PDB entry 6edu

View 6edu on RCSB PDB site
Description: b41 sosip.664 in complex with soluble cd4 (d1-d2), the co-receptor mimicking antibody 21c and the broadly neutralizing antibody 8anc195
Deposited on 2018-08-11, released 2018-10-17
The last revision was dated 2020-07-29, with a file datestamp of 2020-07-09.
Experiment type: EM
Resolution: 4.06 Å
R-factor: N/A
AEROSPACI score: 0.11 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: envelope glycoprotein gp160
    Species: Human immunodeficiency virus 1 [TaxId:11676]
    Gene: ENV
    Database cross-references and differences (RAF-indexed):
    • Uniprot B3UEZ6
      • conflict (93)
  • Chain 'B':
    Compound: envelope glycoprotein gp160
    Species: Human immunodeficiency virus 1 [TaxId:11676]
    Gene: ENV
    Database cross-references and differences (RAF-indexed):
    • Uniprot B3UEZ6
      • conflict (93)
  • Chain 'C':
    Compound: envelope glycoprotein gp160
    Species: Human immunodeficiency virus 1 [TaxId:11676]
    Gene: ENV
    Database cross-references and differences (RAF-indexed):
    • Uniprot B3UEZ6
      • conflict (93)
  • Chain 'D':
    Compound: envelope glycoprotein gp160
    Species: Human immunodeficiency virus 1 [TaxId:11676]
    Gene: ENV
    Database cross-references and differences (RAF-indexed):
    • Uniprot B3UES2
      • conflict (511)
  • Chain 'E':
    Compound: envelope glycoprotein gp160
    Species: Human immunodeficiency virus 1 [TaxId:11676]
    Gene: ENV
    Database cross-references and differences (RAF-indexed):
    • Uniprot B3UES2
      • conflict (511)
  • Chain 'F':
    Compound: envelope glycoprotein gp160
    Species: Human immunodeficiency virus 1 [TaxId:11676]
    Gene: ENV
    Database cross-references and differences (RAF-indexed):
    • Uniprot B3UES2
      • conflict (511)
  • Chain 'G':
    Compound: T-cell surface glycoprotein cd4
    Species: Homo sapiens [TaxId:9606]
    Gene: CD4
    Database cross-references and differences (RAF-indexed):
  • Chain 'H':
    Compound: T-cell surface glycoprotein cd4
    Species: Homo sapiens [TaxId:9606]
    Gene: CD4
    Database cross-references and differences (RAF-indexed):
  • Chain 'I':
    Compound: T-cell surface glycoprotein cd4
    Species: Homo sapiens [TaxId:9606]
    Gene: CD4
    Database cross-references and differences (RAF-indexed):
  • Chain 'J':
    Compound: 21c Fab VH domain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6EDU (0-End)
  • Chain 'K':
    Compound: 21c Fab VL domain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6EDU
  • Chain 'L':
    Compound: 21c Fab VH domain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6EDU (0-End)
  • Chain 'M':
    Compound: 21c Fab VL domain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6EDU
  • Chain 'N':
    Compound: 21c Fab VH domain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6EDU (0-End)
  • Chain 'O':
    Compound: 21c Fab VL domain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6EDU
  • Chain 'P':
    Compound: 8ANC195 G52K5 Fab VH domain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6EDU (0-End)
  • Chain 'Q':
    Compound: 8ANC195 G52K5 Fab VL domain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6EDU (0-End)
  • Chain 'R':
    Compound: 8ANC195 G52K5 Fab VH domain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6EDU (0-End)
  • Chain 'S':
    Compound: 8ANC195 G52K5 Fab VL domain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6EDU (0-End)
  • Chain 'T':
    Compound: 8ANC195 G52K5 Fab VH domain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6EDU (0-End)
  • Chain 'U':
    Compound: 8ANC195 G52K5 Fab VL domain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6EDU (0-End)
  • Heterogens: NAG

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6eduA (A:)
avglgafilgflgaagstmgaasmaltvqarlllsgivqqqnnllrapeaqqhmlqltvw
gikqlqarvlaverylrdqqllgiwgcsgkiicctnvpwndswsnktineiwdnmtwmqw
ekeidnytqhiytllevsqiqqekneqelleld

    Sequence, based on observed residues (ATOM records):
    >6eduA (A:)
filgflgaagstmgaasmaltvqarllhmlqltvwgikqlqarvlaverylrdqqllgiw
gcsgkiicctnvpwndswsnktineiwdnmtwmqwekeidnytqhiytllevsqiq

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6eduB (B:)
avglgafilgflgaagstmgaasmaltvqarlllsgivqqqnnllrapeaqqhmlqltvw
gikqlqarvlaverylrdqqllgiwgcsgkiicctnvpwndswsnktineiwdnmtwmqw
ekeidnytqhiytllevsqiqqekneqelleld

    Sequence, based on observed residues (ATOM records):
    >6eduB (B:)
filgflgaagstmgaasmaltvqarllhmlqltvwgikqlqarvlaverylrdqqllgiw
gcsgkiicctnvpwndswsnktineiwdnmtwmqwekeidnytqhiytllevsqiq

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6eduC (C:)
avglgafilgflgaagstmgaasmaltvqarlllsgivqqqnnllrapeaqqhmlqltvw
gikqlqarvlaverylrdqqllgiwgcsgkiicctnvpwndswsnktineiwdnmtwmqw
ekeidnytqhiytllevsqiqqekneqelleld

    Sequence, based on observed residues (ATOM records):
    >6eduC (C:)
filgflgaagstmgaasmaltvqarllhmlqltvwgikqlqarvlaverylrdqqllgiw
gcsgkiicctnvpwndswsnktineiwdnmtwmqwekeidnytqhiytllevsqiq

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6eduD (D:)
mdamkrglccvlllcgavfvspsqeiharfrrgaraakkwvtvyygvpvwkeatttlfca
sdakaydtevhnvwathacvptdpnpqeivlgnvtenfnmwknnmveqmhediislwdqs
lkpcvkltplcvtlncnnvntnntnnstnatisdwekmetgemkncsfnvttsirdkikk
eyalfykldvvplenknninntnitnyrlincntsvitqacpkvsfepipihycapagfa
ilkcnsktfngsgpctnvstvqcthgirpvvstqlllngslaeeeivirsenitdnakti
ivqlneaveinctrpnnntrksihigpgrafyatgdiignirqahcniskarwnetlgqi
vakleeqfpnktiifnhssggdpeivthsfncggeffycnttplfnstwnntrtddyptg
geqnitlqcrikqiinmwqgvgkamyappirgqircssnitgllltrdggrdqngtetfr
pgggnmrdnwrselykykvvkieplgiaptackrrv

    Sequence, based on observed residues (ATOM records):
    >6eduD (D:)
kkwvtvyygvpvwkeatttlfcasdnvwathacvptdpnpqeivlgnvtenfnmwknnmv
eqmhediislwdqslkpcvkltplcvtekmetgemkncsfnvttsirdkikkeyalfykl
dvyrlincntsvitqacpkvsfepipihycapagfailkcnsktfngsgpctnvstvqct
hgirpvvstqlllngslaeeeivirsenitdnaktiivqlneaveinctrpngnirqahc
niskarwnetlgqivakleeqfpnktiifnhssggdpeivthsfncggeffycnttplfn
stwnnttggeqnitlqcrikqiinmwqgvgkamyappirgqircssnitgllltrdggrd
qngtetfrpgggnmrdnwrselykykvvkieplgiaptack

  • Chain 'E':
    Sequence, based on SEQRES records:
    >6eduE (E:)
mdamkrglccvlllcgavfvspsqeiharfrrgaraakkwvtvyygvpvwkeatttlfca
sdakaydtevhnvwathacvptdpnpqeivlgnvtenfnmwknnmveqmhediislwdqs
lkpcvkltplcvtlncnnvntnntnnstnatisdwekmetgemkncsfnvttsirdkikk
eyalfykldvvplenknninntnitnyrlincntsvitqacpkvsfepipihycapagfa
ilkcnsktfngsgpctnvstvqcthgirpvvstqlllngslaeeeivirsenitdnakti
ivqlneaveinctrpnnntrksihigpgrafyatgdiignirqahcniskarwnetlgqi
vakleeqfpnktiifnhssggdpeivthsfncggeffycnttplfnstwnntrtddyptg
geqnitlqcrikqiinmwqgvgkamyappirgqircssnitgllltrdggrdqngtetfr
pgggnmrdnwrselykykvvkieplgiaptackrrv

    Sequence, based on observed residues (ATOM records):
    >6eduE (E:)
kkwvtvyygvpvwkeatttlfcasdnvwathacvptdpnpqeivlgnvtenfnmwknnmv
eqmhediislwdqslkpcvkltplcvtekmetgemkncsfnvttsirdkikkeyalfykl
dvyrlincntsvitqacpkvsfepipihycapagfailkcnsktfngsgpctnvstvqct
hgirpvvstqlllngslaeeeivirsenitdnaktiivqlneaveinctrpngnirqahc
niskarwnetlgqivakleeqfpnktiifnhssggdpeivthsfncggeffycnttplfn
stwnnttggeqnitlqcrikqiinmwqgvgkamyappirgqircssnitgllltrdggrd
qngtetfrpgggnmrdnwrselykykvvkieplgiaptack

  • Chain 'F':
    Sequence, based on SEQRES records:
    >6eduF (F:)
mdamkrglccvlllcgavfvspsqeiharfrrgaraakkwvtvyygvpvwkeatttlfca
sdakaydtevhnvwathacvptdpnpqeivlgnvtenfnmwknnmveqmhediislwdqs
lkpcvkltplcvtlncnnvntnntnnstnatisdwekmetgemkncsfnvttsirdkikk
eyalfykldvvplenknninntnitnyrlincntsvitqacpkvsfepipihycapagfa
ilkcnsktfngsgpctnvstvqcthgirpvvstqlllngslaeeeivirsenitdnakti
ivqlneaveinctrpnnntrksihigpgrafyatgdiignirqahcniskarwnetlgqi
vakleeqfpnktiifnhssggdpeivthsfncggeffycnttplfnstwnntrtddyptg
geqnitlqcrikqiinmwqgvgkamyappirgqircssnitgllltrdggrdqngtetfr
pgggnmrdnwrselykykvvkieplgiaptackrrv

    Sequence, based on observed residues (ATOM records):
    >6eduF (F:)
kkwvtvyygvpvwkeatttlfcasdnvwathacvptdpnpqeivlgnvtenfnmwknnmv
eqmhediislwdqslkpcvkltplcvtekmetgemkncsfnvttsirdkikkeyalfykl
dvyrlincntsvitqacpkvsfepipihycapagfailkcnsktfngsgpctnvstvqct
hgirpvvstqlllngslaeeeivirsenitdnaktiivqlneaveinctrpngnirqahc
niskarwnetlgqivakleeqfpnktiifnhssggdpeivthsfncggeffycnttplfn
stwnnttggeqnitlqcrikqiinmwqgvgkamyappirgqircssnitgllltrdggrd
qngtetfrpgggnmrdnwrselykykvvkieplgiaptack

  • Chain 'G':
    Sequence, based on SEQRES records:
    >6eduG (G:)
kkvvlgkkgdtveltctasqkksiqfhwknsnqikilgnqgsfltkgpsklndradsrrs
lwdqgnfpliiknlkiedsdtyicevedqkeevqllvfgltansdthllqgqsltltles
ppgsspsvqcrsprgkniqggktlsvsqlelqdsgtwtctvlqnqkkvefkidivvlafq
kasnt

    Sequence, based on observed residues (ATOM records):
    >6eduG (G:)
kkvvlgkkgdtveltctasqkksiqfhwknsnqikilgnqgsfltkgpsklndradsrrs
lwdqgnfpliiknlkiedsdtyicevedqkeevqllv

  • Chain 'H':
    Sequence, based on SEQRES records:
    >6eduH (H:)
kkvvlgkkgdtveltctasqkksiqfhwknsnqikilgnqgsfltkgpsklndradsrrs
lwdqgnfpliiknlkiedsdtyicevedqkeevqllvfgltansdthllqgqsltltles
ppgsspsvqcrsprgkniqggktlsvsqlelqdsgtwtctvlqnqkkvefkidivvlafq
kasnt

    Sequence, based on observed residues (ATOM records):
    >6eduH (H:)
kkvvlgkkgdtveltctasqkksiqfhwknsnqikilgnqgsfltkgpsklndradsrrs
lwdqgnfpliiknlkiedsdtyicevedqkeevqllv

  • Chain 'I':
    Sequence, based on SEQRES records:
    >6eduI (I:)
kkvvlgkkgdtveltctasqkksiqfhwknsnqikilgnqgsfltkgpsklndradsrrs
lwdqgnfpliiknlkiedsdtyicevedqkeevqllvfgltansdthllqgqsltltles
ppgsspsvqcrsprgkniqggktlsvsqlelqdsgtwtctvlqnqkkvefkidivvlafq
kasnt

    Sequence, based on observed residues (ATOM records):
    >6eduI (I:)
kkvvlgkkgdtveltctasqkksiqfhwknsnqikilgnqgsfltkgpsklndradsrrs
lwdqgnfpliiknlkiedsdtyicevedqkeevqllv

  • Chain 'J':
    Sequence, based on SEQRES records:
    >6eduJ (J:)
qvqvvqsgaevrkpgasvkvsckvsgftltglsihwvrqapgkglewmggfgpeeneiiy
aqkfqgrvsmtedtstntaymelsslrsedtavyycatggnyynlwtgyyplaywgqgtl
vtvssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpa
vlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepkscdkt

    Sequence, based on observed residues (ATOM records):
    >6eduJ (J:)
qvqvvqsgaevrkpgasvkvsckvsgftltglsihwvrqapgkglewmggfgpeeneiiy
aqkfqgrvsmtedtstntaymelsslrsedtavyycatggnyynlwtgyyplaywgqgtl
vtvs

  • Chain 'K':
    Sequence, based on SEQRES records:
    >6eduK (K:)
qsvltqppsvsaapgqkvtiscsgsssnigknyvswyqqlpgaapkllifddtqrpsgip
drfsgsksgtsatlaitglqtgdeadyycgtwdsslstgqlfgggtkltvlgqpkaapsv
tlfppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaas
sylsltpeqwkshrsyscqvthegstvektmahaecs

    Sequence, based on observed residues (ATOM records):
    >6eduK (K:)
svltqppsvsaapgqkvtiscsgsssnigknyvswyqqlpgaapkllifddtqrpsgipd
rfsgsksgtsatlaitglqtgdeadyycgtwdsslstgqlfgggtkltvlg

  • Chain 'L':
    Sequence, based on SEQRES records:
    >6eduL (L:)
qvqvvqsgaevrkpgasvkvsckvsgftltglsihwvrqapgkglewmggfgpeeneiiy
aqkfqgrvsmtedtstntaymelsslrsedtavyycatggnyynlwtgyyplaywgqgtl
vtvssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpa
vlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepkscdkt

    Sequence, based on observed residues (ATOM records):
    >6eduL (L:)
qvqvvqsgaevrkpgasvkvsckvsgftltglsihwvrqapgkglewmggfgpeeneiiy
aqkfqgrvsmtedtstntaymelsslrsedtavyycatggnyynlwtgyyplaywgqgtl
vtvs

  • Chain 'M':
    Sequence, based on SEQRES records:
    >6eduM (M:)
qsvltqppsvsaapgqkvtiscsgsssnigknyvswyqqlpgaapkllifddtqrpsgip
drfsgsksgtsatlaitglqtgdeadyycgtwdsslstgqlfgggtkltvlgqpkaapsv
tlfppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaas
sylsltpeqwkshrsyscqvthegstvektmahaecs

    Sequence, based on observed residues (ATOM records):
    >6eduM (M:)
svltqppsvsaapgqkvtiscsgsssnigknyvswyqqlpgaapkllifddtqrpsgipd
rfsgsksgtsatlaitglqtgdeadyycgtwdsslstgqlfgggtkltvlg

  • Chain 'N':
    Sequence, based on SEQRES records:
    >6eduN (N:)
qvqvvqsgaevrkpgasvkvsckvsgftltglsihwvrqapgkglewmggfgpeeneiiy
aqkfqgrvsmtedtstntaymelsslrsedtavyycatggnyynlwtgyyplaywgqgtl
vtvssastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpa
vlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepkscdkt

    Sequence, based on observed residues (ATOM records):
    >6eduN (N:)
qvqvvqsgaevrkpgasvkvsckvsgftltglsihwvrqapgkglewmggfgpeeneiiy
aqkfqgrvsmtedtstntaymelsslrsedtavyycatggnyynlwtgyyplaywgqgtl
vtvs

  • Chain 'O':
    Sequence, based on SEQRES records:
    >6eduO (O:)
qsvltqppsvsaapgqkvtiscsgsssnigknyvswyqqlpgaapkllifddtqrpsgip
drfsgsksgtsatlaitglqtgdeadyycgtwdsslstgqlfgggtkltvlgqpkaapsv
tlfppsseelqankatlvclisdfypgavtvawkadsspvkagvetttpskqsnnkyaas
sylsltpeqwkshrsyscqvthegstvektmahaecs

    Sequence, based on observed residues (ATOM records):
    >6eduO (O:)
svltqppsvsaapgqkvtiscsgsssnigknyvswyqqlpgaapkllifddtqrpsgipd
rfsgsksgtsatlaitglqtgdeadyycgtwdsslstgqlfgggtkltvlg

  • Chain 'P':
    Sequence, based on SEQRES records:
    >6eduP (P:)
qihlvqsgtevkkpgssvtvsckaygvntfglyavnwvrqapgqsleyigqiwrwkssas
hhfrgrvlisavdltgssppissleiknltsddtavyfctttstydkwsglhhdgvmafs
swgqgtlisvsaastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgalts
gvhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkrvepkscdkthh
hhhh

    Sequence, based on observed residues (ATOM records):
    >6eduP (P:)
qihlvqsgtevkkpgssvtvsckaygvntfglyavnwvrqapgqsleyigqiwrwkssas
hhfrgrvlisavdltgssppissleiknltsddtavyfctttstydkwsglhhdgvmafs
swgqgtlisvs

  • Chain 'Q':
    Sequence, based on SEQRES records:
    >6eduQ (Q:)
diqmtqspstlsasigdtvriscrasqsitgnwvawyqqrpgkaprlliyrgaallggvp
srfsgsaagtdftltignlqaedfgtfycqqydtypgtfgqgtkvevkrtvaapsvfifp
psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstl
tlskadyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records):
    >6eduQ (Q:)
diqmtqspstlsasigdtvriscrasqsitgnwvawyqqrpgkaprlliyrgaallggvp
srfsgsaagtdftltignlqaedfgtfycqqydtypgtfgqgtkvev

  • Chain 'R':
    Sequence, based on SEQRES records:
    >6eduR (R:)
qihlvqsgtevkkpgssvtvsckaygvntfglyavnwvrqapgqsleyigqiwrwkssas
hhfrgrvlisavdltgssppissleiknltsddtavyfctttstydkwsglhhdgvmafs
swgqgtlisvsaastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgalts
gvhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkrvepkscdkthh
hhhh

    Sequence, based on observed residues (ATOM records):
    >6eduR (R:)
qihlvqsgtevkkpgssvtvsckaygvntfglyavnwvrqapgqsleyigqiwrwkssas
hhfrgrvlisavdltgssppissleiknltsddtavyfctttstydkwsglhhdgvmafs
swgqgtlisvs

  • Chain 'S':
    Sequence, based on SEQRES records:
    >6eduS (S:)
diqmtqspstlsasigdtvriscrasqsitgnwvawyqqrpgkaprlliyrgaallggvp
srfsgsaagtdftltignlqaedfgtfycqqydtypgtfgqgtkvevkrtvaapsvfifp
psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstl
tlskadyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records):
    >6eduS (S:)
diqmtqspstlsasigdtvriscrasqsitgnwvawyqqrpgkaprlliyrgaallggvp
srfsgsaagtdftltignlqaedfgtfycqqydtypgtfgqgtkvev

  • Chain 'T':
    Sequence, based on SEQRES records:
    >6eduT (T:)
qihlvqsgtevkkpgssvtvsckaygvntfglyavnwvrqapgqsleyigqiwrwkssas
hhfrgrvlisavdltgssppissleiknltsddtavyfctttstydkwsglhhdgvmafs
swgqgtlisvsaastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgalts
gvhtfpavlqssglyslssvvtvpssslgtqtyicnvnhkpsntkvdkrvepkscdkthh
hhhh

    Sequence, based on observed residues (ATOM records):
    >6eduT (T:)
qihlvqsgtevkkpgssvtvsckaygvntfglyavnwvrqapgqsleyigqiwrwkssas
hhfrgrvlisavdltgssppissleiknltsddtavyfctttstydkwsglhhdgvmafs
swgqgtlisvs

  • Chain 'U':
    Sequence, based on SEQRES records:
    >6eduU (U:)
diqmtqspstlsasigdtvriscrasqsitgnwvawyqqrpgkaprlliyrgaallggvp
srfsgsaagtdftltignlqaedfgtfycqqydtypgtfgqgtkvevkrtvaapsvfifp
psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstl
tlskadyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records):
    >6eduU (U:)
diqmtqspstlsasigdtvriscrasqsitgnwvawyqqrpgkaprlliyrgaallggvp
srfsgsaagtdftltignlqaedfgtfycqqydtypgtfgqgtkvev