PDB entry 6eds

View 6eds on RCSB PDB site
Description: structure of cysteine-free human insulin-degrading enzyme in complex with glucagon and substrate-selective macrocyclic inhibitor 63
Deposited on 2018-08-10, released 2019-04-03
The last revision was dated 2019-05-29, with a file datestamp of 2019-05-24.
Experiment type: XRAY
Resolution: 3.18 Å
R-factor: N/A
AEROSPACI score: 0.12 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Insulin-degrading enzyme
    Species: Homo sapiens [TaxId:9606]
    Gene: IDE
    Database cross-references and differences (RAF-indexed):
    • Uniprot P14735
      • engineered mutation (68-69)
      • engineered mutation (129)
      • engineered mutation (136)
      • engineered mutation (215)
      • engineered mutation (372)
      • engineered mutation (531)
      • engineered mutation (548)
      • engineered mutation (747)
      • engineered mutation (770)
      • engineered mutation (777)
      • engineered mutation (862)
      • engineered mutation (924)
  • Chain 'B':
    Compound: Insulin-degrading enzyme
    Species: Homo sapiens [TaxId:9606]
    Gene: IDE
    Database cross-references and differences (RAF-indexed):
    • Uniprot P14735
      • engineered mutation (68-69)
      • engineered mutation (129)
      • engineered mutation (136)
      • engineered mutation (215)
      • engineered mutation (372)
      • engineered mutation (531)
      • engineered mutation (548)
      • engineered mutation (747)
      • engineered mutation (770)
      • engineered mutation (777)
      • engineered mutation (862)
      • engineered mutation (924)
  • Chain 'C':
    Compound: glucagon
    Species: Homo sapiens [TaxId:9606]
    Gene: GCG
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: glucagon
    Species: Homo sapiens [TaxId:9606]
    Gene: GCG
    Database cross-references and differences (RAF-indexed):
  • Heterogens: J22, EPE, PEG, DIO

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6edsA (A:)
mnnpaikrignhitkspedkreyrglelangikvllisdpttdkssaaldvhigslsdpp
niaglshflqhmlflgtkkypkeneysqflsehagssnaftsgehtnyyfdvshehlega
ldrfaqfflsplfdesakdrevnavdseheknvmndawrlfqlekatgnpkhpfskfgtg
nkytletrpnqegidvrqellkfhsayyssnlmavvvlgreslddltnlvvklfsevenk
nvplpefpehpfqeehlkqlykivpikdirnlyvtfpipdlqkyyksnpghylghlighe
gpgsllselkskgwvntlvggqkegargfmffiinvdlteegllhvediilhmfqyiqkl
raegpqewvfqelkdlnavafrfkdkerprgytskiagilhyypleevltaeylleefrp
dliemvldklrpenvrvaivsksfegktdrteewygtqykqeaipdevikkwqnadlngk
fklptknefiptnfeilplekeatpypalikdtamsklwfkqddkfflpkanlnfeffsp
fayvdplhsnmaylylellkdslneyayaaelaglsydlqntiygmylsvkgyndkqpil
lkkiiekmatfeidekrfeiikeaymrslnnfraeqphqhamyylrllmtevawtkdelk
ealddvtlprlkafipqllsrlhieallhgnitkqaalgimqmvedtliehahtkpllps
qlvryrevqlpdrgwfvyqqrnevhnnsgieiyyqtdmqstsenmflelfaqiisepafn
tlrtkeqlgyivfsgprrangiqglrfiiqsekpphylesrveaflitmeksiedmteea
fqkhiqalairrldkpkklsaesakywgeiisqqynfdrdntevaylktltkediikfyk
emlavdaprrhkvsvhvlaremdsnpvvgefpaqndinlsqapalpqpeviqnmtefkrg
lplfplvkphinfmaakl

    Sequence, based on observed residues (ATOM records):
    >6edsA (A:)
nnpaikrignhitkspedkreyrglelangikvllisdpttdkssaaldvhigslsdppn
iaglshflqhmlflgtkkypkeneysqflsehagssnaftsgehtnyyfdvshehlegal
drfaqfflsplfdesakdrevnavdseheknvmndawrlfqlekatgnpkhpfskfgtgn
kytletrpnqegidvrqellkfhsayyssnlmavvvlgreslddltnlvvklfsevenkn
vplpefpehpfqeehlkqlykivpikdirnlyvtfpipdlqkyyksnpghylghligheg
pgsllselkskgwvntlvggqkegargfmffiinvdlteegllhvediilhmfqyiqklr
aegpqewvfqelkdlnavafrfkdkerprgytskiagilhyypleevltaeylleefrpd
liemvldklrpenvrvaivsksfegktdrteewygtqykqeaipdevikkwqnadlngkf
klptknefiptnfeilplekeatpypalikdtamsklwfkqddkfflpkanlnfeffspf
ayvdplhsnmaylylellkdslneyayaaelaglsydlqntiygmylsvkgyndkqpill
kkiiekmatfeidekrfeiikeaymrslnnfraeqphqhamyylrllmtevawtkdelke
alddvtlprlkafipqllsrlhieallhgnitkqaalgimqmvedtliehahtkpllpsq
lvryrevqlpdrgwfvyqqrnevhnnsgieiyyqtdmqstsenmflelfaqiisepafnt
lrtkeqlgyivfsgprrangiqglrfiiqsekpphylesrveaflitmeksiedmteeaf
qkhiqalairrldkpkklsaesakywgeiisqqynfdrdntevaylktltkediikfyke
mlavdaprrhkvsvhvlaremdsnpinlsqapalpqpeviqnmtefkrglplfplvkph

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6edsB (B:)
mnnpaikrignhitkspedkreyrglelangikvllisdpttdkssaaldvhigslsdpp
niaglshflqhmlflgtkkypkeneysqflsehagssnaftsgehtnyyfdvshehlega
ldrfaqfflsplfdesakdrevnavdseheknvmndawrlfqlekatgnpkhpfskfgtg
nkytletrpnqegidvrqellkfhsayyssnlmavvvlgreslddltnlvvklfsevenk
nvplpefpehpfqeehlkqlykivpikdirnlyvtfpipdlqkyyksnpghylghlighe
gpgsllselkskgwvntlvggqkegargfmffiinvdlteegllhvediilhmfqyiqkl
raegpqewvfqelkdlnavafrfkdkerprgytskiagilhyypleevltaeylleefrp
dliemvldklrpenvrvaivsksfegktdrteewygtqykqeaipdevikkwqnadlngk
fklptknefiptnfeilplekeatpypalikdtamsklwfkqddkfflpkanlnfeffsp
fayvdplhsnmaylylellkdslneyayaaelaglsydlqntiygmylsvkgyndkqpil
lkkiiekmatfeidekrfeiikeaymrslnnfraeqphqhamyylrllmtevawtkdelk
ealddvtlprlkafipqllsrlhieallhgnitkqaalgimqmvedtliehahtkpllps
qlvryrevqlpdrgwfvyqqrnevhnnsgieiyyqtdmqstsenmflelfaqiisepafn
tlrtkeqlgyivfsgprrangiqglrfiiqsekpphylesrveaflitmeksiedmteea
fqkhiqalairrldkpkklsaesakywgeiisqqynfdrdntevaylktltkediikfyk
emlavdaprrhkvsvhvlaremdsnpvvgefpaqndinlsqapalpqpeviqnmtefkrg
lplfplvkphinfmaakl

    Sequence, based on observed residues (ATOM records):
    >6edsB (B:)
nnpaikrignhitkspedkreyrglelangikvllisdpttdkssaaldvhigslsdppn
iaglshflqhmlflgtkkypkeneysqflsehagssnaftsgehtnyyfdvshehlegal
drfaqfflsplfdesakdrevnavdseheknvmndawrlfqlekatgnpkhpfskfgtgn
kytletrpnqegidvrqellkfhsayyssnlmavvvlgreslddltnlvvklfsevenkn
vplpefpehpfqeehlkqlykivpikdirnlyvtfpipdlqkyyksnpghylghligheg
pgsllselkskgwvntlvggqkegargfmffiinvdlteegllhvediilhmfqyiqklr
aegpqewvfqelkdlnavafrfkdkerprgytskiagilhyypleevltaeylleefrpd
liemvldklrpenvrvaivsksfegktdrteewygtqykqeaipdevikkwqnadlngkf
klptknefiptnfeilplekeatpypalikdtamsklwfkqddkfflpkanlnfeffspf
ayvdplhsnmaylylellkdslneyayaaelaglsydlqntiygmylsvkgyndkqpill
kkiiekmatfeidekrfeiikeaymrslnnfraeqphqhamyylrllmtevawtkdelke
alddvtlprlkafipqllsrlhieallhgnitkqaalgimqmvedtliehahtkpllpsq
lvryrevqlpdrgwfvyqqrnevhnnsgieiyyqtdmqstsenmflelfaqiisepafnt
lrtkeqlgyivfsgprrangiqglrfiiqsekpphylesrveaflitmeksiedmteeaf
qkhiqalairrldkpkklsaesakywgeiisqqynfdrdntevaylktltkediikfyke
mlavdaprrhkvsvhvlaremdsnpinlsqapalpqpeviqnmtefkrglplfplvkph

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6edsC (C:)
hsqgtftsdyskyldsrraqdfvqwlmnt

    Sequence, based on observed residues (ATOM records):
    >6edsC (C:)
hsqgtfvqwlmn

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6edsD (D:)
hsqgtftsdyskyldsrraqdfvqwlmnt

    Sequence, based on observed residues (ATOM records):
    >6edsD (D:)
hsqgtfvqwlmn