PDB entry 6d8z

View 6d8z on RCSB PDB site
Description: Crystal Structure of the C-terminal Guanine Exchange Factor Module of Human Trio
Class: signaling protein
Keywords: RhoGEF, Dbl Family member, Dbl Homology, Pleckstrin Homology, SIGNALING PROTEIN
Deposited on 2018-04-27, released 2019-02-20
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-12-04, with a file datestamp of 2019-11-29.
Experiment type: XRAY
Resolution: 2.65 Å
R-factor: N/A
AEROSPACI score: 0.19 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: triple functional domain protein
    Species: Homo sapiens [TaxId:9606]
    Gene: TRIO
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6d8za1, d6d8za2
  • Chain 'B':
    Compound: triple functional domain protein
    Species: Homo sapiens [TaxId:9606]
    Gene: TRIO
    Database cross-references and differences (RAF-indexed):
    • Uniprot O75962 (3-End)
      • cloning artifact (2)
    Domains in SCOPe 2.08: d6d8zb1, d6d8zb2, d6d8zb3
  • Chain 'C':
    Compound: triple functional domain protein
    Species: Homo sapiens [TaxId:9606]
    Gene: TRIO
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6d8zc1, d6d8zc2
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6d8zA (A:)
gefeerkssslkrrhyvlqelveterdyvrdlgyvvegymalmkedgvpddmkgkdkivf
gnihqiydwhrdfflgelekcledpeklgslfvkherrlhmyiaycqnkpksehivseyi
dtffedlkqrlghrlqltdllikpvqrimkyqlllkdflkyskkasldtseleravevmc
ivprrcndmmnvgrlqgfdgkivaqgklllqdtflvtdqdagllprcrerriflfeqivi
fsepldkkkgfsmpgflfknsikvsclcleenvendpckfaltsrtgdvvetfilhsssp
svrqtwiheinqilenqrn

    Sequence, based on observed residues (ATOM records): (download) 
    >6d8zA (A:)
lkrrhyvlqelveterdyvrdlgyvvegymalmkedgvpddmkgkdkivfgnihqiydwh
rdfflgelekcledpeklgslfvkherrlhmyiaycqnkpksehivseyidtffedlkqr
lghrlqltdllikpvqrimkyqlllkdflkyskkasldtseleravevmcivprrcndmm
nvgrlqgfdgkivaqgklllqdtflvtdrcrerriflfeqivifsepldkkkgfsmpgfl
fknsikvsclcleenvendpckfaltsrtgdvvetfilhssspsvrqtwiheinqilenq

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6d8zB (B:)
gefeerkssslkrrhyvlqelveterdyvrdlgyvvegymalmkedgvpddmkgkdkivf
gnihqiydwhrdfflgelekcledpeklgslfvkherrlhmyiaycqnkpksehivseyi
dtffedlkqrlghrlqltdllikpvqrimkyqlllkdflkyskkasldtseleravevmc
ivprrcndmmnvgrlqgfdgkivaqgklllqdtflvtdqdagllprcrerriflfeqivi
fsepldkkkgfsmpgflfknsikvsclcleenvendpckfaltsrtgdvvetfilhsssp
svrqtwiheinqilenqrn

    Sequence, based on observed residues (ATOM records): (download) 
    >6d8zB (B:)
feerkssslkrrhyvlqelveterdyvrdlgyvvegymalmkedgvpddmkgkdkivfgn
ihqiydwhrdfflgelekcledpeklgslfvkherrlhmyiaycqnkpksehivseyidt
ffedlkqrlghrlqltdllikpvqrimkyqlllkdflkyskkasldtseleravevmciv
prrcndmmnvgrlqgfdgkivaqgklllqdtflvtdqrcrerriflfeqivifsepldkk
kgfsmpgflfknsikvsclcleenvendpckfaltsrtgdvvetfilhssspsvrqtwih
einqilen

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6d8zC (C:)
gefeerkssslkrrhyvlqelveterdyvrdlgyvvegymalmkedgvpddmkgkdkivf
gnihqiydwhrdfflgelekcledpeklgslfvkherrlhmyiaycqnkpksehivseyi
dtffedlkqrlghrlqltdllikpvqrimkyqlllkdflkyskkasldtseleravevmc
ivprrcndmmnvgrlqgfdgkivaqgklllqdtflvtdqdagllprcrerriflfeqivi
fsepldkkkgfsmpgflfknsikvsclcleenvendpckfaltsrtgdvvetfilhsssp
svrqtwiheinqilenqrn

    Sequence, based on observed residues (ATOM records): (download) 
    >6d8zC (C:)
rrhyvlqelveterdyvrdlgyvvegymalmkedgvpddmkgkdkivfgnihqiydwhrd
fflgelekcledpeklgslfvkherrlhmyiaycqnkpksehivseyidtffedlkqrlg
hrlqltdllikpvqrimkyqlllkdflkyskkasldtseleravevmcivprrcndmmnv
grlqgfdgkivaqgklllqdtflvtdqrcrerriflfeqivifsepldkkkgfsmpgflf
knsikvsclcleenvendpckfaltsrtgdvvetfilhssspsvrqtwiheinqilenq