PDB entry 6czq

View 6czq on RCSB PDB site
Description: A V-to-F substitution in SK2 channels causes Ca2+ hypersensitivity and improves locomotion in a C. elegans ALS model
Class: metal transport
Keywords: Calcium binding protein, metal transport
Deposited on 2018-04-09, released 2018-08-01
The last revision prior to the SCOPe 2.07 freeze date was dated 2018-08-01, with a file datestamp of 2018-07-27.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: N/A
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'B':
    Compound: Small conductance calcium-activated potassium channel protein 2
    Species: Rattus norvegicus [TaxId:10116]
    Gene: KCNN2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P70604 (0-92)
      • engineered mutation (0)
      • engineered mutation (12)
      • expression tag (93-94)
  • Chain 'R':
    Compound: Calmodulin-1
    Species: Rattus norvegicus [TaxId:10116]
    Gene: Calm1, Calm, Cam, Cam1, CaMI
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0DP29 (2-145)
      • expression tag (0-1)
    Domains in SCOPe 2.07: d6czqr1, d6czqr2
  • Heterogens: SO4, CA, HOH

PDB Chain Sequences:

  • Chain 'B':
    No sequence available.

  • Chain 'R':
    Sequence; same for both SEQRES and ATOM records: (download)
    >6czqR (R:)
    aalteeqiaefkeafslfdkdgdgtittkelgtvmrslgqnpteaelqdminevdadgng
    tidfpefltmmarkmkdtdseeeireafrvfdkdgngyisaaelrhvmtnlgekltdeev
    demireadidgdgqvnyeefvqmmta