PDB entry 6ebs

View 6ebs on RCSB PDB site
Description: Crystal structure of Leishmania major dihydroorotate dehydrogenase mutant H174A in complex with orotate
Class: oxidoreductase
Keywords: dihydroorotate dehydrogenase, Leishmania major, mutant H174A, OXIDOREDUCTASE
Deposited on 2018-08-07, released 2019-08-21
The last revision prior to the SCOPe 2.07 freeze date was dated 2019-08-21, with a file datestamp of 2019-08-16.
Experiment type: XRAY
Resolution: 2.05 Å
R-factor: N/A
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Dihydroorotate dehydrogenase (fumarate)
    Species: Leishmania major [TaxId:5664]
    Gene: DHODH, LMJF_16_0530
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q4QEW7 (34-End)
      • expression tag (33)
      • engineered mutation (207)
    Domains in SCOPe 2.07: d6ebsa1, d6ebsa2
  • Chain 'B':
    Compound: Dihydroorotate dehydrogenase (fumarate)
    Species: Leishmania major [TaxId:5664]
    Gene: DHODH, LMJF_16_0530
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q4QEW7 (34-End)
      • expression tag (33)
      • engineered mutation (207)
    Domains in SCOPe 2.07: d6ebsb1, d6ebsb2
  • Heterogens: FMN, ORO, GOL, SO4, NI, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >6ebsA (A:)
    mgsshhhhhhssglvpagshmasmtggqqmgrgsmslqvnllnntfanpfmnaagvmctt
    teelvamtesasgslvsksctpalregnptpryqalplgsinsmglpnngfdfylayaae
    qhdygkkplflsmsglsmrenvemckrlaavatekgvilelnlscpnvpgkpqvaydfda
    mrqcltavsevyphsfgvkmppyfdfaafdaaaeilnefpkvqfitcinsignglvidae
    tesvvikpkqgfgglggryvlptalaninafyrrcpgklifgcggvytgedaflhvlaga
    smvqvgtalqeegpsiferltsellgvmakkryqtldefrgkvrtldgtaestr
    

    Sequence, based on observed residues (ATOM records): (download)
    >6ebsA (A:)
    smslqvnllnntfanpfmnaagvmcttteelvamtesasgslvsksctpalregnptpry
    qalplgsinsmglpnngfdfylayaaeqhdygkkplflsmsglsmrenvemckrlaavat
    ekgvilelnlscpnvpgkpqvaydfdamrqcltavsevyphsfgvkmppyfdfaafdaaa
    eilnefpkvqfitcinsignglvidaetesvvikpkqgfgglggryvlptalaninafyr
    rcpgklifgcggvytgedaflhvlagasmvqvgtalqeegpsiferltsellgvmakkry
    qtldefrgkvrtl
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >6ebsB (B:)
    mgsshhhhhhssglvpagshmasmtggqqmgrgsmslqvnllnntfanpfmnaagvmctt
    teelvamtesasgslvsksctpalregnptpryqalplgsinsmglpnngfdfylayaae
    qhdygkkplflsmsglsmrenvemckrlaavatekgvilelnlscpnvpgkpqvaydfda
    mrqcltavsevyphsfgvkmppyfdfaafdaaaeilnefpkvqfitcinsignglvidae
    tesvvikpkqgfgglggryvlptalaninafyrrcpgklifgcggvytgedaflhvlaga
    smvqvgtalqeegpsiferltsellgvmakkryqtldefrgkvrtldgtaestr
    

    Sequence, based on observed residues (ATOM records): (download)
    >6ebsB (B:)
    smslqvnllnntfanpfmnaagvmcttteelvamtesasgslvsksctpalregnptpry
    qalplgsinsmglpnngfdfylayaaeqhdygkkplflsmsglsmrenvemckrlaavat
    ekgvilelnlscpnvpgkpqvaydfdamrqcltavsevyphsfgvkmppyfdfaafdaaa
    eilnefpkvqfitcinsignglvidaetesvvikpkqgfgglggryvlptalaninafyr
    rcpgklifgcggvytgedaflhvlagasmvqvgtalqeegpsiferltsellgvmakkry
    qtldefrgkvrtl