PDB entry 6ecq

View 6ecq on RCSB PDB site
Description: The human methylenetetrahydrofolate dehydrogenase/cyclohydrolase (FolD) complexed with NADP and inhibitor LY345899
Class: oxidoreductase
Keywords: dehydrogenase, cyclohydrolase, bifunctional protein, OXIDOREDUCTASE
Deposited on 2018-08-08, released 2019-03-27
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-01-01, with a file datestamp of 2019-12-27.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: N/A
AEROSPACI score: 0.18 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: methylenetetrahydrofolate dehydrogenase cyclohydrolase
    Species: Homo sapiens [TaxId:9606]
    Gene: MTHFD1, MTHFC, MTHFD
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6ecqa1, d6ecqa2
  • Chain 'B':
    Compound: methylenetetrahydrofolate dehydrogenase cyclohydrolase
    Species: Homo sapiens [TaxId:9606]
    Gene: MTHFD1, MTHFC, MTHFD
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6ecqb1, d6ecqb2
  • Heterogens: NAP, LUD, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6ecqA (A:)
mapaeilngkeisaqirarlknqvtqlkeqvpgftprlailqvgnrddsnlyinvklkaa
eeigikathiklprtttesevmkyitslnedstvhgflvqlpldsensinteevinaiap
ekdvdgltsinagrlargdlndcfipctpkgcleliketgvpiagrhavvvgrskivgap
mhdlllwnnatvttchsktahldeevnkgdilvvatgqpemvkgewikpgaividcginy
vpddkkpngrkvvgdvaydeakerasfitpvpggvgpmtvamlmqstvesakrfle

    Sequence, based on observed residues (ATOM records): (download) 
    >6ecqA (A:)
apaeilngkeisaqirarlknqvtqlkeqvpgftprlailqvgnrddsnlyinvklkaae
eigikathiklprtttesevmkyitslnedstvhgflvqlpldsensinteevinaiape
kdvdgltsinagrlargdlndcfipctpkgcleliketgvpiagrhavvvgrskivgapm
hdlllwnnatvttchsktahldeevnkgdilvvatgqpemvkgewikpgaividcginyv
pkvvgdvaydeakerasfitpvpggvgpmtvamlmqstvesakrfle

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6ecqB (B:)
mapaeilngkeisaqirarlknqvtqlkeqvpgftprlailqvgnrddsnlyinvklkaa
eeigikathiklprtttesevmkyitslnedstvhgflvqlpldsensinteevinaiap
ekdvdgltsinagrlargdlndcfipctpkgcleliketgvpiagrhavvvgrskivgap
mhdlllwnnatvttchsktahldeevnkgdilvvatgqpemvkgewikpgaividcginy
vpddkkpngrkvvgdvaydeakerasfitpvpggvgpmtvamlmqstvesakrfle

    Sequence, based on observed residues (ATOM records): (download) 
    >6ecqB (B:)
apaeilngkeisaqirarlknqvtqlkeqvpgftprlailqvgnrddsnlyinvklkaae
eigikathiklprtttesevmkyitslnedstvhgflvqlpldsensinteevinaiape
kdvdgltsinagrlargdlndcfipctpkgcleliketgvpiagrhavvvgrskivgapm
hdlllwnnatvttchsktahldeevnkgdilvvatgqpemvkgewikpgaividcginyv
pddkkpngrkvvgdvaydeakerasfitpvpggvgpmtvamlmqstvesakrfle