PDB entry 6dav

View 6dav on RCSB PDB site
Description: Crystal Structure of Human DHFR complexed with NADP and N10formyltetrahydrofolate
Class: oxidoreductase
Keywords: Structure-guided Drug Discovery Consortium, dihydrofolate reductase, hDHFR, NADP, OXIDOREDUCTASE
Deposited on 2018-05-02, released 2018-05-16
The last revision prior to the SCOPe 2.07 freeze date was dated 2018-05-16, with a file datestamp of 2018-05-11.
Experiment type: XRAY
Resolution: 1.55 Å
R-factor: N/A
AEROSPACI score: 0.46 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: dihydrofolate reductase
    Species: Homo sapiens [TaxId:9606]
    Gene: Dhfr
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6dava_
  • Chain 'B':
    Compound: dihydrofolate reductase
    Species: Homo sapiens [TaxId:9606]
    Gene: Dhfr
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6davb_
  • Heterogens: NAP, G3V, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >6davA (A:)
    mvgslncivavsqnmgigkngdlpwpplrnefryfqrmtttssvegkqnlvimgkktwfs
    ipeknrplkgrinlvlsrelkeppqgahflsrslddalklteqpelankvdmvwivggss
    vykeamnhpghlklfvtrimqdfesdtffpeidlekykllpeypgvlsdvqeekgikykf
    evyeknd
    

    Sequence, based on observed residues (ATOM records): (download)
    >6davA (A:)
    vgslncivavsqnmgigkngdlpwpplrnefryfqrmtttssvegkqnlvimgkktwfsi
    peknrplkgrinlvlsrelkeppqgahflsrslddalklteqpelankvdmvwivggssv
    ykeamnhpghlklfvtrimqdfesdtffpeidlekykllpeypgvlsdvqeekgikykfe
    vyeknd
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >6davB (B:)
    mvgslncivavsqnmgigkngdlpwpplrnefryfqrmtttssvegkqnlvimgkktwfs
    ipeknrplkgrinlvlsrelkeppqgahflsrslddalklteqpelankvdmvwivggss
    vykeamnhpghlklfvtrimqdfesdtffpeidlekykllpeypgvlsdvqeekgikykf
    evyeknd
    

    Sequence, based on observed residues (ATOM records): (download)
    >6davB (B:)
    vgslncivavsqnmgigkngdlpwpplrnefryfqrmtttssvegkqnlvimgkktwfsi
    peknrplkgrinlvlsrelkeppqgahflsrslddalklteqpelankvdmvwivggssv
    ykeamnhpghlklfvtrimqdfesdtffpeidlekykllpeypgvlsdvqeekgikykfe
    vyeknd