PDB entry 6dvr

View 6dvr on RCSB PDB site
Description: Crystal structure of human CARM1 with (R)-SKI-72
Class: transferase/transferase inhibitor
Keywords: CARM1, PRMT4, SKI-72 inhibitor, Structural Genomics, Structural Genomics Consortium, SGC, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2018-06-25, released 2018-07-25
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-07-25, with a file datestamp of 2018-07-20.
Experiment type: XRAY
Resolution: 1.54 Å
R-factor: N/A
AEROSPACI score: 0.46 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: histone-arginine methyltransferase carm1
    Species: Homo sapiens [TaxId:9606]
    Gene: Carm1, Prmt4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6dvra_
  • Chain 'B':
    Compound: histone-arginine methyltransferase carm1
    Species: Homo sapiens [TaxId:9606]
    Gene: Carm1, Prmt4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6dvrb_
  • Heterogens: HDG, P15, UNX, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6dvrA (A:)
avqyfqfygylsqqqnmmqdyvrtgtyqrailqnhtdfkdkivldvgcgsgilsffaaqa
garkiyaveastmaqhaevlvksnnltdrivvipgkveevslpeqvdiiisepmgymlfn
ermlesylhakkylkpsgnmfptigdvhlapftdeqlymeqftkanfwyqpsfhgvdlsa
lrgaavdeyfrqpvvdtfdirilmaksvkytvnfleakegdlhrieipfkfhmlhsglvh
glafwfdvafigsimtvwlstapteplthwyqvrclfqsplfakagdtlsgtclliankr
qsydisivaqvdqtgskssnlldlknpffrytgttpspppgshy

    Sequence, based on observed residues (ATOM records): (download) 
    >6dvrA (A:)
qyfqfygylsqqqnmmqdyvrtgtyqrailqnhtdfkdkivldvgcgsgilsffaaqaga
rkiyaveastmaqhaevlvksnnltdrivvipgkveevslpeqvdiiisepmgymlfner
mlesylhakkylkpsgnmfptigdvhlapftdeqlymeqftkanfwyqpsfhgvdlsalr
gaavdeyfrqpvvdtfdirilmaksvkytvnfleakegdlhrieipfkfhmlhsglvhgl
afwfdvafigsimtvwlstapteplthwyqvrclfqsplfakagdtlsgtclliankrqs
ydisivaqvdqtgskssnlldlknpffrytgttpspp

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6dvrB (B:)
avqyfqfygylsqqqnmmqdyvrtgtyqrailqnhtdfkdkivldvgcgsgilsffaaqa
garkiyaveastmaqhaevlvksnnltdrivvipgkveevslpeqvdiiisepmgymlfn
ermlesylhakkylkpsgnmfptigdvhlapftdeqlymeqftkanfwyqpsfhgvdlsa
lrgaavdeyfrqpvvdtfdirilmaksvkytvnfleakegdlhrieipfkfhmlhsglvh
glafwfdvafigsimtvwlstapteplthwyqvrclfqsplfakagdtlsgtclliankr
qsydisivaqvdqtgskssnlldlknpffrytgttpspppgshy

    Sequence, based on observed residues (ATOM records): (download) 
    >6dvrB (B:)
qyfqfygylsqqqnmmqdyvrtgtyqrailqnhtdfkdkivldvgcgsgilsffaaqaga
rkiyaveastmaqhaevlvksnnltdrivvipgkveevslpeqvdiiisepmgymlfner
mlesylhakkylkpsgnmfptigdvhlapftdeqlymeqftkanfwyqpsfhgvdlsalr
gaavdeyfrqpvvdtfdirilmaksvkytvnfleakegdlhrieipfkfhmlhsglvhgl
afwfdvafigsimtvwlstapteplthwyqvrclfqsplfakagdtlsgtclliankrqs
ydisivaqvdqtgskssnlldlknpffryt