PDB entry 6ee1

View 6ee1 on RCSB PDB site
Description: crystal structure of mycobacterium tuberculosis icl2 in complex with acetyl-coa
Deposited on 2018-08-12, released 2019-08-14
The last revision was dated 2019-10-23, with a file datestamp of 2019-10-18.
Experiment type: XRAY
Resolution: 2.36 Å
R-factor: N/A
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Isocitrate lyase 2
    Species: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) [TaxId:83331]
    Gene: icl2, aceA-2, MT1966
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Isocitrate lyase 2
    Species: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) [TaxId:83331]
    Gene: icl2, aceA-2, MT1966
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Isocitrate lyase 2
    Species: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) [TaxId:83331]
    Gene: icl2, aceA-2, MT1966
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: Isocitrate lyase 2
    Species: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) [TaxId:83331]
    Gene: icl2, aceA-2, MT1966
    Database cross-references and differences (RAF-indexed):
  • Heterogens: ACO, MG, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6ee1A (A:)
mgsshhhhhhssglvprgshmaiaetdtevhtpfeqdfekdvaatqryfdssrfagiirl
ytarqvveqrgtipvdhivareaagafyerlrelfaarksittfgpyspgqavsmkrmgi
eaiylggwatsakgsstedpgpdlasyplsqvpddaavlvralltadrnqhylrlqmser
qraatpaydfrpfiiadadtghggdphvrnlirrfvevgvpgyhiedqrpgtkkcghqgg
kvlvpsdeqikrlnaarfqldimrvpgiivartdaeaanlidsraderdqpfllgatkld
vpsykscflamvrrfyelgvkelnghllyalgdseyaaaggwlerqgifglvsdavnawr
edgqqsidgifdqvesrfvaaweddaglmtygeavadvlefgqsegepigmapeewrafa
araslhaarakakelgadppwdcelaktpegyyqirggipyaiakslaaapfadilwmet
ktadladarqfaeaihaefpdqmlaynlspsfnwdttgmtdeemrrfpeelgkmgfvfnf
itygghqidgvaaeefatalrqdgmlalarlqrkmrlvespyrtpqtlvggprsdaalaa
ssgrtattkamgkgstqhqhlvqtevprklleewlamwsghyqlkdklrvqlrpqragse
vlelgihgesddklanvifqpiqdrrgrtillvrdqntfgaelrqkrlmtlihlwlvhrf
kaqavhyvtptddnlyqtskmkshgiftevnqevgeiivaevnhpriaelltpdrvalrk
litkea

    Sequence, based on observed residues (ATOM records):
    >6ee1A (A:)
tpfeqdfekdvaatqryfdssrfagiirlytarqvveqrgtipvdhivareaagafyerl
relfaarksittfgpyspgqavsmkrmgieaiylggwatsakgsstedpgpdlasyplsq
vpddaavlvralltadrnqhylrlqmserqraatpaydfrpfiiadadtghggdphvrnl
irrfvevgvpgyhiedqrpgtkkcggkvlvpsdeqikrlnaarfqldimrvpgiivartd
aeaanlidsraderdqpfllgatkldvpsykscflamvrrfyelgvkelnghllyalgds
eyaaaggwlerqgifglvsdavnawredgsidgifdqvesrfvaaweddaglmtygeava
dvleapeewrafaaraslhaarakakelgdppwdcelaktpegyyqirggipyaiaksla
aapfadilwmetktadladarqfaeaihaefpdqmlaynlspsfnwdttgmtdeemrrfp
eelgkmgfvfnfitygghqidgvaaeefatalrqdgmlalarlqrkmrlvespyrtpqtl
vggprsdaalaassgrtatvqtevprklleewlamwsghyqlklrvqlrpqragsevlel
gihgesdklanvifqpiqdrrgrtillvrdqntfgaelrqkrlmtlihlwlvhrfkaqav
hyvtptddnlyqtskmkshgiftevnqevgeiivaevnhpriaelltpdrvalrklitk

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6ee1B (B:)
mgsshhhhhhssglvprgshmaiaetdtevhtpfeqdfekdvaatqryfdssrfagiirl
ytarqvveqrgtipvdhivareaagafyerlrelfaarksittfgpyspgqavsmkrmgi
eaiylggwatsakgsstedpgpdlasyplsqvpddaavlvralltadrnqhylrlqmser
qraatpaydfrpfiiadadtghggdphvrnlirrfvevgvpgyhiedqrpgtkkcghqgg
kvlvpsdeqikrlnaarfqldimrvpgiivartdaeaanlidsraderdqpfllgatkld
vpsykscflamvrrfyelgvkelnghllyalgdseyaaaggwlerqgifglvsdavnawr
edgqqsidgifdqvesrfvaaweddaglmtygeavadvlefgqsegepigmapeewrafa
araslhaarakakelgadppwdcelaktpegyyqirggipyaiakslaaapfadilwmet
ktadladarqfaeaihaefpdqmlaynlspsfnwdttgmtdeemrrfpeelgkmgfvfnf
itygghqidgvaaeefatalrqdgmlalarlqrkmrlvespyrtpqtlvggprsdaalaa
ssgrtattkamgkgstqhqhlvqtevprklleewlamwsghyqlkdklrvqlrpqragse
vlelgihgesddklanvifqpiqdrrgrtillvrdqntfgaelrqkrlmtlihlwlvhrf
kaqavhyvtptddnlyqtskmkshgiftevnqevgeiivaevnhpriaelltpdrvalrk
litkea

    Sequence, based on observed residues (ATOM records):
    >6ee1B (B:)
htpfeqdfekdvaatqryfdssrfagiirlytarqvveqrgtipvdhivareaagafyer
lrelfaarksittfgpyspgqavsmkrmgieaiylggwatsakgsstedpgpdlasypls
qvpddaavlvralltadrnqhylrlqmserqraatpaydfrpfiiadadtghggdphvrn
lirrfvevgvpgyhiedqrpgtkkcgggkvlvpsdeqikrlnaarfqldimrvpgiivar
tdaeaanlidsraderdqpfllgatkldvpsykscflamvrrfyelgvkelnghllyalg
dseyaaaggwlerqgifglvsdavnawredqqsidgifdqvesrfvaaweddaglmtyge
avadvlefgapeewrafaaraslhaarakakeladppwdcelaktpegyyqirggipyai
akslaaapfadilwmetktadladarqfaeaihaefpdqmlaynlspsfnwdttgmtdee
mrrfpeelgkmgfvfnfitygghqidgvaaeefatalrqdgmlalarlqrkmrlvespyr
tpqtlvggprsdaalaassgrtattlvqtevprklleewlamwsghyqlkdklrvqlrpq
ragsevlelgihgesddklanvifqpiqdrrgrtillvrdqntfgaelrqkrlmtlihlw
lvhrfkaqavhyvtptddnlyqtskmkshgiftevnqevgeiivaevnhpriaelltpdr
valrklitk

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6ee1C (C:)
mgsshhhhhhssglvprgshmaiaetdtevhtpfeqdfekdvaatqryfdssrfagiirl
ytarqvveqrgtipvdhivareaagafyerlrelfaarksittfgpyspgqavsmkrmgi
eaiylggwatsakgsstedpgpdlasyplsqvpddaavlvralltadrnqhylrlqmser
qraatpaydfrpfiiadadtghggdphvrnlirrfvevgvpgyhiedqrpgtkkcghqgg
kvlvpsdeqikrlnaarfqldimrvpgiivartdaeaanlidsraderdqpfllgatkld
vpsykscflamvrrfyelgvkelnghllyalgdseyaaaggwlerqgifglvsdavnawr
edgqqsidgifdqvesrfvaaweddaglmtygeavadvlefgqsegepigmapeewrafa
araslhaarakakelgadppwdcelaktpegyyqirggipyaiakslaaapfadilwmet
ktadladarqfaeaihaefpdqmlaynlspsfnwdttgmtdeemrrfpeelgkmgfvfnf
itygghqidgvaaeefatalrqdgmlalarlqrkmrlvespyrtpqtlvggprsdaalaa
ssgrtattkamgkgstqhqhlvqtevprklleewlamwsghyqlkdklrvqlrpqragse
vlelgihgesddklanvifqpiqdrrgrtillvrdqntfgaelrqkrlmtlihlwlvhrf
kaqavhyvtptddnlyqtskmkshgiftevnqevgeiivaevnhpriaelltpdrvalrk
litkea

    Sequence, based on observed residues (ATOM records):
    >6ee1C (C:)
tpfeqdfekdvaatqryfdssrfagiirlytarqvveqrgtipvdhivareaagafyerl
relfaarksittfgpyspgqavsmkrmgieaiylggwatsakgsstedpgpdlasyplsq
vpddaavlvralltadrnqhylrlqmserqraatpaydfrpfiiadadtghggdphvrnl
irrfvevgvpgyhiedqrpgtkkcgggkvlvpsdeqikrlnaarfqldimrvpgiivart
daeaanlidsraderdqpfllgaldvpsykscflamvrrfyelgvkelnghllyalgdse
yaaaggwlerqgifglvsdavnawredqsidgifdqvesrfvaaweddaglmtygeavad
vlemapeewrafaaraslhaarakakeladppwdcelaktpegyyqirggipyaiaksla
aapfadilwmetktadladarqfaeaihaefpdqmlaynlspsfnwdttgmtdeemrrfp
eelgkmgfvfnfitygghqidgvaaeefatalrqdgmlalarlqrkmrlvespyrtpqtl
vggprsdaalaassgrtatvqtevprklleewlamwsghyqlkdklrvqlrpqragsevl
elgihgesddklanvifqpiqdrrgrtillvrdqntfgaelrqkrlmtlihlwlvhrfka
qavhyvtptddnlyqtskmkshgiftevnqevgeiivaevnhpriaelltpdrvalrkli
tk

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6ee1D (D:)
mgsshhhhhhssglvprgshmaiaetdtevhtpfeqdfekdvaatqryfdssrfagiirl
ytarqvveqrgtipvdhivareaagafyerlrelfaarksittfgpyspgqavsmkrmgi
eaiylggwatsakgsstedpgpdlasyplsqvpddaavlvralltadrnqhylrlqmser
qraatpaydfrpfiiadadtghggdphvrnlirrfvevgvpgyhiedqrpgtkkcghqgg
kvlvpsdeqikrlnaarfqldimrvpgiivartdaeaanlidsraderdqpfllgatkld
vpsykscflamvrrfyelgvkelnghllyalgdseyaaaggwlerqgifglvsdavnawr
edgqqsidgifdqvesrfvaaweddaglmtygeavadvlefgqsegepigmapeewrafa
araslhaarakakelgadppwdcelaktpegyyqirggipyaiakslaaapfadilwmet
ktadladarqfaeaihaefpdqmlaynlspsfnwdttgmtdeemrrfpeelgkmgfvfnf
itygghqidgvaaeefatalrqdgmlalarlqrkmrlvespyrtpqtlvggprsdaalaa
ssgrtattkamgkgstqhqhlvqtevprklleewlamwsghyqlkdklrvqlrpqragse
vlelgihgesddklanvifqpiqdrrgrtillvrdqntfgaelrqkrlmtlihlwlvhrf
kaqavhyvtptddnlyqtskmkshgiftevnqevgeiivaevnhpriaelltpdrvalrk
litkea

    Sequence, based on observed residues (ATOM records):
    >6ee1D (D:)
htpfeqdfekdvaatqryfdssrfagiirlytarqvveqrgtipvdhivareaagafyer
lrelfaarksittfgpyspgqavsmkrmgieaiylggwatsakgsstedpgpdlasypls
qvpddaavlvralltadrnqhylrlqmserqraatpaydfrpfiiadadtghggdphvrn
lirrfvevgvpgyhiedqrpgtkkcgggkvlvpsdeqikrlnaarfqldimrvpgiivar
tdaeaanlidsraderdqpfllgatkldvpsykscflamvrrfyelgvkelnghllyalg
dseyaaaggwlerqgifglvsdavnawredqqsidgifdqvesrfvaaweddaglmtyge
avadvlefapeewrafaaraslhaarakakelgadppwdcelaktpegyyqirggipyai
akslaaapfadilwmetktadladarqfaeaihaefpdqmlaynlspsfnwdttgmtdee
mrrfpeelgkmgfvfnfitygghqidgvaaeefatalrqdgmlalarlqrkmrlvespyr
tpqtlvggprsdaalaassgrtattvqtevprklleewlamwsghyqlkdklrvqlrpqr
agsevlelgihgesddklanvifqpiqdrrgrtillvrdqntfgaelrqkrlmtlihlwl
vhrfkaqavhyvtptddnlyqtskmkshgiftevnqevgeiivaevnhpriaelltpdrv
alrklitkea