PDB entry 6eeh
View 6eeh on RCSB PDB site
Description: Bioreductive 4-hydroxy-3-nitro-5-ureido-benzenesulfonamides selectively target the tumor-associated carbonic anhydrase isoforms IX and XII and show hypoxia-enhanced cytotoxicity against human cancer cell lines.
Class: LYASE/LYASE inhibitor
Keywords: Hypoxia, carbonic anhydrase IX, carbonic anhydrase XII, inhibition, anti-proliferative., LYASE, LYASE-LYASE inhibitor complex
Deposited on
2018-08-14, released
2018-11-28
The last revision prior to the SCOPe 2.08 freeze date was dated
2019-05-01, with a file datestamp of
2019-04-26.
Experiment type: XRAY
Resolution: 1.63 Å
R-factor: N/A
AEROSPACI score: 0.44
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Carbonic anhydrase 2
Species: Homo sapiens [TaxId:9606]
Gene: CA2
Database cross-references and differences (RAF-indexed):
- Uniprot P00918 (0-256)
- engineered mutation (61)
- engineered mutation (63)
- engineered mutation (65)
- engineered mutation (87)
- engineered mutation (126)
- engineered mutation (165)
- engineered mutation (199)
Domains in SCOPe 2.08: d6eeha_ - Heterogens: J4D, ZN, HOH