PDB entry 6edl

View 6edl on RCSB PDB site
Description: hALK in complex with compound 1 (S)-N-(1-(2,4-difluorophenyl)ethyl)-3-(3-methyl-1H-pyrazol-5-yl)imidazo[1,2-b]pyridazin-6-amine
Class: transferase/inhibitor
Keywords: Inhibitor, complex, kinase, sbdd, TRANSFERASE-INHIBITOR complex
Deposited on 2018-08-09, released 2019-05-01
The last revision prior to the SCOPe 2.07 freeze date was dated 2019-05-01, with a file datestamp of 2019-04-26.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: N/A
AEROSPACI score: 0.16 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: ALK tyrosine kinase receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: ALK
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6edla_
  • Heterogens: J4M, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >6edlA (A:)
    gamgstdynpnycfagktssisdlkevprknitlirglghgafgevyegqvsgmpndpsp
    lqvavktlpevcseqdeldflmealiiskfnhqnivrcigvslqslprfillelmaggdl
    ksflretrprpsqpsslamldllhvardiacgcqyleenhfihrdiaarnclltcpgpgr
    vakigdfgmardiyrasyyrkggcamlpvkwmppeafmegiftsktdtwsfgvllweifs
    lgympypsksnqevlefvtsggrmdppkncpgpvyrimtqcwqhqpedrpnfaiilerie
    yctqdpdvintalpieygplve
    

    Sequence, based on observed residues (ATOM records): (download)
    >6edlA (A:)
    npnycfagktssisdlkevprknitlirglghgevyegqvssplqvavktlpevcseqde
    ldflmealiiskfnhqnivrcigvslqslprfillelmaggdlksflretrprpsqpssl
    amldllhvardiacgcqyleenhfihrdiaarnclltcpgpgrvakigdfcamlpvkwmp
    peafmegiftsktdtwsfgvllweifslgympypsksnqevlefvtsggrmdppkncpgp
    vyrimtqcwqhqpedrpnfaiilerieyctqdpdvintalpi