PDB entry 6edr

View 6edr on RCSB PDB site
Description: Crystal Structure of Human CD38 in Complex with 4'-Thioribose NAD+
Class: hydrolase/hydrolase inhibitor
Keywords: Inhibitor, CD38, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2018-08-10, released 2018-11-21
The last revision prior to the SCOPe 2.07 freeze date was dated 2018-11-21, with a file datestamp of 2018-11-16.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: N/A
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: CD38
    Database cross-references and differences (RAF-indexed):
    • Uniprot P28907 (1-End)
      • expression tag (0)
      • engineered mutation (56)
      • engineered mutation (120)
      • engineered mutation (165)
      • engineered mutation (175)
    Domains in SCOPe 2.07: d6edra1, d6edra2
  • Chain 'B':
    Compound: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: CD38
    Database cross-references and differences (RAF-indexed):
    • Uniprot P28907 (1-End)
      • expression tag (0)
      • engineered mutation (56)
      • engineered mutation (120)
      • engineered mutation (165)
      • engineered mutation (175)
    Domains in SCOPe 2.07: d6edrb1, d6edrb2
  • Heterogens: ZNA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6edrA (A:)
srwrqqwsgpgttkrfpetvlarcvkyteihpemrhvdcqsvwdafkgafiskhpcdite
edyqplmklgtqtvpcnkillwsrikdlahqftqvqrdmftledtllgyladdltwcgef
atskinyqscpdwrkdcsnnpvsvfwktvsrrfaeaacdvvhvmldgsrskifdkdstfg
svevhnlqpekvqtleawvihggredsrdlcqdptikelesiiskrniqfsckniyrpdk
flqcvknpedssctsei

    Sequence, based on observed residues (ATOM records): (download) 
    >6edrA (A:)
srwrqqwsgpgttkrfpetvlarcvkyteihpemrhvdcqsvwdafkgafiskhpcdite
edyqplmklgtqtvpcnkillwsrikdlahqftqvqrdmftledtllgyladdltwcgef
atskinyqscpdwrkdcsnnpvsvfwktvsrrfaeaacdvvhvmldgsrskifdkdstfg
svevhnlqpekvqtleawvihggredsrdlcqdptikelesiiskrniqfsckniyrpdk
flqcvknpe

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6edrB (B:)
srwrqqwsgpgttkrfpetvlarcvkyteihpemrhvdcqsvwdafkgafiskhpcdite
edyqplmklgtqtvpcnkillwsrikdlahqftqvqrdmftledtllgyladdltwcgef
atskinyqscpdwrkdcsnnpvsvfwktvsrrfaeaacdvvhvmldgsrskifdkdstfg
svevhnlqpekvqtleawvihggredsrdlcqdptikelesiiskrniqfsckniyrpdk
flqcvknpedssctsei

    Sequence, based on observed residues (ATOM records): (download) 
    >6edrB (B:)
srwrqqwsgpgttkrfpetvlarcvkyteihpemrhvdcqsvwdafkgafiskhpcdite
edyqplmklgtqtvpcnkillwsrikdlahqftqvqrdmftledtllgyladdltwcgef
atskinyqscpdwrkdcsnnpvsvfwktvsrrfaeaacdvvhvmldgsrskifdkdstfg
svevhnlqpekvqtleawvihgdsrdlcqdptikelesiiskrniqfsckniyrpdkflq
cvknpe