PDB entry 6d59

View 6d59 on RCSB PDB site
Description: Ras:SOS:Ras in complex with a small molecule activator
Class: signaling protein
Keywords: Ras, SOS, inhibitor, ONCOPROTEIN, Protein-protein complex, MAPK, SIGNALING PROTEIN
Deposited on 2018-04-19, released 2018-09-19
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-11-07, with a file datestamp of 2018-11-02.
Experiment type: XRAY
Resolution: 1.7 Å
R-factor: N/A
AEROSPACI score: 0.41 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: gtpase hras
    Species: Homo sapiens [TaxId:9606]
    Gene: HRAS, HRAS1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01112 (1-166)
      • conflict (64)
    Domains in SCOPe 2.08: d6d59a_
  • Chain 'B':
    Compound: Son of sevenless homolog 1
    Species: Homo sapiens [TaxId:9606]
    Gene: SOS1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q07889 (1-481)
      • expression tag (0)
    Domains in SCOPe 2.08: d6d59b1, d6d59b2
  • Chain 'C':
    Compound: gtpase hras
    Species: Homo sapiens [TaxId:9606]
    Gene: HRAS, HRAS1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01112 (1-166)
      • expression tag (0)
    Domains in SCOPe 2.08: d6d59c1, d6d59c2
  • Heterogens: GNP, MG, FVJ, FMT, GOL, NA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6d59A (A:)
gmteyklvvvgaggvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldildta
gqeeasamrdqymrtgegflcvfainntksfedihqyreqikrvkdsddvpmvlvgnkcd
laartvesrqaqdlarsygipyietsaktrqgvedafytlvreirqh

    Sequence, based on observed residues (ATOM records): (download) 
    >6d59A (A:)
mteyklvvvgaggvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldildtag
qeeasamrdqymrtgegflcvfainntksfedihqyreqikrvkdsddvpmvlvgnkcdl
aartvesrqaqdlarsygipyietsaktrqgvedafytlvreirqh

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6d59B (B:)
gqmrlpsadvyrfaepdseeniifeenmqpkagipiikagtviklierltyhmyadpnfv
rtflttyrsfckpqellsliierfeipepepteadriaiengdqplsaelkrfrkeyiqp
vqlrvlnvcrhwvehhfydferdayllqrmeefigtvrgkamkkwvesitkiiqrkkiar
dngpghnitfqsspptvewhisrpghietfdlltlhpieiarqltllesdlyravqpsel
vgsvwtkedkeinspnllkmirhttnltlwfekcivetenleervavvsriieilqvfqe
lnnfngvlevvsamnsspvyrldhtfeqipsrqkkileeahelsedhykkylaklrsinp
pcvpffgiyltnilkteegnpevlkrhgkelinfskrrkvaeitgeiqqyqnqpyclrve
sdikrffenlnpmgnsmekeftdylfnksleieprnpkplprfpkkysyplkspgvrpsn
pr

    Sequence, based on observed residues (ATOM records): (download) 
    >6d59B (B:)
gqmrlpsadvyrfaepdseeniifeegipiikagtviklierltyhmyadpnfvrtfltt
yrsfckpqellsliierfeipepepteadriaiengdqplsaelkrfrkeyiqpvqlrvl
nvcrhwvehhfydferdayllqrmeefigtvrgkamkkwvesitkiiqrkkianitfqss
pptvewhisrpghietfdlltlhpieiarqltllesdlyravqpselvgsvwtkedkein
spnllkmirhttnltlwfekcivetenleervavvsriieilqvfqelnnfngvlevvsa
mnsspvyrldhtfeqipsrqkkileeahelsedhykkylaklrsinppcvpffgiyltni
lkteegnpevlkrhgkelinfskrrkvaeitgeiqqyqnqpyclrvesdikrffenlnpm
gnsmekeftdylfnksleieprnpkplprfpkkysyplkspgvrpsnpr

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6d59C (C:)
gmteyklvvvgaggvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldildta
gqeeysamrdqymrtgegflcvfainntksfedihqyreqikrvkdsddvpmvlvgnkcd
laartvesrqaqdlarsygipyietsaktrqgvedafytlvreirqh