PDB entry 6dwn

View 6dwn on RCSB PDB site
Description: Structure of Human Cytochrome P450 1A1 with Erlotinib
Class: oxidoreductase
Keywords: ligand, OXIDOREDUCTASE
Deposited on 2018-06-26, released 2018-10-03
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-01-01, with a file datestamp of 2019-12-27.
Experiment type: XRAY
Resolution: 3 Å
R-factor: N/A
AEROSPACI score: 0.15 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cytochrome P450 1A1
    Species: Homo sapiens [TaxId:9606]
    Gene: CYP1A1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6dwna_
  • Chain 'B':
    Compound: Cytochrome P450 1A1
    Species: Homo sapiens [TaxId:9606]
    Gene: CYP1A1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6dwnb_
  • Chain 'C':
    Compound: Cytochrome P450 1A1
    Species: Homo sapiens [TaxId:9606]
    Gene: CYP1A1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6dwnc_
  • Chain 'D':
    Compound: Cytochrome P450 1A1
    Species: Homo sapiens [TaxId:9606]
    Gene: CYP1A1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6dwnd_
  • Heterogens: HEM, AQ4, CPS, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6dwnA (A:)
makktsskglknppgpwgwplighmltlgknphlalsrmsqqygdvlqirigstpvvvls
gldtirqalvrqgddfkgrpdlytftlisngqsmsfspdsgpvwaarrrlaqnglksfsi
asdpasstscyleehvskeaevlistlqelmagpghfnpyryvvvsvtnvicaicfgrry
dhnhqellslvnlnnnfgevvgsgnpadfipilrylpnpslnafkdlnekfysfmqkmvk
ehyktfekghirditdsliehcqekqldenanvqlsdekiinivldlfgagfdtvttais
wslmylvmnprvqrkiqeeldtvigrsrrprlsdrshlpymeafiletfrhssfvpftip
hsttrdtslkgfyipkgrcvfvnqwqinhdqklwvnpseflperfltpdgaidkvlsekv
iifgmgkrkcigetiarwevflflaillqrvefsvplgvkvdmtpiygltmkhaccehfq
mqlrshhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6dwnA (A:)
lknppgpwgwplighmltlgknphlalsrmsqqygdvlqirigstpvvvlsgldtirqal
vrqgddfkgrpdlytftlisngqsmsfspdsgpvwaarrrlaqnglksfsiasdpassts
cyleehvskeaevlistlqelmagpghfnpyryvvvsvtnvicaicfgrrydhnhqells
lvnlnnnfgevvgsgnpadfipilrylpnpslnafkdlnekfysfmqkmvkehyktfekg
hirditdsliehcqekqldenanvqlsdekiinivldlfgagfdtvttaiswslmylvmn
prvqrkiqeeldtvigrsrrprlsdrshlpymeafiletfrhssfvpftiphsttrdtsl
kgfyipkgrcvfvnqwqinhdqklwvnpseflperfltpdgaidkvlsekviifgmgkrk
cigetiarwevflflaillqrvefsvplgvkvdmtpiygltmkhaccehfqmqlrs

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6dwnB (B:)
makktsskglknppgpwgwplighmltlgknphlalsrmsqqygdvlqirigstpvvvls
gldtirqalvrqgddfkgrpdlytftlisngqsmsfspdsgpvwaarrrlaqnglksfsi
asdpasstscyleehvskeaevlistlqelmagpghfnpyryvvvsvtnvicaicfgrry
dhnhqellslvnlnnnfgevvgsgnpadfipilrylpnpslnafkdlnekfysfmqkmvk
ehyktfekghirditdsliehcqekqldenanvqlsdekiinivldlfgagfdtvttais
wslmylvmnprvqrkiqeeldtvigrsrrprlsdrshlpymeafiletfrhssfvpftip
hsttrdtslkgfyipkgrcvfvnqwqinhdqklwvnpseflperfltpdgaidkvlsekv
iifgmgkrkcigetiarwevflflaillqrvefsvplgvkvdmtpiygltmkhaccehfq
mqlrshhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6dwnB (B:)
glknppgpwgwplighmltlgknphlalsrmsqqygdvlqirigstpvvvlsgldtirqa
lvrqgddfkgrpdlytftlisngqsmsfspdsgpvwaarrrlaqnglksfsiasdpasst
scyleehvskeaevlistlqelmagpghfnpyryvvvsvtnvicaicfgrrydhnhqell
slvnlnnnfgevvgsgnpadfipilrylpnpslnafkdlnekfysfmqkmvkehyktfek
ghirditdsliehcqsdekiinivldlfgagfdtvttaiswslmylvmnprvqrkiqeel
dtvigrsrrprlsdrshlpymeafiletfrhssfvpftiphsttrdtslkgfyipkgrcv
fvnqwqinhdqklwvnpseflperfltpdgaidkvlsekviifgmgkrkcigetiarwev
flflaillqrvefsvplgvkvdmtpiygltmkhaccehfqmqlrs

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6dwnC (C:)
makktsskglknppgpwgwplighmltlgknphlalsrmsqqygdvlqirigstpvvvls
gldtirqalvrqgddfkgrpdlytftlisngqsmsfspdsgpvwaarrrlaqnglksfsi
asdpasstscyleehvskeaevlistlqelmagpghfnpyryvvvsvtnvicaicfgrry
dhnhqellslvnlnnnfgevvgsgnpadfipilrylpnpslnafkdlnekfysfmqkmvk
ehyktfekghirditdsliehcqekqldenanvqlsdekiinivldlfgagfdtvttais
wslmylvmnprvqrkiqeeldtvigrsrrprlsdrshlpymeafiletfrhssfvpftip
hsttrdtslkgfyipkgrcvfvnqwqinhdqklwvnpseflperfltpdgaidkvlsekv
iifgmgkrkcigetiarwevflflaillqrvefsvplgvkvdmtpiygltmkhaccehfq
mqlrshhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6dwnC (C:)
knppgpwgwplighmltlgknphlalsrmsqqygdvlqirigstpvvvlsgldtirqalv
rqgddfkgrpdlytftlisngqsmsfspdsgpvwaarrrlaqnglksfsiasdpasstsc
yleehvskeaevlistlqelmagpghfnpyryvvvsvtnvicaicfgrrydhnhqellsl
vnlnnnfgevvgsgnpadfipilrylpnpslnafkdlnekfysfmqkmvkehyktfekgh
irditdsliehcsdekiinivldlfgagfdtvttaiswslmylvmnprvqrkiqeeldtv
igrsrrprlsdrshlpymeafiletfrhssfvpftiphsttrdtslkgfyipkgrcvfvn
qwqinhdqklwvnpseflperfltpdgaidkvlsekviifgmgkrkcigetiarwevflf
laillqrvefsvplgvkvdmtpiygltmkhaccehfqmqlrs

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6dwnD (D:)
makktsskglknppgpwgwplighmltlgknphlalsrmsqqygdvlqirigstpvvvls
gldtirqalvrqgddfkgrpdlytftlisngqsmsfspdsgpvwaarrrlaqnglksfsi
asdpasstscyleehvskeaevlistlqelmagpghfnpyryvvvsvtnvicaicfgrry
dhnhqellslvnlnnnfgevvgsgnpadfipilrylpnpslnafkdlnekfysfmqkmvk
ehyktfekghirditdsliehcqekqldenanvqlsdekiinivldlfgagfdtvttais
wslmylvmnprvqrkiqeeldtvigrsrrprlsdrshlpymeafiletfrhssfvpftip
hsttrdtslkgfyipkgrcvfvnqwqinhdqklwvnpseflperfltpdgaidkvlsekv
iifgmgkrkcigetiarwevflflaillqrvefsvplgvkvdmtpiygltmkhaccehfq
mqlrshhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6dwnD (D:)
knppgpwgwplighmltlgknphlalsrmsqqygdvlqirigstpvvvlsgldtirqalv
rqgddfkgrpdlytftlisngqsmsfspdsgpvwaarrrlaqnglksfsiasdpasstsc
yleehvskeaevlistlqelmagpghfnpyryvvvsvtnvicaicfgrryvnlnnnfgev
vgsgnpadfipilrylpnpslnafkdlnekfysfmqkmvkehyktfekghirditdslie
hcqsdekiinivldlfgagfdtvttaiswslmylvmnprvqrkiqeeldtvigrsrrprl
sdrshlpymeafiletfrhssfvpftiphsttrdtslkgfyipkgrcvfvnqwqinhdqk
lwvnpseflperfltpdgaidkvlsekviifgmgkrkcigetiarwevflflaillqrve
fsvplgvkvdmtpiygltmkhaccehfqmqlrs