PDB entry 6eda
View 6eda on RCSB PDB site
Description: Bioreductive 4-hydroxy-3-nitro-5-ureido-benzenesulfonamides selectively target the tumor-associated carbonic anhydrase isoforms IX and XII and show hypoxia-enhanced cytotoxicity against human cancer cell lines.
Class: lyase/lyase inhibitor
Keywords: Hypoxia, carbonic anhydrase IX, carbonic anhydrase XII, inhibition, anti-proliferative., LYASE, LYASE-LYASE INHIBITOR complex
Deposited on
2018-08-09, released
2018-11-28
The last revision prior to the SCOPe 2.08 freeze date was dated
2019-05-01, with a file datestamp of
2019-04-26.
Experiment type: XRAY
Resolution: 1.88 Å
R-factor: N/A
AEROSPACI score: 0.35
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Carbonic anhydrase 2
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d6edaa_ - Heterogens: J3V, ZN, HOH