccrflddnqivtssgdttcalwdietgqqtttf
tghtgdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdinaicffpngna
fatgsddatcrlfdlradqelmtyshdniicgitsvsfsksgrlllagyddfncnvwdal
kadragvlaghdnrvsclgvtddgmavatgswdsflkiwn

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >6eg8G (G:)
masnntasiaqarklveqlkmeanidrikvskaaadlmayceahakedplltpvpasenp
frekkffsail

    Sequence, based on observed residues (ATOM records): (download) 
    >6eg8G (G:)
siaqarklveqlkmeanidrikvskaaadlmayceahakedplltpvpasenpfrek

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >6eg8H (H:)
masnntasiaqarklveqlkmeanidrikvskaaadlmayceahakedplltpvpasenp
frekkffsail

    Sequence, based on observed residues (ATOM records): (download) 
    >6eg8H (H:)
asiaqarklveqlkmeanidrikvskaaadlmayceahakedplltpvpasenpfre

  • Chain 'I':
    No sequence available.

  • Chain 'J':
    No sequence available.

  • Chain 'K':
    No sequence available.

  • Chain 'L':
    No sequence available.