PDB entry 6ecr

View 6ecr on RCSB PDB site
Description: The human methylenetetrahydrofolate dehydrogenase/cyclohydrolase (FolD) complexed with NADP
Class: oxidoreductase
Keywords: dehydrogenase, cyclohydrolase, bifunctional protein, OXIDOREDUCTASE
Deposited on 2018-08-08, released 2019-03-27
The last revision prior to the SCOPe 2.07 freeze date was dated 2019-03-27, with a file datestamp of 2019-03-22.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: N/A
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: methylenetetrahydrofolate dehydrogenase cyclohydrolase
    Species: Homo sapiens [TaxId:9606]
    Gene: MTHFD1, MTHFC, MTHFD
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6ecra1, d6ecra2
  • Chain 'B':
    Compound: methylenetetrahydrofolate dehydrogenase cyclohydrolase
    Species: Homo sapiens [TaxId:9606]
    Gene: MTHFD1, MTHFC, MTHFD
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6ecrb1, d6ecrb2
  • Heterogens: NAP, ACT, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6ecrA (A:)
mapaeilngkeisaqirarlknqvtqlkeqvpgftprlailqvgnrddsnlyinvklkaa
eeigikathiklprtttesevmkyitslnedstvhgflvqlpldsensinteevinaiap
ekdvdgltsinagrlargdlndcfipctpkgcleliketgvpiagrhavvvgrskivgap
mhdlllwnnatvttchsktahldeevnkgdilvvatgqpemvkgewikpgaividcginy
vpddkkpngrkvvgdvaydeakerasfitpvpggvgpmtvamlmqstvesakrfle

    Sequence, based on observed residues (ATOM records): (download) 
    >6ecrA (A:)
apaeilngkeisaqirarlknqvtqlkeqvpgftprlailqvgnrddsnlyinvklkaae
eigikathiklprtttesevmkyitslnedstvhgflvqlpldsensinteevinaiape
kdvdgltsinagrlargdlndcfipctpkgcleliketgvpiagrhavvvgrskivgapm
hdlllwnnatvttchsktahldeevnkgdilvvatgqpemvkgewikpgaividcginyk
vvgdvaydeakerasfitpvpggvgpmtvamlmqstvesakrfle

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6ecrB (B:)
mapaeilngkeisaqirarlknqvtqlkeqvpgftprlailqvgnrddsnlyinvklkaa
eeigikathiklprtttesevmkyitslnedstvhgflvqlpldsensinteevinaiap
ekdvdgltsinagrlargdlndcfipctpkgcleliketgvpiagrhavvvgrskivgap
mhdlllwnnatvttchsktahldeevnkgdilvvatgqpemvkgewikpgaividcginy
vpddkkpngrkvvgdvaydeakerasfitpvpggvgpmtvamlmqstvesakrfle

    Sequence, based on observed residues (ATOM records): (download) 
    >6ecrB (B:)
apaeilngkeisaqirarlknqvtqlkeqvpgftprlailqvgnrddsnlyinvklkaae
eigikathiklprtttesevmkyitslnedstvhgflvqlpldsensinteevinaiape
kdvdgltsinagrlargdlndcfipctpkgcleliketgvpiagrhavvvgrskivgapm
hdlllwnnatvttchsktahldeevnkgdilvvatgqpemvkgewikpgaividcginyv
pddkkpngrkvvgdvaydeakerasfitpvpggvgpmtvamlmqstvesakrfle