PDB entry 6dn0

View 6dn0 on RCSB PDB site
Description: Retrofitted antibodies with stabilizing mutations: Herceptin scFv mutant with VH K30D and VL S52D.
Class: immune system
Keywords: Herceptin, retrofit, stabilizing mutation, IMMUNE SYSTEM
Deposited on 2018-06-05, released 2019-06-12
The last revision prior to the SCOPe 2.07 freeze date was dated 2019-06-12, with a file datestamp of 2019-06-07.
Experiment type: XRAY
Resolution: 2 Å
R-factor: N/A
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Human Variable Heavy Chain of Herceptin containing VH mutation K30D
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6DN0 (0-End)
    Domains in SCOPe 2.07: d6dn0a_
  • Chain 'B':
    Compound: Human Variable Light Chain of Herceptin containing VL mutation S52D
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6DN0 (0-105)
    Domains in SCOPe 2.07: d6dn0b_
  • Chain 'C':
    Compound: Human Variable Heavy Chain of Herceptin containing VH mutation K30D
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6DN0 (0-End)
    Domains in SCOPe 2.07: d6dn0c_
  • Chain 'D':
    Compound: Human Variable Light Chain of Herceptin containing VL mutation S52D
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6DN0 (0-105)
    Domains in SCOPe 2.07: d6dn0d_
  • Heterogens: FMT, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6dn0A (A:)
evqlvesggglvqpggslrlscaasgfniddtyihwvrqapgkglewvariyptngytry
adsvkgrftisadtskntaylqmnslraedtavyycsrwggdgfyamdvwgqgtlvtvss
ggggsggggsggggst

    Sequence, based on observed residues (ATOM records): (download) 
    >6dn0A (A:)
evqlvesggglvqpggslrlscaasgfniddtyihwvrqapgkglewvariyptngytry
adsvkgrftisadtskntaylqmnslraedtavyycsrwggdgfyamdvwgqgtlvtvs

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6dn0B (B:)
diqmtqspsslsasvgdrvtitcrasqdvntavawyqqkpgkapklliysadflysgvps
rfsgsrsgtdftltisslqpedfatyycqqhyttpptfgqgtkvei

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6dn0C (C:)
evqlvesggglvqpggslrlscaasgfniddtyihwvrqapgkglewvariyptngytry
adsvkgrftisadtskntaylqmnslraedtavyycsrwggdgfyamdvwgqgtlvtvss
ggggsggggsggggst

    Sequence, based on observed residues (ATOM records): (download) 
    >6dn0C (C:)
evqlvesggglvqpggslrlscaasgfniddtyihwvrqapgkglewvariyptngytry
adsvkgrftisadtskntaylqmnslraedtavyycsrwgfyamdvwgqgtlvtvs

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6dn0D (D:)
diqmtqspsslsasvgdrvtitcrasqdvntavawyqqkpgkapklliysadflysgvps
rfsgsrsgtdftltisslqpedfatyycqqhyttpptfgqgtkvei